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Cited by 74Advanced Neuroimaging Techniques and ApplicationsSchizophrenia research and treatmentFunctional Brain Connectivity Studies

Localized abnormalities in the cingulum bundle in patients with schizophrenia: a diffusion tensor tractography study

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Whitford, Thomas J., Lee, Sun Woo, Oh, Jungsu S., de Luis-Garcia, Rodrigo, Savadjiev, Peter, Alvarado, Jorge L., Westin, Carl-Fredrik, Niznikiewicz, Margaret +4 more·2014·NeuroImage: Clinical
DOI 10.1016/j.nicl.2014.06.003PMC PMC4081981
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Abstract

The cingulum bundle (CB) connects gray matter structures of the limbic system and as such has been implicated in the etiology of schizophrenia. There is growing evidence to suggest that the CB is actually comprised of a conglomeration of discrete sub-connections. The present study aimed to use Diffusion Tensor tractography to subdivide the CB into its constituent sub-connections, and to investigate the structural integrity of these sub-connections in patients with schizophrenia and matched healthy controls. Diffusion Tensor Imaging scans were acquired from 24 patients diagnosed with chronic schizophrenia and 26 matched healthy controls. Deterministic tractography was used in conjunction with FreeSurfer-based regions-of-interest to subdivide the CB into 5 sub-connections (I1 to I5). The patients with schizophrenia exhibited subnormal levels of FA in two cingulum sub-connections, specifically the fibers connecting the rostral and caudal anterior cingulate gyrus (I1) and the fibers connecting the isthmus of the cingulate with the parahippocampal cortex (I4). Furthermore, while FA in the I1 sub-connection was correlated with the severity of patients' positive symptoms (specifically hallucinations and delusions), FA in the I4 sub-connection was correlated with the severity of patients' negative symptoms (specifically affective flattening and anhedonia/asociality). These results support the notion that the CB is a conglomeration of structurally interconnected yet functionally distinct sub-connections, of which only a subset are abnormal in patients with schizophrenia. Furthermore, while acknowledging the fact that the present study only investigated the CB, these results suggest that the positive and negative symptoms of schizophrenia may have distinct neurobiological underpinnings.

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  • In schizophrenia, FA correlations were found between the right genu cingulum and hallucinations.

    “FA correlations were found between the right genu cingulum and hallucinations”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Whitford et al., 2014

    The Results report a significant negative correlation between hallucination severity and FA in the right I1 cingulum sub-connection in patients with schizophrenia. The Methods define I1 as fibers connecting the rostral and caudal anterior cingulate gyri, but the paper does not identify that sub-connection as the right genu cingulum. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Some dMRI studies have added additional cingulum subdivisions.

    “Furthermore, some dMRI studies have added additional cingulum subdivisions (Kennis et al., 2016; Metzler-Baddeley et al., 2012b; Whitford et al., 2014).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Whitford et al., 2014

  • In schizophrenia, cingulum abnormalities are most often seen near the genu but may also occur in the parahippocampal cingulum.

    “while cingulum abnormalities are most often seen near the genu, they may also occur in the parahippocampal cingulum (e.g. Whitford et al., 2014).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Whitford et al., 2014

  • In schizophrenia, right parahippocampal cingulum status correlated with negative symptoms.

    “while right parahippocampal cingulum status correlated with negative symptoms (Whitford et al., 2014).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Whitford et al., 2014

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Authors
Whitford, T. J., Lee, S. W., Oh, J. S., de Luis-Garcia, R., Savadjiev, P., Alvarado, J. L., Westin, C.-F., Niznikiewicz, M., Nestor, P. G., McCarley, R. W., Kubicki, M., & Shenton, M. E.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
Shenton, Martha E.
ORCID
Venue
NeuroImage: Clinical
Publisher
Elsevier BV
Published
2014
Volume
5
Pages
93-99
ISSN
2213-1582 (ISSN-L)
DOI
10.1016/j.nicl.2014.06.003
PMC
PMC4081981
OpenAlex
W2151593200
Cited by
74
References
2
Citations by year
2026: 2 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 3 · 2014: 1
FWCI
4.96
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Health and Medical Research Council (520627)
  • Brain and Behavior Research Foundation (17537)
  • Chungnam National University
  • Seoul National University (BK21)
  • Spanish MEC/Fulbright Commission (2007–1238)
  • National Institutes of Health (R01 MH074794, U54 EB005149, K05 MH 070047, R01 MH 50747)
  • U.S. Department of Veterans Affairs
  • Center for Intervention Development and Applied Research (CIDAR) (P50 MH 080272)
  • National Institute of Mental Health (MH 040799)
  • Center for Intervention Development and Applied Research (P50 MH 080272)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
cingulum, schizophrenia, anterior cingulate cortex, parahippocampal cortex, fractional anisotropy, positive symptoms, negative symptoms, hallucinations, delusions, affective flattening, anhedonia, limbic system
MeSH terms
Adult, Brain Mapping, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Schizophrenia, Anisotropy, Diffusion Tensor Imaging

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