STATs and Gene Regulation

Darnell, James E.

doi:10.1126/science.277.5332.1630

Cited by 3,979Cytokine Signaling Pathways and InteractionsGenomics and Chromatin DynamicsProtein Tyrosine Phosphatases

STATs and Gene Regulation

Darnell, James E.·1997·Science

DOI 10.1126/science.277.5332.1630

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Abstract

STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic explorations have defined a single tyrosine phosphorylation site and, in a dimeric partner molecule, an Src homology 2 (SH2) phosphotyrosine-binding domain, a DNA interaction domain, and a number of protein-protein interaction domains (with receptors, other transcription factors, the transcription machinery, and perhaps a tyrosine phosphatase). Mouse genetics experiments have defined crucial roles for each known mammalian STAT. The discovery of a STAT in Drosophila , and most recently in Dictyostelium discoideum , implies an ancient evolutionary origin for this dual-function set of proteins.

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STAT3 belongs to the family of STAT transcription factors which mediate the cellular response to a variety of cytokines and growth factors including IL-6.
“Signal transducer and activator of transcription 3 (STAT3) belongs to the family of STAT transcription factors which mediate the cellular response to a variety of cytokines and growth factors including IL-6 (6-8”
From STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration (2002) · cites this paper as [7]

STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
Caldenhoven, E., van Dijk, T. B., Solari, R., Armstrong, J., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L., & de Groot, R. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13221 · Cited by 373 · see citing works
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.
Haspel, R. L., Salditt‐Georgieff, M., & Darnell, J. E. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01016.x · Cited by 312 · see citing works
Stat1 Depends on Transcriptional Synergy with Sp1
Look, D. C., Pelletier, M. R., Tidwell, R. M., Roswit, W. T., & Holtzman, M. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30264 · Cited by 268 · see citing works

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HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932 · see citing works
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Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620 · see citing works
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Imada, K., & Leonard, W. J. (2000) · Molecular Immunology · doi:10.1016/s0161-5890(00)00018-3 · Cited by 610 · see citing works
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Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584 · see citing works
Stat1-dependent and -independent pathways in IFN-γ-dependent signaling
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Roles of unphosphorylated STATs in signaling
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Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family
de Groot, R. P., Coffer, P. J., & Koenderman, L. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00023-0 · Cited by 215 · see citing works
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Haspel, R. L., & Darnell, J. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10188 · Cited by 203 · see citing works
The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?
Ceyzériat, K., Abjean, L., Carrillo-de Sauvage, M.-A., Ben Haim, L., & Escartin, C. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.043 · Cited by 185 · see citing works
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DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1
Meyer, T., Marg, A., Lemke, P., Wiesner, B., & Vinkemeier, U. (2003) · Genes & Development · doi:10.1101/gad.268003 · Cited by 161 · see citing works
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Yeh, M., Gharavi, N. M., Choi, J., Hsieh, X., Reed, E., Mouillesseaux, K. P., Cole, A. L., Reddy, S. T., & Berliner, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312198200 · Cited by 116 · see citing works
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Goedken, E. R., Argiriadi, M. A., Banach, D. L., Fiamengo, B. A., Foley, S. E., Frank, K. E., George, J. S., Harris, C. M., Hobson, A. D., Ihle, D. C., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.595181 · Cited by 101 · see citing works
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Quintanilla-Martinez, L., Kremer, M., Specht, K., Calzada-Wack, J., Nathrath, M., Schaich, R., Höfler, H., & Fend, F. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64278-2 · Cited by 93 · see citing works
Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α
Schmidt, M., Hochhaus, A., Nitsche, A., Hehlmann, R., & Neubauer, A. (2001) · Blood · doi:10.1182/blood.v97.11.3648 · Cited by 77 · see citing works
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Contursi, C., Wang, I.-M., Gabriele, L., Gadina, M., O'Shea, J., Morse, H. C., & Ozato, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.91 · Cited by 72 · see citing works
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TIMMER, J., MÜLLER, T. G., SWAMEYE, I., SANDRA, O., & KLINGMÜLLER, U. (2004) · International Journal of Bifurcation and Chaos · doi:10.1142/s0218127404010461 · Cited by 68 · see citing works
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A model for modulation of leptin activity by association with clusterin
Bajari, T. M., Strasser, V., Nimpf, J., & Schneider, W. J. (2003) · The FASEB Journal · doi:10.1096/fj.02-1106fje · Cited by 45 · see citing works
Tests for cycling in a signalling pathway
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MAPK signaling during Müller glial cell development in retina explant cultures
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Authors: Darnell, J. E.
Affiliations: The author is in the Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-09-12
Volume: 277
Issue: 5332
Pages: 1630-1635
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.277.5332.1630
OpenAlex: W2083802827
Cited by: 3,979
References: 3
Citations by year: 2026: 46 · 2025: 61 · 2024: 92 · 2023: 104 · 2022: 88 · 2021: 96 · 2020: 85 · 2019: 96 · 2018: 76 · 2017: 111 · 2016: 96 · 2015: 123 · 2014: 152 · 2013: 150 · 2012: 153
FWCI: 94.30
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI 34420, R01AI032489, AI32489)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: STAT proteins, signal transducer and activator of transcription, gene expression regulation, transcriptional regulation, tyrosine phosphorylation, SH2 domain, DNA-binding domain, protein-protein interaction, protein tyrosine phosphatase, transcription factors, mouse genetics, Dictyostelium discoideum
MeSH terms: Animals, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Nuclear Proteins, Phosphorylation, Signal Transduction, Transcriptional Activation, Trans-Activators, src Homology Domains, Phosphotyrosine, Dimerization

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STATs and Gene Regulation

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