The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson s disease
Abstract
Physical exercise is known to produce beneficial effects to the nervous system. In most cases, brain-derived neurotrophic factor (BDNF) is involved in such effects. However, little is known on the role of BDNF in exercise-related effects on Parkinson's disease (PD). The aim of this study was to investigate the effects of intermittent treadmill exercise-induced behavioral and histological/neurochemical changes in a rat model of unilateral PD induced by striatal injection of 6-hydroxydopamine (6-OHDA), and the role of BDNF in the exercise effects. Adult male Wistar rats were divided into two main groups: (1) injection of K252a (a blocker of BDNF receptors), and (2) without BDNF receptor blockade. These groups were then subdivided into four groups: control (CLT), sedentary (SED, non-exercised with induction of PD), exercised 3×/week during four weeks before and four weeks after the induction of PD (EXB+EXA), and exercised 3×/week during four weeks after the induction of PD (EXA). One month after 6-OHDA injections, the animals were subjected to rotational behavioral test induced by apomorphine and the brains were collected for immunohistochemistry and immunoblotting assays, in which we measured BDNF and tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNc) and the striatum (caudate-putamen, CPu). Our results showed a significant reduction of rotational asymmetry induced by apomorphine in the exercised parkinsonian rats. BDNF decreased in the SNc of the SED group, and exercise was able to revert that effect. Exercised groups exhibited reduced damage to the dopaminergic system, detected as a decreased drop of TH levels in SNc and CPu. On the other hand, BDNF blockade was capable of substantially reducing TH expression postlesion, implying enhanced dopaminergic cell loss. Our data revealed that physical exercise is capable of reducing the damage induced by 6-OHDA, and that BDNF receptors are involved in that effect.
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In the citing paper
“BDNF upregulation was observed in midbrain [125], SN [126,128,129], ST [127,129,131,133], hippocampus [133], and cortex [132,133].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [128]
In the citing paper
“Additionally, the use of BDNF receptor inhibitor K252a reversed the protective effect of exercise on rotational bias [128].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [128]
In the citing paper
“Animal studies have shown that long-term endurance training increased both TrkB receptor and TH expression in structures involved in extrapyramidal movement regulation, i.e., in the ST and midbrain [128,129,179,183,184,185].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [128]
In the citing paper
“Animal studies have shown that long-term endurance training increased both TrkB receptor and TH expression in structures involved in extrapyramidal movement regulation, i.e., in the ST and midbrain [128,129,179,183,184,185].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [128]
In the citing paper
“DA depletion in the striatum induces hyper-excitability in the indirect pathway in response to alterations in glutamatergic expression (receptors and neurotransmitter release) and underlies critical aspects of motor impairment in PD 84.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [84]
Citations
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Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739
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Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
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“In models, clinical studies with PD patients have shown that exercise decreases the risk of PD (Chen et al., 2005), improves life quality (Herman et al., 2007), motor coordination (Fisher et al., 2008) and balance (Toole et al., 2000; Goodwin et al., 2008).”
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
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Garcia, P. C. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-12042017-092731
Santos, D. A. A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.47.2018.tde-20122018-101558
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PESQUISAS ENVOLVENDO PACIENTES COM DOENÇA DE PARKINSON NO BRASIL – UMA REVISÃO INTEGRATIVA
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Skelton, H. M., Hyman, N., Fernandez, A. M., Acerbo, E., Scott, M., Berglund, K., Gutekunst, C., & Gross, R. E. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1796624
Meshul, C. K., Moore, C., Shin, K., Sandhu, N. K., Lee, J. S., Zhao, A., & D’Silva, T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29090-9.00017-9
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Metadata
- Authors
- Real, C. C., Ferreira, A. F. B., Chaves-Kirsten, G. P., Torrão, A. S., Pires, R. S., & Britto, L. R. G.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Real, C.C.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 237
- Pages
- 118-129
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2083783300
- Cited by
- 109
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 11 · 2018: 11 · 2017: 12 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 5
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Scopus (Elsevier) (submittedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, brain-derived neurotrophic factor, K252a, treadmill exercise, 6-hydroxydopamine lesion, dopaminergic neuron loss, tyrosine hydroxylase, substantia nigra pars compacta, striatum, apomorphine-induced rotation, neuroprotection
- MeSH terms
- Analysis of Variance, Animals, Apomorphine, Carbazoles, Corpus Striatum, Disease Models, Animal, Enzyme Inhibitors, Exercise Test, Exercise Therapy, Gene Expression Regulation, Male, Parkinson Disease, Putamen, Stereotyped Behavior, Time Factors, Tyrosine 3-Monooxygenase, Oxidopamine, Rats, Wistar, Receptor, trkB, Indole Alkaloids, Rats
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