Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Abstract
We found that a short exercise period enhanced cognitive function on the Morris water maze (MWM), such that exercised animals were significantly better than sedentary controls at learning and recalling the location of the platform. The finding that exercise increased brain-derived neurotrophic factor (BDNF), a molecule important for synaptic plasticity and learning and memory, impelled us to examine whether a BDNF-mediated mechanism subserves the capacity of exercise to improve hippocampal-dependent learning. A specific immunoadhesin chimera (TrkB-IgG), that mimics the BDNF receptor, TrkB, to selectively bind BDNF molecules, was used to block BDNF in the hippocampus during a 1-week voluntary exercise period. After this, a 2-trial-per-day MWM was performed for 5 consecutive days, succeeded by a probe trial 2 days later. By inhibiting BDNF action we blocked the benefit of exercise on cognitive function, such that the learning and recall abilities of exercising animals receiving the BDNF blocker were reduced to sedentary control levels. Inhibiting BDNF action also blocked the effect of exercise on downstream systems regulated by BDNF and important for synaptic plasticity, cAMP response-element-binding protein (CREB) and synapsin I. Specific to exercise, we found an association between CREB and BDNF expression and cognitive function, such that animals who were the fastest learners and had the best recall showed the highest expression of BDNF and associated CREB mRNA levels. These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
When exercise conditions were supplemented with antibodies blocking TrkB, mice had attenuated learning capabilities involving the hippocampus and lacked synaptic-specific proteins in the hippocampus.
“When the exercise conditions were supplemented with antibodies blocking TrkB, however, the mice had attenuated learning capabilities involving the hippocampus. Furthermore, these mice also lacked synaptic-specific proteins in the hippocampus, thereby demonstrating that BDNF signaling is necessary to allow the benefits of exercise to manifest (Vaynman et al., 2004, 2006).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Vaynman et al., 2004
BDNF signaling is necessary to allow the benefits of exercise to manifest.
“When the exercise conditions were supplemented with antibodies blocking TrkB, however, the mice had attenuated learning capabilities involving the hippocampus. Furthermore, these mice also lacked synaptic-specific proteins in the hippocampus, thereby demonstrating that BDNF signaling is necessary to allow the benefits of exercise to manifest (Vaynman et al., 2004, 2006).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Vaynman et al., 2004
BDNF is mechanistically linked to exercise-induced improvement in cognitive functions, such as memory and learning.
“Furthermore, BDNF has been shown to be mechanistically linked to exercise-induced improvement in cognitive functions, such as memory and learning (93, 94).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [93]
Brain-derived neurotrophic factor may be a common pathway mediating exercise-driven brain responses and can drive neuronal plasticity, improve cognition, and protect neurons against insult.
“Neurotrophins, in particular the brain-derived neurotrophic factor, may be the common pathway of these mechanisms, may mediate the exercise-driven brain responses and can drive neuronal plasticity, improve cognition, and protect neurons against insult (60–63).”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [61]
Downregulation of brain-derived neurotrophic factor inhibits aerobic exercise induced improvements in spatial memory performance.
“The importance of BDNF to hippocampal neuroplasticity is epitomized by animal studies, which have found that the manipulation of BDNF expression directly impacts upon performance in spatial and contextual memory tasks (Linnarsson et al., 1997; Alonso et al., 2002; Heldt et al., 2007; Peters et al., 2010), and also that the downregulation of BDNF inhibits AE induced improvements in spatial memory”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Vaynman et al., 2004
Physical activity, cognitive stimulation, and a balanced diet can stimulate BDNF expression in humans and animals.
