Increased Expression of Brain-Derived Neurotrophic Factor Transcripts I and VI, cAMP Response Element Binding, and Glucocorticoid Receptor in the Cortex of Patients with Temporal Lobe Epilepsy
Abstract
A body of evidence supports a relevant role of brain-derived neurotrophic factor (BDNF) in temporal lobe epilepsy (TLE). Magnetic resonance data reveal that the cerebral atrophy extends to regions that are functionally and anatomically connected with the hippocampus, especially the temporal cortex. We previously reported an increased expression of BDNF messenger for the exon VI in the hippocampus of temporal lobe epilepsy patients compared to an autopsy control group. Altered levels of this particular transcript were also associated with pre-surgical use of certain psychotropic. We extended here our analysis of transcripts I, II, IV, and VI to the temporal cortex since this cerebral region holds intrinsic communication with the hippocampus and is structurally affected in patients with TLE. We also assayed the cyclic adenosine monophosphate response element-binding (CREB) and glucocorticoid receptor (GR) genes as there is experimental evidence of changes in their expression associated with BDNF and epilepsy. TLE and pre-surgical pharmacological treatment were considered as the primary clinical independent variables. Transcripts BDNF I and BDNF VI increased in the temporal cortex of patients with pharmacoresistant TLE. The expression of CREB and GR expression follow the same direction. Pre-surgical use of selective serotonin reuptake inhibitors, carbamazepine (CBZ) and valproate (VPA), was associated with the differential expression of specific BDNF transcripts and CREB and GR genes. These changes could have functional implication in the plasticity mechanisms related to temporal lobe epilepsy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BDNF gene expression is increased in the hippocampus and temporal cortex of temporal lobe epilepsy patients.
“Two recent reports have shown that BDNF gene expression is increased in the hippocampus and temporal cortex of temporal lobe epilepsy patients [179, 180].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [179]
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Analyzing real-time PCR data by the comparative CT method
Schmittgen, T. D., & Livak, K. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.73 · Cited by 26,190 · see citing works
Mouse and rat <i>BDNF</i> gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works
A validation study of the hospital anxiety and depression scale (HADS) in a Spanish population
Herrero, M. J., Blanch, J., Peri, J. M., De Pablo, J., Pintor, L., & Bulbena, A. (2003) · General Hospital Psychiatry · doi:10.1016/s0163-8343(03)00043-4 · Cited by 892 · see citing works
Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007) · Genomics · doi:10.1016/j.ygeno.2007.05.004 · Cited by 699 · see citing works
Ernfors, P., Bengzon, J., Kokaia, Z., Persson, H., & Lindvall, O. (1991) · Neuron · doi:10.1016/0896-6273(91)90084-d · Cited by 628 · see citing works
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
Anacker, C., Zunszain, P. A., Carvalho, L. A., & Pariante, C. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.007 · Cited by 592 · see citing works
Ridder, S., Chourbaji, S., Hellweg, R., Urani, A., Zacher, C., Schmid, W., Zink, M., Hörtnagl, H., Flor, H., Henn, F. A., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0736-05.2005 · Cited by 382 · see citing works
Yasuda, S., Liang, M.-H., Marinova, Z., Yahyavi, A., & Chuang, D.-M. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002099 · Cited by 358 · see citing works
Chen, P.-S., Peng, G.-S., Li, G., Yang, S., Wu, X., Wang, C. C., Wilson, B. C., Lu, R.-B., Gean, P.-W., Chuang, D.-M., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001893 · Cited by 352 · see citing works
Croll, S. D., Suri, C., Compton, D. L., Simmons, M. V., Yancopoulos, G. D., Lindsay, R. M., Wiegand, S. J., Rudge, J., & Scharfman, H. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00296-1 · Cited by 310 · see citing works
Which seizure-precipitating factors do patients with epilepsy most frequently report?
Nakken, K. O., Solaas, M. H., Kjeldsen, M. J., Friis, M. L., Pellock, J. M., & Corey, L. A. (2004) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2004.11.003 · Cited by 277 · see citing works
Suri, D., & Vaidya, V. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.065 · Cited by 253 · see citing works
Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment.
