Cited by 585Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

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Dendritic spine pathology in schizophrenia

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Glausier, J.R., Lewis, D.A.·2013·Neuroscience

DOI 10.1016/j.neuroscience.2012.04.044PMC PMC3413758

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Abstract

Schizophrenia is a neurodevelopmental disorder whose clinical features include impairments in perception, cognition and motivation. These impairments reflect alterations in neuronal circuitry within and across multiple brain regions that are due, at least in part, to deficits in dendritic spines, the site of most excitatory synaptic connections. Dendritic spine alterations have been identified in multiple brain regions in schizophrenia, but are best characterized in layer 3 of the neocortex, where pyramidal cell spine density is lower. These spine deficits appear to arise during development, and thus are likely the result of disturbances in the molecular mechanisms that underlie spine formation, pruning, and/or maintenance. Each of these mechanisms may provide insight into novel therapeutic targets for preventing or repairing the alterations in neural circuitry that mediate the debilitating symptoms of schizophrenia.

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Systematic characterization of subchronic MK-801 administration across mouse strains identifies conserved synaptic alterations and a clear cognitive phenotype in C57BL/6J mice
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Sparse neuronal C4 elevation induces network-wide transcriptomic and lipid-droplet remodeling in the cortical microenvironment
Sánchez-Carbonell, M., Bolshakova, S., Ávila-Pagán, J. E., Sabir, Y. A., Griffin-Derr, C., Stich, D., Cieslewicz, S. V., Sifuentes, S. E. C., Phadke, R. A., Brack, A., et al. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1014871
Once upon a spine: setting striatal dopamine
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Authors: Glausier, J. R., & Lewis, D. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: Lewis, D.A.
ORCID: Glausier, J.R.
Lewis, D.A.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2013-10
Volume: 251
Pages: 90-107
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2012.04.044
PMC: PMC3413758
OpenAlex: W1997950587
Cited by: 581
References: 248
Citations by year: 2026: 29 · 2025: 37 · 2024: 43 · 2023: 52 · 2022: 50 · 2021: 48 · 2020: 55 · 2019: 42 · 2018: 43 · 2017: 43 · 2016: 42 · 2015: 48 · 2014: 32 · 2013: 12
FWCI: 4.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (P50MH084053, MH084053, R01MH043784, MH043784)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: schizophrenia, dendritic spines, synaptic dysfunction, pyramidal neurons, synaptic pruning, neural circuits, brain development, therapeutic target
MeSH terms: Humans, Schizophrenia, Pyramidal Cells, Neocortex, Dendritic Spines

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Dendritic spine pathology in schizophrenia

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