“Several studies on both humans and animals show that physical activity, cognitive stimulation, and a balanced diet can stimulate BDNF expression [204–207].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [205]
Cites
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180 · see citing works
Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800 · see citing works
Physical activity and risk of cognitive impairment and dementia in elderly persons
Laurin, D., Verreault, R., Lindsay, J., MacPherson, K., & Rockwood, K. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.498 · Cited by 1,561 · see citing works
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462 · see citing works
Molecular cloning and expression of brain-derived neurotrophic factor
Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H., & Barde, Y. (1989) · Nature · doi:10.1038/341149a0 · Cited by 1,458 · see citing works
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works
Ageing, fitness and neurocognitive function
Kramer, A. F., Hahn, S., Cohen, N. J., Banich, M. T., McAuley, E., Harrison, C. R., Chason, J., Vakil, E., Bardell, L., Boileau, R. A., et al. (1999) · Nature · doi:10.1038/22682 · Cited by 1,394 · see citing works
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354 · see citing works
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337 · see citing works
Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function
Greengard, P., Valtorta, F., Czernik, A. J., & Benfenati, F. (1993) · Science · doi:10.1126/science.8430330 · Cited by 1,311 · see citing works
The Trk family of neurotrophin receptors
Barbacid, M. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251107 · Cited by 1,281 · see citing works
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works
Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106 · see citing works
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works
CREB: A Major Mediator of Neuronal Neurotrophin Responses
Finkbeiner, S. M., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80395-5 · Cited by 950 · see citing works
Genetic dissection of consolidated memory in Drosophila
Tully, T., Preat, T., Boynton, S. C., & Del Vecchio, M. (1994) · Cell · doi:10.1016/0092-8674(94)90398-0 · Cited by 924 · see citing works
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
Lohof, A. M., Ip, N. Y., & Poo, M.-M. (1993) · Nature · doi:10.1038/363350a0 · Cited by 755 · see citing works
Dash, P. K., Hochner, B., & Kandel, E. R. (1990) · Nature · doi:10.1038/345718a0 · Cited by 747 · see citing works
Toward a molecular definition of long-term memory storage
Bailey, C. H., Bartsch, D., & Kandel, E. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13445 · Cited by 689 · see citing works
Yin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T. (1995) · Cell · doi:10.1016/0092-8674(95)90375-5 · Cited by 642 · see citing works
Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat.
Sutherland, R., Kolb, B., & Whishaw, I. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90032-5 · Cited by 573 · see citing works
Synapsins as mediators of BDNF-enhanced neurotransmitter release
Jovanovic, J. N., Czernik, A. J., Fienberg, A. A., Greengard, P., & Sihra, T. S. (2000) · Nature Neuroscience · doi:10.1038/73888 · Cited by 566 · see citing works
Mizuno, M., Yamada, K., Olariu, A., Nawa, H., & NABESHIMA, T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-07116.2000 · Cited by 549 · see citing works
Neurotrophin-evoked rapid excitation through TrkB receptors
Kafitz, K. W., Rose, C. R., Thoenen, H., & Konnerth, A. (1999) · Nature · doi:10.1038/44847 · Cited by 542 · see citing works
Synapsins as Regulators of Neurotransmitter Release
Hilfiker, S., Pieribone, V. A., Czernik, A. J., Kao, H.-T., Augustine, G. J., & Greengard, P. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0378 · Cited by 537 · see citing works
Distinct pools of synaptic vesicles in neurotransmitter release
Pieribone, V. A., Shupliakov, O., Brodin, L., Hilfiker, S., Czernik, A. J., & Greengard, P. (1995) · Nature · doi:10.1038/375493a0 · Cited by 532 · see citing works
Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481 · see citing works
CREB Couples Neurotrophin Signals to Survival Messages
Finkbeiner, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)80866-1 · Cited by 454 · see citing works
Rutherford, L. C., Nelson, S. B., & Turrigiano, G. G. (1998) · Neuron · doi:10.1016/s0896-6273(00)80563-2 · Cited by 451 · see citing works
Molteni, R., Ying, Z., & Gómez‐Pinilla, F. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02158.x · Cited by 441 · see citing works
Self-citationCREB and the formation of long-term memory
Yin, J. C. P., & Tully, T. P. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80082-1 · Cited by 399 · see citing works