Goldenberg, M. M. (2010) · PubMed · Cited by 237 · see citing works
Pruunsild, P., Sepp, M., Orav, E., Koppel, I., & Timmusk, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4540-10.2011 · Cited by 230 · see citing works
Liu, G., Gu, B., He, X.-P., Joshi, R. B., Wackerle, H. D., Rodriguiz, R. M., Wetsel, W. C., & McNamara, J. O. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.027 · Cited by 210 · see citing works
Fukuchi, M., Nii, T., Ishimaru, N., Minamino, A., Hara, D., Takasaki, I., Tabuchi, A., & Tsuda, M. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.05.002 · Cited by 202 · see citing works
Baj, G., Leone, E., Chao, M. V., & Tongiorgi, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014168108 · Cited by 196 · see citing works
BDNF‐mediated signal transduction is modulated by GSK3β and mood stabilizing agents
Mai, L., Jope, R. S., & Li, X. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00939.x · Cited by 195 · see citing works
Do epileptic seizures damage the brain?
Sutula, T. P., Hagen, J., & Pitkänen, A. (2003) · Current Opinion in Neurology · doi:10.1097/01.wco.0000063770.15877.bc · Cited by 195 · see citing works
Do epileptic seizures damage the brain?
Sutula, T. P., Hagen, J., & Pitkänen, A. (2003) · Current Opinion in Neurology · doi:10.1097/00019052-200304000-00012 · Cited by 193 · see citing works
Blümcke, I., Coras, R., Miyata, H., & Özkara, Ç. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00583.x · Cited by 190 · see citing works
Bonilha, L., Rorden, C., Castellano, G., Pereira, F., Rio, P. A., Cendes, F., & Li, L. M. (2004) · Archives of Neurology · doi:10.1001/archneur.61.9.1379 · Cited by 187 · see citing works
Numakawa, T., Adachi, N., Richards, M., Chiba, S., & Kunugi, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.073 · Cited by 180 · see citing works
Network atrophy in temporal lobe epilepsy
Riederer, F., Lanzenberger, R. R., Kaya, M., Prayer, D., Serles, W., & Baumgartner, C. (2008) · Neurology · doi:10.1212/01.wnl.0000324264.96100.e0 · Cited by 160 · see citing works
BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae
Chiaruttini, C., Sonego, M., Baj, G., Simonato, M., & Tongiorgi, E. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.08.011 · Cited by 156 · see citing works
Paradiso, B., Marconi, P., Zucchini, S., Berto, E., Binaschi, A., Bozac, A., Buzzi, A., Mazzuferi, M., Magri, E., Mora, G. N., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810710106 · Cited by 155 · see citing works
Mueller, S. G., Laxer, K. D., Cashdollar, N. M., Buckley, S. T., Paul, C., & Weiner, M. W. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00512.x · Cited by 150 · see citing works
Sperling, M. R., Schilling, C. A., Glosser, D. S., Tracy, J. I., & Asadi‐Pooya, A. A. (2007) · Seizure · doi:10.1016/j.seizure.2007.09.003 · Cited by 148 · see citing works
Moore, A. N., Waxham, M. N., & Dash, P. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14214 · Cited by 144 · see citing works
Are BDNF and glucocorticoid activities calibrated?
