Increased expression of BDNF transcript with exon VI in hippocampi of patients with pharmaco-resistant temporal lobe epilepsy
Abstract
A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples. We assessed the BDNF expression of transcripts with exons I (BDNFI), II (BDNFII), IV (BDNFIV) and VI (BDNFVI) and methylation levels of promoters 4 and 6 in the hippocampi of patients with pharmaco-resistant temporal lobe epilepsy (TLE) (n=24). Hippocampal sclerosis (HS) and pre-surgical pharmacological treatment were considered as clinical independent variables. A statistical significant increase for the BDNFVI (p<0.05) was observed in TLE patients compared to the autopsy control group (n=8). BDNFVI was also increased in anxiety/depression TLE (N=4) when compared to autopsies or to the remaining group of patients (p<0.05). In contrast, the use of the antiepileptic drug Topiramate (TPM) (N=3) was associated to a decrease in BDNFVI expression (p<0.05) when compared to the remaining group of patients. Methylation levels at the BDNF promoters 4 and 6 were similar between TLE and autopsies and in relation to the use of either Sertraline (SRT) or TPM. These results suggest an up-regulated expression of a specific BDNF transcript in patients with TLE, an effect that seems to be dependent on the use of specific drugs.
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BDNF gene expression is increased in the hippocampus and temporal cortex of temporal lobe epilepsy patients.
“Two recent reports have shown that BDNF gene expression is increased in the hippocampus and temporal cortex of temporal lobe epilepsy patients [179, 180].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [180]
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- Authors
- Martínez-Levy, G. A., Rocha, L., Lubin, F. D., Alonso-Vanegas, M. A., Nani, A., Buentello-García, R. M., Pérez-Molina, R., Briones-Velasco, M., Recillas-Targa, F., Pérez-Molina, A., San-Juan, D., Cienfuegos, J., & Cruz-Fuentes, C. S.
- Affiliations
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
- University of Alabama at Birmingham (US)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Corresponding author
- Cruz-Fuentes, C.S.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 314
- Pages
- 12-21
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2175445854
- Cited by
- 33
- References
- 52
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 4 · 2018: 4 · 2017: 2 · 2016: 2
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Psychiatry
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- brain-derived neurotrophic factor, BDNF isoforms, hippocampus, hippocampal sclerosis, promoter methylation, topiramate, sertraline, antiepileptic drugs, gene expression
- MeSH terms
- Topiramate, Adult, Aged, Anticonvulsants, Epilepsy, Temporal Lobe, Exons, Female, Fructose, Hippocampus, Humans, Male, Middle Aged, Promoter Regions, Genetic, RNA, Messenger, DNA Methylation, Brain-Derived Neurotrophic Factor, Sertraline, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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