Shelton, D., Sutherland, J. S., Gripp, J. T., Camerato, T., Armanini, M. P., Phillips, H., Carroll, K., Spencer, S., & Levinson, A. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00477.1995 · Cited by 398 · see citing works
Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.001 · Cited by 396 · see citing works
Self-citationVisualizing synapse formation in arborizing optic axons in vivo: dynamics and modulation by BDNF
Alsina, B., Vu, T., & Cohen‐Cory, S. (2001) · Nature Neuroscience · doi:10.1038/nn735 · Cited by 373 · see citing works
CREB: A mediator of long-term memory from mollusks to mammals
Frank, D. A., & Greenberg, M. E. (1994) · Cell · doi:10.1016/0092-8674(94)90394-8 · Cited by 369 · see citing works
Vicario‐Abejón, C., Collin, C., McKay, R. D. G., & Segal, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07256.1998 · Cited by 368 · see citing works
Improving cognitive function after brain injury: The use of exercise and virtual reality
Grealy, M., Johnson, D. A., & Rushton, S. K. (1999) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(99)90169-7 · Cited by 354 · see citing works
Li, L., Chin, L., Shupliakov, O., Brodin, L., Sihra, T., Hvalby, O., Jensen, V., Zheng, D., McNamara, J. O., & Greengard, P. (1995) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.92.20.9235 · Cited by 351 · see citing works
Molteni, R., Wu, A., Vaynman, S., Ying, Z., Barnard, R. J., & Gómez‐Pinilla, F. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.020 · Cited by 350 · see citing works
Self-citationGENE DISCOVERY INDROSOPHILA: New Insights for Learning and Memory
Dubnau, J., & Tully, T. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.407 · Cited by 336 · see citing works
Neurotrophins: a family of proteins supporting the survival of neurons.
Barde, Y. (1994) · PubMed · Cited by 296 · see citing works
Mu, J.-S., Li, W., Yao, Z., & Zhou, X. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01592-9 · Cited by 282 · see citing works
Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth
Yacoubian, T. A., & Lo, D. C. (2000) · Nature Neuroscience · doi:10.1038/73911 · Cited by 278 · see citing works
Nguyen, P., & Kandel, E. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03189.1996 · Cited by 275 · see citing works
Positive and negative regulatory mechanisms that mediate long-term memory storage
Abel, T. G., & Kandel, E. R. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00050-7 · Cited by 265 · see citing works
Neurotrophic factors and synaptic plasticity
Lo, D. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90085-3 · Cited by 260 · see citing works
Fordyce, D. E., & Wehner, J. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91602-o · Cited by 251 · see citing works
Lom, B., & Cohen‐Cory, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09928.1999 · Cited by 247 · see citing works
Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy
Garcia, C. C., Blair, H. J., Seager, M., Coulthard, A., Tennant, S., Buddles, M., Curtis, A., & Goodship, J. A. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.013680 · Cited by 205 · see citing works
NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation
Riddle, D. R., Lo, D. C., & Katz, L. C. (1995) · Nature · doi:10.1038/378189a0 · Cited by 200 · see citing works
Takei, Y., Harada, A., Takeda, S., Kobayashi, K., Terada, S., Noda, T., Takahashi, T., & Hirokawa, N. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.6.1789 · Cited by 166 · see citing works
Presynaptic depolarization facilitates neurotrophin-induced synaptic potentiation
Boulanger, L. M., & Poo, M.-M. (1999) · Nature Neuroscience · doi:10.1038/7258 · Cited by 159 · see citing works
TrkB Receptor Ligands Promote Activity-Dependent Inhibitory Synaptogenesis
Seil, F. J., & Drake‐Baumann, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05367.2000 · Cited by 144 · see citing works
Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus
Gómez‐Pinilla, F., So, V., & Kesslak, J. P. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02394-0 · Cited by 113 · see citing works
Ando, S., Kobayashi, S., Waki, H., Kon, K., Fukui, F., Tadenuma, T., Iwamoto, M., Takeda, Y., Izumiyama, N., Watanabe, K., et al. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10443 · Cited by 110 · see citing works
Eyre, M. D., Richter‐Levin, G., Avital, A., & Stewart, M. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02624.x · Cited by 103 · see citing works
Mapping Neuronal Inputs to REM Sleep Induction Sites with Carbachol-Fluorescent Microspheres
Quattrochi, J. J., Mamelak, A. N., Madison, R. D., Macklis, J. D., & Hobson, J. A. (1989) · Science · doi:10.1126/science.2475910 · Cited by 94 · see citing works
Shaw, K. N., Commins, S., & O’Mara, S. M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02643.x · Cited by 94 · see citing works
Griesbach, G. S., Hovda, D. A., Molteni, R., & Gómez‐Pinilla, F. (2002) · Journal of Neurotrauma · doi:10.1089/08977150260190401 · Cited by 89 · see citing works