Jeanneteau, F. D., & Chao, M. V. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.017 · Cited by 141 · see citing works
Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells
Chen, H., Lombès, M., & Le Menuet, D. (2017) · Molecular Brain · doi:10.1186/s13041-017-0295-x · Cited by 138 · see citing works
Humpel, C., Wetmore, C., & Olson, L. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90476-v · Cited by 133 · see citing works
Takahashi, M., Hayashi, S., Kakita, A., Wakabayashi, K., Fukuda, M., Kameyama, S., Tanaka, R., Takahashi, H., & Nawa, H. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01355-9 · Cited by 132 · see citing works
Tassi, L., Meroni, A., Deleo, F., et al. (2009) · Epileptic Disorders · doi:10.1684/epd.2009.0279 · Cited by 124 · see citing works
Lambert, W. M., Xu, C., Neubert, T. A., Chao, M. V., Garabedian, M. J., & Jeanneteau, F. D. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00150-13 · Cited by 116 · see citing works
Varela, R. B., Valvassori, S. S., Lopes-Borges, J., Mariot, E., Dal-Pont, G. C., Amboni, R. T., Bianchini, G., & Quevedo, J. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.11.003 · Cited by 115 · see citing works
Medial temporal lobe atrophy in patients with refractory temporal lobe epilepsy
Bonilha, L. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.12.1627 · Cited by 105 · see citing works
Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area
Koo, J. W., Mazei‐Robison, M. S., LaPlant, Q. C., Egervári, G., Braunscheidel, K. M., Adank, D. N., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3932 · Cited by 104 · see citing works
Layer-Specific CREB Target Gene Induction in Human Neocortical Epilepsy
Beaumont, T., Yao, B. W., Shah, A. K., Kapatos, G., & Loeb, J. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3408-12.2012 · Cited by 103 · see citing works
Baj, G., D'Alessandro, V., Musazzi, L., Mallei, A., Sartori, C. R., Sciancalepore, M., Tardito, D., Langone, F., Popoli, M., & Tongiorgi, E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.5 · Cited by 103 · cited 3× · see citing works
“In a similar way, BDNF VI variant increase in the apical dendrites of CA3 neurons in mice exposed to an antidepressive treatment or voluntary exercise [58], a re-”
BackgroundInfluentialFauser, S., & Schulze‐Bonhage, A. (2005) · Brain · doi:10.1093/brain/awh687 · Cited by 103 · see citing works
Vezzani, A., Ravizza, T., Moneta, D., Conti, M., Borroni, A., Rizzi, M., SAMANIN, R., & Maj, R. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00553-3 · Cited by 101 · see citing works
Xu, B., Michalski, B., Racine, R. J., & Fahnestock, M. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.044 · Cited by 100 · see citing works
Mathern, G. W., Babb, T. L., Micevych, P. E., Blanco, C. E., & Pretorius, J. K. (1997) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815150 · Cited by 99 · see citing works
Angels and demons: neurotrophic factors and epilepsy
Simonato, M., Tongiorgi, E., & Kokaia, M. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.10.002 · Cited by 96 · see citing works
Increased BDNF expression in fetal brain in the valproic acid model of autism
Almeida, L. E. F., Roby, C. D., & Krueger, B. K. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.01.007 · Cited by 95 · see citing works
Lambert, W. M., Xu, C., Neubert, T. A., Chao, M. V., Garabedian, M. J., & Jeanneteau, F. D. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01139-13 · Cited by 93 · see citing works
Shen, H.-Y., Kalda, A., Yu, L., Ferrara, J., Zhu, J., & Chen, J.-F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.019 · Cited by 91 · see citing works
A common pattern of persistent gene activation in human neocortical epileptic foci
Rakhade, S. N., Yao, B. W., Ahmed, S. F., Asano, E., Beaumont, T., Shah, A. K., Drăghici, S., Krauss, R., Chugani, H. T., Sood, S., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20633 · Cited by 91 · see citing works
Decreased CREB levels suppress epilepsy
Zhu, X., Han, X., Blendy, J. A., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.08.009 · Cited by 90 · see citing works
Chang, Y. C., Rapoport, S. I., & Rao, J. S. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9817-3 · Cited by 86 · see citing works
