The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Dendritic spine changes associated with normal aging
Open accessAbstract
Given the rapid rate of population aging and the increased incidence of cognitive decline and neurodegenerative diseases with advanced age, it is important to ascertain the determinants that result in cognitive impairment. It is also important to note that much of the aged population exhibit 'successful' cognitive aging, in which cognitive impairment is minimal. One main goal of normal aging studies is to distinguish the neural changes that occur in unsuccessful (functionally impaired) subjects from those of successful (functionally unimpaired) subjects. In this review, we present some of the structural adaptations that neurons and spines undergo throughout normal aging and discuss their likely contributions to electrophysiological properties and cognition. Structural changes of neurons and dendritic spines during aging, and the functional consequences of such changes, remain poorly understood. Elucidating the structural and functional synaptic age-related changes that lead to cognitive impairment may lead to the development of drug treatments that can restore or protect neural circuits and mediate cognition and successful aging.
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“Development and ageing of the brain are associated with the attrition and loss of neurons1.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [1]
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Epigenetic regulation of brain region-specific microglia clearance activity
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Metadata
- Authors
- Dickstein, D. L., Weaver, C. M., Luebke, J. I., & Hof, P. R.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Franklin & Marshall College (US)
- Boston University (US)
- Corresponding author
- Dickstein, D.L.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 251
- Pages
- 21-32
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3654095
- OpenAlex
- W1983509957
- Cited by
- 289
- References
- 115
- Citations by year
- 2026: 25 · 2025: 22 · 2024: 41 · 2023: 21 · 2022: 25 · 2021: 29 · 2020: 30 · 2019: 14 · 2018: 22 · 2017: 12 · 2016: 19 · 2015: 9 · 2014: 12 · 2013: 8
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG035071, AG025062, R01AG025062, P01AG000001, AG035071, AG00001)
- National Institute of Mental Health (MH071818, R01MH071818)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- dendritic spines, normal aging, successful aging, cognitive aging, cognitive impairment, synaptic plasticity, electrophysiological properties, neurodegenerative diseases
- MeSH terms
- Aging, Animals, Brain, Cognition, Humans, Neuronal Plasticity, Neurons, Dendritic Spines
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