Fluoxetine's Effects on Cognitive Performance in Patients with Traumatic Brain Injury
Horsfield, S. A., Rosse, R. B., Tomasino, V., Schwartz, B. L., Mastropaolo, J. P., & Deutsch, S. I. (2002) · The International Journal of Psychiatry in Medicine · doi:10.2190/kq48-xt0l-2h14-5umv · Cited by 87 · see citing works
Tsai, S., Hong, C., Liu, H.-C., Liu, T., Hsu, L.-E., & Lin, C. (2004) · Neuropsychobiology · doi:10.1159/000075332 · Cited by 79 · see citing works
Melloni, R. H., Apostolides, P. J., Hamos, J. E., & DeGennaro, L. J. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90448-0 · Cited by 66 · see citing works
Blanquet, P., & Lamour, Y. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24133 · Cited by 63 · see citing works
Co-infusion with a TrkB-Fc Receptor Body Carrier Enhances BDNF Distribution in the Adult Rat Brain
Croll, S. D., Chesnutt, C. R., Rudge, J. S., Acheson, A. L., RYAN, T. E., Siuciak, J. A., DiStefano, P. S., Wiegand, S. J., & Lindsay, R. M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6836 · Cited by 63 · see citing works
Egan, M. F., Weinberger, D. R., & Lu, B. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1242 · Cited by 61 · see citing works
Focal Delivery of Neurotrophins into the Central Nervous System Using Fluorescent Latex Microspheres
Riddle, D. R., Katz, L. C., & Lo, D. C. (1997) · BioTechniques · doi:10.2144/97235rr02 · Cited by 38 · see citing works
MEEUSEN, R. R. (2003) · VUBIR (Vrije Universiteit Brussel) · Cited by 28 · see citing works
Localization of synapsin I in normal fibers and regenerating axonal sprouts of the rat sciatic nerve
赤木, 秀., Mizoguchi, A., Sobue, K., Nakamura, H., & Idé, C. (1996) · Histochemistry and Cell Biology · doi:10.1007/bf01463657 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Smith, P. J., Blumenthal, J. A., Hoffman, B. M., Cooper, H., Strauman, T. A., Welsh-Bohmer, K., Browndyke, J. N., & Sherwood, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d14633 · Cited by 1,714 · see citing works
Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495 · see citing works
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359 · see citing works
Brain foods: The effects of nutrients on brain function.
Gómez-Pinilla, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2421 · Cited by 1,372 · see citing works
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226 · see citing works
“Furthermore, BDNF has been shown to be mechanistically linked to exerciseinduced improvement in cognitive functions, such as memory and learning (93, 94).”
BackgroundEffects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial
Baker, L. D., Frank, L. L., Foster-Schubert, K., Green, P. S., Wilkinson, C. W., McTiernan, A., Plymate, S. R., Fishel, M. A., Watson, G. S., Cholerton, B. A., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.307 · Cited by 1,171 · see citing works
“on memory have been reported in a few clinical trials,(20,21) although most support for a memory benefit comes from animal research.(8,11,22,23) In humans, results of crosssectional(24) and prospective(25) brain imaging studies suggest that increased aerobic fitness in cognitively healthy older adults is associated wi…”
Mandolesi, L., Polverino, A., Montuori, S., Foti, F., Ferraioli, G., Sorrentino, P., & Sorrentino, G. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00509 · Cited by 1,038 · see citing works
Beneficial effects of physical exercise on neuroplasticity and cognition
Hötting, K., & Röder, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.005 · Cited by 991 · see citing works
Aerobic fitness is associated with hippocampal volume in elderly humans
Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Hu, L., Morris, K. S., White, S. M., Wójcicki, T. R., McAuley, E., & Kramer, A. F. (2009) · Hippocampus · doi:10.1002/hipo.20547 · Cited by 1,007 · see citing works
Dishman, R. K., Berthoud, H., Booth, F. W., Cotman, C. W., Edgerton, V. R., Fleshner, M. R., Gandevia, S. C., Gomez‐Pinilla, F., Greenwood, B. N., Hillman, C. H., et al. (2006) · Obesity · doi:10.1038/oby.2006.46 · Cited by 958 · see citing works
Self-citationBasso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911 · see citing works
A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor
Szuhany, K. L., Bugatti, M., & Otto, M. W. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.10.003 · Cited by 909 · see citing works
Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882 · see citing works
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R., & Petersen, R. C. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0252 · Cited by 885 · see citing works
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works
FERRIS, L. T., WILLIAMS, J. S., & SHEN, C.-L. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04c7 · Cited by 849 · see citing works
Exercise is the real polypill.
Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A. (2013) · Physiology · doi:10.1152/physiol.00019.2013 · Cited by 791 · see citing works
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772 · see citing works
Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function
Kramer, A. F., & Erickson, K. I. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.06.009 · Cited by 741 · see citing works
A meta-regression to examine the relationship between aerobic fitness and cognitive performance
Etnier, J. L., Nowell, P. M., Landers, D. M., & Sibley, B. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.01.002 · Cited by 749 · see citing works
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Chaddock, L., Erickson, K. I., Prakash, R. S., Kim, J. S., Voss, M. W., VanPatter, M., Pontifex, M. B., Raine, L. B., Konkel, A., Hillman, C. H., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.049 · Cited by 687 · see citing works
Neurogenesis and Exercise: Past and Future Directions
van Praag, H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8028-z · Cited by 645 · see citing works
Systemic adaptation to oxidative challenge induced by regular exercise
Radak, Z., Chung, H. Y., & Goto, S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.029 · Cited by 623 · see citing works
Exercise, brain, and cognition across the life span.
Voss, M. W., Nagamatsu, L. S., Liu-Ambrose, T., & Kramer, A. F. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00210.2011 · Cited by 601 · see citing works
Kapogiannis, D., & Mattson, M. P. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70277-5 · Cited by 594 · see citing works
BDNF mediates adaptive brain and body responses to energetic challenges
Marosi, K., & Mattson, M. P. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.10.006 · Cited by 568 · see citing works
Ding, Q., Vaynman, S., Akhavan, M., Ying, Z., & Gomez-Pinilla, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.084 · Cited by 555 · see citing works
Self-citationExercise-Mediated Neurogenesis in the Hippocampus via BDNF
Liu, P. Z., & Nusslock, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00052 · Cited by 533 · see citing works
Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis
Firth, J., Stubbs, B., Vancampfort, D., Schuch, F., Lagopoulos, J., Rosenbaum, S., & Ward, P. B. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.007 · Cited by 526 · see citing works
Firth, J., Stubbs, B., Rosenbaum, S., Vancampfort, D., Malchow, B., Schuch, F., Elliott, R., Nuechterlein, K. H., & Yung, A. R. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw115 · Cited by 488 · see citing works
Huang, T., Larsen, K. T., Ried‐Larsen, M., Møller, N. C., & Andersen, L. B. (2014) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12069 · Cited by 485 · see citing works
The effects of cardiovascular exercise on human memory: a review with meta-analysis
Roig, M., Nordbrandt, S., Geertsen, S. S., & Nielsen, J. B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.012 · Cited by 460 · see citing works
Vaynman, S., & Gomez-Pinilla, F. (2005) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968305280753 · Cited by 420 · see citing works
Self-citationExercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413 · see citing works
Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms
Cassilhas, R. C., Lee, K. S., Fernandes, J., Oliveira, M. G. M., Tufik, S., Meeusen, R., & de Mello, M. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.029 · Cited by 394 · see citing works
Cardiovascular fitness is associated with cognition in young adulthood
Åberg, M. A. I., Pedersen, N. L., Torén, K., Svartengren, M., Bäckstrand, B., Johnsson, T., Cooper-Kuhn, C. M., Åberg, N. D., Nilsson, M., & Kuhn, H. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905307106 · Cited by 382 · see citing works
Physical Activity and Cognitive Vitality
Prakash, R. S., Voss, M. W., Erickson, K. I., & Kramer, A. F. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015249 · Cited by 376 · see citing works
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis
Vivar, C., Potter, M. C., & van Praag, H. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_220 · Cited by 370 · see citing works
Chaddock, L., Pontifex, M. B., Hillman, C. H., & Kramer, A. F. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711000567 · Cited by 369 · see citing works