Page, L. R., & Parries, S. C. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000320)418:4 · Cited by 85 · see citing works
Galimberti, C. A., Magri, F., Copello, F., Arbasino, C., Cravello, L., Casu, M., Patrone, V., & Murialdo, G. (2005) · Epilepsia · doi:10.1111/j.0013-9580.2005.59704.x · Cited by 78 · see citing works
Paradiso, B., Zucchini, S., Su, T., Bovolenta, R., Berto, E., Marconi, P., Marzola, A., Mora, G. N., Fabene, P. F., & Simonato, M. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2010.02930.x · Cited by 73 · see citing works
CREB Binding and Activity in Brain: Regional Specificity and Induction by Electroconvulsive Seizure
Tanis, K. Q., Duman, R. S., & Newton, S. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.003 · Cited by 68 · see citing works
Usui, T., Saitoh, Y., & Komada, F. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.510 · Cited by 64 · see citing works
Gómez-Arias, B., Crail‐Meléndez, D., Zapata, R. L., & Martínez-Juárez, I. E. (2012) · Seizure · doi:10.1016/j.seizure.2012.06.003 · Cited by 63 · see citing works
Long, Z., Zhao, L., Jiang, R., Wang, K., Luo, S., Zheng, M., Li, X., & He, G. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12445 · Cited by 62 · see citing works
Schulte‐Herbrüggen, O., Chourbaji, S., Ridder, S., Brandwein, C., Gass, P., Hörtnagl, H., & Hellweg, R. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.09.008 · Cited by 60 · see citing works
Tongiorgi, E., Domenici, L., & Simonato, M. (2005) · Molecular Neurobiology · doi:10.1385/mn:33:1:017 · Cited by 58 · see citing works
Serum brain‐derived neurotrophic factor levels in epilepsy
Hong, Z., Li, W., Qu, B., Zou, X., Chen, J., Sander, J. W. A. S., & Zhou, D. (2013) · European Journal of Neurology · doi:10.1111/ene.12232 · Cited by 56 · see citing works
Marić, N. P., & Adžić, M. (2013) · PubMed · Cited by 55 · see citing works
Baj, G., Turco, D. D., Schlaudraff, J., Torelli, L., Deller, T., & Tongiorgi, E. (2013) · Hippocampus · doi:10.1002/hipo.22100 · Cited by 55 · see citing works
Maynard, K. R., Hobbs, J. W., Sukumar, M., Kardian, A., Jimenez, D. V., Schloesser, R. J., & Martinowich, K. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1405-3 · Cited by 51 · see citing works
The prognostic role of electrocorticography in tailored temporal lobe surgery
San‐Juan, D., Tapia, C. E. A., Maricarmen, G.-A. F., Adriana, M. M., Richard, J. S., & Alonso‐Vanegas, M. (2011) · Seizure · doi:10.1016/j.seizure.2011.04.006 · Cited by 49 · see citing works
Self-citationHow common is brain atrophy in patients with medial temporal lobe epilepsy?
Bonilha, L., Elm, J. J., Edwards, J. C., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02576.x · Cited by 44 · see citing works
Neurotrophins in Mesial Temporal Lobe Epilepsy With and Without Psychiatric Comorbidities
Kandratavicius, L., Monteiro, M. R., Assirati, J. A., Carlotti, C. G., Hallak, J. E. C., & Leite, J. P. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000002 · Cited by 40 · see citing works
Expression of p-CREB and activity-dependent miR-132 in temporal lobe epilepsy.
Guo, J., Wang, H., Wang, Q., Chen, Y., & Chen, S. (2014) · Europe PMC (PubMed Central) · Cited by 37 · see citing works
Jardim, A. P., Neves, R. S. D. C., Caboclo, L. O. S. F., Lancellotti, C. L. P., Marinho, M. M., Centeno, R. S., Cavalheiro, É. A., Scorza, C. A., & Yacubian, E. M. T. (2012) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2012000500003 · Cited by 36 · see citing works
Lavebratt, C., Trifunovski, A., Persson, A., Wang, F., Klason, T., Öhman, I., Josephsson, A., Olson, L., Spenger, C., & Schalling, M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.07.018 · Cited by 35 · see citing works
Martínez-Levy, G. A., Rocha, L., Lubin, F. D., Alonso-Vanegas, M. A., Nani, A., Buentello-García, R. M., Pérez-Molina, R., Briones-Velasco, M., Recillas-Targa, F., Pérez-Molina, A., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.046 · Cited by 33 · see citing works
Self-citationNyakas, C., de Kloet, E. R., Veldhuis, H. D., et al. (1983) · Brain Research · doi:10.1016/0006-8993(83)90097-5 · Cited by 32 · see citing works
Park, S. W., Lee, J. G., Seo, M. K., Cho, H. Y., Lee, C. H., Lee, J. H., Lee, B. J., Baek, J. H., Seol, W., & Kim, Y. H. (2014) · Bipolar Disorders · doi:10.1111/bdi.12262 · Cited by 32 · see citing works
