Cited by 194Cytokine Signaling Pathways and InteractionsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

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The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?

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Ceyzériat, Kelly, Abjean, Laurene, Carrillo-de Sauvage, María-Angeles, Ben Haim, Lucile, Escartin, Carole·2016·Neuroscience

DOI 10.1016/j.neuroscience.2016.05.043

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Abstract

Astrocytes play multiple important roles in brain physiology. In pathological conditions, they become reactive, which is characterized by morphological changes and upregulation of intermediate filament proteins. Besides these descriptive hallmarks, astrocyte reactivity involves significant transcriptional and functional changes that are far from being fully understood. Most importantly, astrocyte reactivity seems to encompass multiple states, each having a specific influence on surrounding cells and disease progression. These diverse functional states of reactivity must be regulated by subtle signaling networks. Many signaling cascades have been associated with astrocyte reactivity, but among them, the JAK-STAT3 pathway is emerging as a central regulator. In this review, we aim (i) to show that the JAK-STAT3 pathway plays a key role in the control of astrocyte reactivity, (ii) to illustrate that STAT3 is a pleiotropic molecule operating multiple functions in reactive astrocytes, and (iii) to suggest that each specific functional state of reactivity is governed by complex molecular interactions within astrocytes, which converge on STAT3. More research is needed to precisely identify the signaling networks controlling the diverse states of astrocyte reactivity. Only then, we will be able to precisely delineate the therapeutic potential of reactive astrocytes in each neurological disease context.

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Additional file 4 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 5 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 7 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 6 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 9 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 8 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 2 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 1 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 3 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
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Additional file 1 of HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats
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Authors: Ceyzériat, K., Abjean, L., Carrillo-de Sauvage, M.-A., Ben Haim, L., & Escartin, C.
Affiliations: Université Paris-Sud (FR)
ORCID: Ceyzériat, Kelly
Abjean, Laurene
Escartin, Carole
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2016-08
Volume: 330
Pages: 205-218
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2016.05.043
OpenAlex: W2400419369
Cited by: 185
References: 141
Citations by year: 2026: 14 · 2025: 19 · 2024: 18 · 2023: 30 · 2022: 22 · 2021: 25 · 2020: 19 · 2019: 16 · 2018: 14 · 2017: 8
FWCI: 1.27
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Funders: Agence Nationale de la Recherche (ANR-10-JCJC-1402, 2011-BSV4-021-03)
Centre National de la Recherche Scientifique
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: astrocyte activation, JAK/STAT3 signaling, STAT3, reactive astrocytes, intermediate filament proteins, neurological disorders
MeSH terms: Animals, Astrocytes, Humans, Signal Transduction, STAT3 Transcription Factor, Janus Kinases

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The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?

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