Gomez‐Pinilla, F., Zhuang, Y., Feng, J., Ying, Z., & Fan, G. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07508.x · Cited by 367 · see citing works
Basal Ganglia Volume Is Associated with Aerobic Fitness in Preadolescent Children
Chaddock, L., Erickson, K. I., Prakash, R. S., VanPatter, M., Voss, M. W., Pontifex, M. B., Raine, L. B., Hillman, C. H., & Kramer, A. F. (2010) · Developmental Neuroscience · doi:10.1159/000316648 · Cited by 353 · see citing works
Rojas Vega, S., Strüder, H. K., Vera Wahrmann, B., Schmidt, A., Bloch, W., & Hollmann, W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.105 · Cited by 357 · see citing works
Physical exercise, neuroplasticity, spatial learning and memory
Cassilhas, R. C., Tufik, S., & de Mello, M. T. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2102-0 · Cited by 340 · see citing works
Middleton, L. E., Barnes, D. E., Lui, L., & Yaffe, K. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02903.x · Cited by 339 · see citing works
Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
Sallam, N., & Laher, I. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7239639 · Cited by 334 · see citing works
Running induces widespread structural alterations in the hippocampus and entorhinal cortex
Stranahan, A. M., Khalil, D., & Gould, E. (2007) · Hippocampus · doi:10.1002/hipo.20348 · Cited by 327 · see citing works
Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling
Phillips, C., Baktir, M. A., Srivatsan, M., & Salehi, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00170 · Cited by 330 · see citing works
Marlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22009 · Cited by 314 · see citing works
Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives
Rolland, Y., Abellan van Kan, G., & Vellas, B. (2008) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2008.02.007 · Cited by 312 · see citing works
BDNF mediates improvements in executive function following a 1-year exercise intervention.
Leckie, R. L., Oberlin, L. E., Voss, M. W., Prakash, R. S., Szabo-Reed, A., Chaddock-Heyman, L., Phillips, S. M., Gothe, N. P., Mailey, E., Vieira-Potter, V. J., et al. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00985 · Cited by 307 · see citing works
Vaynman, S., & Gomez‐Pinilla, F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20979 · Cited by 299 · see citing works
Self-citationZucchella, C., Sinforiani, E., Tamburin, S., Federico, A., Mantovani, E., Bernini, S., Casale, R., & Bartolo, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01058 · Cited by 297 · see citing works
Mortimer, J. A., Ding, D., Borenstein, A. R., DeCarli, C., Guo, Q., Wu, Y., Zhao, Q., & Chu, S. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-120079 · Cited by 281 · see citing works
BDNF induction with mild exercise in the rat hippocampus
Soya, H., Nakamura, T., Deocaris, C. C., Kimpara, A., Iimura, M., Fujikawa, T., Chang, H., McEwen, B. S., & Nishijima, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.173 · Cited by 269 · see citing works
Pang, T. Y. C., Stam, N. C., Nithianantharajah, J., Howard, M. L., & Hannan, A. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.013 · Cited by 265 · see citing works
Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity.
Edelmann, E., Leßmann, V., & Brigadski, T. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.043 · Cited by 248 · see citing works
Positive effects of acute and moderate physical exercise on cognitive function
Kashihara, K., Maruyama, T., Murota, M., & Nakahara, Y. (2009) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.2114/jpa2.28.155 · Cited by 238 · see citing works
Central Mechanisms of HPA Axis Regulation by Voluntary Exercise
Stranahan, A. M., Lee, K., & Mattson, M. P. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8027-0 · Cited by 235 · see citing works
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241 · see citing works
Exercise and Hippocampal Memory Systems
Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.006 · Cited by 235 · see citing works
Aerobic endurance exercise benefits memory and affect in young adults.
Stroth, S., Hille, K., Spitzer, M., & Reinhardt, R. (2009) · Neuropsychological Rehabilitation · doi:10.1080/09602010802091183 · Cited by 232 · see citing works
Is Alzheimer’s disease a systemic disease?