Martínez-Levy, G. A., & Cruz-Fuentes, C. S. (2014) · PubMed · Cited by 30 · see citing works
Self-citationZhu, X., Dubey, D., Bermudez, C. L., & Porter, B. E. (2015) · Epilepsia · doi:10.1111/epi.13211 · Cited by 30 · see citing works
Low Dose of Valproate Improves Motor Function after Traumatic Brain Injury
Tai, Y., Lee, W.-Y., Lee, F., Lin, T.-J., Shih, C.-L., Wang, J., Chiu, W., & Hung, K.-S. (2014) · BioMed Research International · doi:10.1155/2014/980657 · Cited by 29 · see citing works
Aliaga, E., Mendoza, I. E., & Tapia‐Arancibia, L. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0159-8 · Cited by 28 · see citing works
Chronic activation of CREB and p90RSK in human epileptic hippocampus
Park, S. A., Kim, T. S., Choi, K. S., Park, H. J., Heo, K., & Lee, B. I. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.48 · Cited by 25 · see citing works
Clark, M., Smith, M. A., Weiss, S. R. B., & Post, R. M. (2008) · Neuroendocrinology · doi:10.1159/000126691 · Cited by 25 · see citing works
Efficient use of a translation start codon in BDNF exon I
Koppel, I., Tuvikene, J., Lekk, I., & Timmusk, T. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13124 · Cited by 24 · see citing works
Jiang, X., Zhou, J., Mash, D. C., Marini, A. M., & Lipsky, R. H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8051-0 · Cited by 24 · see citing works
Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice
Bhowmik, M., Saini, N., & Vohora, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.012 · Cited by 23 · see citing works
Croce, N., Mathé, A. A., Gelfo, F., Caltagirone, C., Bernardini, S., & Angelucci, F. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114529379 · Cited by 21 · see citing works
Zhang, L., Hou, X., & Wang, X. (2010) · Neurology India · doi:10.4103/0028-3886.60392 · Cited by 18 · see citing works
Wang, L., Zhou, C., Zhu, Q. N., Luo, J., Xu, Y., Huang, Y., Zhang, X., & Wang, X. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.09.009 · Cited by 16 · see citing works
Hwang, I. K., Lee, Y.-B., Yoo, K., et al. (2005) · Neuroscience Research · doi:10.1016/j.neures.2005.05.006 · Cited by 16 · see citing works
Phencyclidine rapidly decreases neuronal mRNA of brain-derived neurotrophic factor
Katanuma, Y., Numakawa, T., Adachi, N., Yamamoto, N., Ooshima, Y., Odaka, H., Inoue, T., & Kunugi, H. (2014) · Synapse · doi:10.1002/syn.21735 · Cited by 14 · see citing works
Errami, M., Tassa, A., Galindo, C. L., et al. (2010) · Heart International · doi:10.4081/hi.2010.e7 · Cited by 9 · see citing works
Basta‐Kaim, A., Budziszewska, B., Jaworska-Feil, L., Leśkiewicz, M., Tetich, M., Kubera, M., Scharpé, S., & Lasoń, W. (2003) · PubMed · Cited by 6 · see citing works
Changes of glucocorticoid receptor mRNA expression in basolateral amygdale-kindled rats.
Bao, G., Cheng, X.-Q., Hua, Y., et al. (2011) · PubMed · Cited by 5 · see citing works
Gajzer, D. C., Ross, J., Winder, L., Navada, S. C., Zhang, W., Silverman, L., & Chaurasia, P. (2015) · Vox Sanguinis · doi:10.1111/vox.12303 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
- Authors
- Martínez-Levy, G. A., Rocha, L., Rodríguez-Pineda, F., Alonso-Vanegas, M. A., Nani, A., Buentello-García, R. M., Briones-Velasco, M., San-Juan, D., Cienfuegos, J., & Cruz-Fuentes, C. S.
- Affiliations
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Corresponding author
- Cruz-Fuentes, C. S.
- Venue
- Molecular Neurobiology
- Published
- 2017-05-19
- Volume
- 55
- Issue
- 5
- Pages
- 3698-3708
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2615442414
- Cited by
- 37
- References
- 93
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 1
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Directorate for Biological Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- temporal lobe epilepsy, brain-derived neurotrophic factor, glucocorticoid receptor, temporal cortex, hippocampal atrophy, drug-resistant epilepsy, selective serotonin reuptake inhibitors, carbamazepine, valproic acid, gene expression, synaptic plasticity
- MeSH terms
- Adolescent, Aged, Cerebral Cortex, Epilepsy, Temporal Lobe, Female, Humans, Male, Middle Aged, Receptors, Glucocorticoid, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
