Cited by 289Neuroscience and Neuropharmacology ResearchAging and Gerontology ResearchDementia and Cognitive Impairment Research

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Dendritic spine changes associated with normal aging

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Dickstein, D.L., Weaver, C.M., Luebke, J.I., Hof, P.R.·2013·Neuroscience

DOI 10.1016/j.neuroscience.2012.09.077PMC PMC3654095

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Abstract

Given the rapid rate of population aging and the increased incidence of cognitive decline and neurodegenerative diseases with advanced age, it is important to ascertain the determinants that result in cognitive impairment. It is also important to note that much of the aged population exhibit 'successful' cognitive aging, in which cognitive impairment is minimal. One main goal of normal aging studies is to distinguish the neural changes that occur in unsuccessful (functionally impaired) subjects from those of successful (functionally unimpaired) subjects. In this review, we present some of the structural adaptations that neurons and spines undergo throughout normal aging and discuss their likely contributions to electrophysiological properties and cognition. Structural changes of neurons and dendritic spines during aging, and the functional consequences of such changes, remain poorly understood. Elucidating the structural and functional synaptic age-related changes that lead to cognitive impairment may lead to the development of drug treatments that can restore or protect neural circuits and mediate cognition and successful aging.

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Authors: Dickstein, D. L., Weaver, C. M., Luebke, J. I., & Hof, P. R.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Franklin & Marshall College (US)
Boston University (US)
Corresponding author: Dickstein, D.L.
ORCID: Dickstein, D.L.
Weaver, C.M.
Luebke, J.I.
Hof, P.R.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2013-10
Volume: 251
Pages: 21-32
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2012.09.077
PMC: PMC3654095
OpenAlex: W1983509957
Cited by: 289
References: 115
Citations by year: 2026: 25 · 2025: 22 · 2024: 41 · 2023: 21 · 2022: 25 · 2021: 29 · 2020: 30 · 2019: 14 · 2018: 22 · 2017: 12 · 2016: 19 · 2015: 9 · 2014: 12 · 2013: 8
FWCI: 0.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG035071, AG025062, R01AG025062, P01AG000001, AG035071, AG00001)
National Institute of Mental Health (MH071818, R01MH071818)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: dendritic spines, normal aging, successful aging, cognitive aging, cognitive impairment, synaptic plasticity, electrophysiological properties, neurodegenerative diseases
MeSH terms: Aging, Animals, Brain, Cognition, Humans, Neuronal Plasticity, Neurons, Dendritic Spines

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Dendritic spine changes associated with normal aging

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