Morris, J. K., Honea, R. A., Vidoni, E. D., Swerdlow, R. H., & Burns, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.012 · Cited by 219 · see citing works
Liu, Y., Chen, H., Wu, C., Kuo, Y., Yu, L., Huang, A., Wu, F., Chuang, J., & Jen, C. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173088 · Cited by 199 · see citing works
Intlekofer, K. A., Berchtold, N. C., Malvaez, M., Carlos, A. J., McQuown, S. C., Cunningham, M. J., Wood, M. A., & Cotman, C. W. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.104 · Cited by 190 · see citing works
Ploughman, M., Granter-Button, S., Chernenko, G., Attwood, Z., Tucker, B. A., Mearow, K. M., & Corbett, D. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.065 · Cited by 170 · see citing works
Voss, M. W., Carr, L. J., Clark, R., & Weng, T. (2014) · Mental health and physical activity · doi:10.1016/j.mhpa.2014.01.001 · Cited by 164 · see citing works
Myokines mediate the cross talk between skeletal muscle and other organs
Chen, W., Wang, L., You, W., & Shan, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30033 · Cited by 162 · see citing works
Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor
Huang, A. M., Jen, C. J., Chen, H. F., Yu, L., Kuo, Y. M., & Chen, H. I. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-005-0359-4 · Cited by 155 · see citing works
Exercise programs for people with dementia
Forbes, D., Thiessen, E. J., Blake, C. M., Forbes, S. C., & Forbes, S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006489.pub3 · Cited by 154 · see citing works
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“…directly impacts upon performance in spatial and contextual memory tasks (Linnarsson et al., 1997; Alonso et al., 2002; Heldt et al., 2007; Peters et al., 2010), and also that the downregulation of BDNF inhibits AE induced improvements in spatial memory performance (Vaynman et al., 2004).”
Uysal, N., Kiray, M., Sisman, A., Camsari, U., Gencoglu, C., Baykara, B., Cetinkaya, C., & Aksu, I. (2015) · Biotechnic & Histochemistry · doi:10.3109/10520295.2014.946968 · Cited by 154 · see citing works
The effects of physical exercise and cognitive training on memory and neurotrophic factors.
Heisz, J. J., Clark, I. B., Bonin, K., Paolucci, E. M., Michalski, B., Becker, S., & Fahnestock, M. (2017) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01164 · Cited by 144 · see citing works
O'Callaghan, R. M., Griffin, É. W., & Kelly, Á. M. (2009) · Hippocampus · doi:10.1002/hipo.20591 · Cited by 146 · see citing works
Barrientos, R. M., Frank, M. G., Crysdale, N. Y., Chapman, T. R., Ahrendsen, J. T., Day, H. E. W., Campeau, S., Watkins, L. R., Patterson, S. L., & Maier, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2266-11.2011 · Cited by 148 · see citing works
So, N., Franks, B., Lim, S., & Curley, J. P. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134509 · Cited by 135 · see citing works
Joggin’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits
Stimpson, N. J., Davison, G., & Javadi, A.-H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.018 · Cited by 134 · see citing works
Hwang, J., Brothers, R. M., Castelli, D. M., Glowacki, E. M., Chen, Y. T., Salinas, M. M., Kim, J., Jung, Y., & Calvert, H. G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.07.033 · Cited by 126 · see citing works
Salzman, T., Sarquis-Adamson, Y., Son, S., Montero-Odasso, M., & Fraser, S. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.6744 · Cited by 125 · see citing works
Li, J. W., O’Connor, H., O’Dwyer, N., & Orr, R. (2017) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2016.11.025 · Cited by 125 · see citing works
Krogh, J., Rostrup, E., Thomsen, C., Elfving, B., Videbech, P., & Nordentoft, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.041 · Cited by 123 · see citing works
Mackay, C. P., Kuys, S. S., & Brauer, S. G. (2017) · Neural Plasticity · doi:10.1155/2017/4716197 · Cited by 125 · see citing works
A brief primer on the mediational role of <scp>BDNF</scp> in the exercise‐memory link
Loprinzi, P. D., & Frith, E. (2019) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12522 · Cited by 116 · see citing works
Real, C. C., Ferreira, A. F. B., Chaves-Kirsten, G. P., Torrão, A. S., Pires, R. S., & Britto, L. R. G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.060 · Cited by 109 · see citing works
Cardiorespiratory Fitness and Accelerated Cognitive Decline With Aging
Wendell, C. R., Gunstad, J., Waldstein, S. R., Wright, J. G., Ferrucci, L., & Zonderman, A. B. (2014) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glt144 · Cited by 104 · see citing works
Physical activity moderates effects of stressor-induced rumination on cortisol reactivity
Puterman, E., O'Donovan, A., Adler, N. E., Tomiyama, A. J., Kemeny, M., Wolkowitz, O. M., & Epel, E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318229e1e0 · Cited by 106 · see citing works
Healthy Brain Aging: Role of Exercise and Physical Activity
Rolland, Y., Abellan van Kan, G., & Vellas, B. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.11.002 · Cited by 103 · see citing works
Angiogenesis but not neurogenesis is critical for normal learning and memory acquisition.
Kerr, A. L., Steuer, E. L., Pochtarev, V., & Swain, R. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.008 · Cited by 103 · see citing works
Liu, Y.-F., Chen, H.-I., Yu, L., Kuo, Y.-M., Wu, F.-S., Chuang, J.-I., Liao, P.-C., & Jen, C. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.02.005 · Cited by 98 · see citing works
Fahimi, A., Baktir, M. A., Moghadam, S., Mojabi, F. S., Sumanth, K., McNerney, M. W., Ponnusamy, R., & Salehi, A. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1308-8 · Cited by 94 · see citing works
Neuroprotective Effects of Exercise Treatments after Injury: The Dual Role of Neurotrophic Factors
Cobianchi, S., Arbat-Plana, A., Lopez-Alvarez, V. M., & Navarro, X. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160330105132 · Cited by 94 · see citing works
Le Grevès, M., Zhou, Q., Berg, M., Le Grevès, P., Fhölenhag, K., Meyerson, B., & Nyberg, F. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0438-2 · Cited by 92 · see citing works
exercise influence on hippocampal function: possible involvement of orexin-A
Chieffi, S., Messina, G., Villano, I., Messina, A., Esposito, M., Monda, V., Valenzano, A., Moscatelli, F., Esposito, T., Carotenuto, M., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00085 · Cited by 90 · see citing works
Shafia, S., Vafaei, A. A., Samaei, S. A., Bandegi, A. R., Rafiei, A., Valadan, R., Hosseini-Khah, Z., Mohammadkhani, R., & Rashidy-Pour, A. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.01.009 · Cited by 89 · see citing works
- Authors
- Vaynman, S., Ying, Z., & Gomez‐Pinilla, F.
- Affiliations
- University of California, Los Angeles (US)
- ORCID
- Ying, Zhe
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2004-11
- Volume
- 20
- Issue
- 10
- Pages
- 2580-2590
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2119757776
- Cited by
- 1,460
- References
- 70
- Citations by year
- 2026: 49 · 2025: 63 · 2024: 59 · 2023: 62 · 2022: 69 · 2021: 90 · 2020: 75 · 2019: 90 · 2018: 69 · 2017: 107 · 2016: 90 · 2015: 88 · 2014: 93 · 2013: 96 · 2012: 65
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS 39522, R01NS045804, NS 045804, R01NS039522)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- physical activity, brain-derived neurotrophic factor, hippocampus, synaptic plasticity, learning and memory, TrkB receptor, CREB, synapsin I, voluntary exercise, Morris water maze, cognitive function
- MeSH terms
- Animals, Behavior, Animal, Cognition, DNA-Binding Proteins, Gene Expression Regulation, Hippocampus, Humans, Immunoglobulin G, Male, Memory, Microspheres, Models, Biological, Motor Activity, Neuronal Plasticity, Physical Conditioning, Animal, Reaction Time, RNA, Messenger, Spatial Behavior, Time Factors, Transcription Factors, Blotting, Western, Synapsins, Rats, Sprague-Dawley, Maze Learning, Brain-Derived Neurotrophic Factor, Reverse Transcriptase Polymerase Chain Reaction, Receptor, trkB, Rats, Activating Transcription Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
