Interaction of language, auditory and memory brain networks in auditory verbal hallucinations
Open accessAbstract
Auditory verbal hallucinations (AVH) occur in psychotic disorders, but also as a symptom of other conditions and even in healthy people. Several current theories on the origin of AVH converge, with neuroimaging studies suggesting that the language, auditory and memory/limbic networks are of particular relevance. However, reconciliation of these theories with experimental evidence is missing. We review 50 studies investigating functional (EEG and fMRI) and anatomic (diffusion tensor imaging) connectivity in these networks, and explore the evidence supporting abnormal connectivity in these networks associated with AVH. We distinguish between functional connectivity during an actual hallucination experience (symptom capture) and functional connectivity during either the resting state or a task comparing individuals who hallucinate with those who do not (symptom association studies). Symptom capture studies clearly reveal a pattern of increased coupling among the auditory, language and striatal regions. Anatomical and symptom association functional studies suggest that the interhemispheric connectivity between posterior auditory regions may depend on the phase of illness, with increases in non-psychotic individuals and first episode patients and decreases in chronic patients. Leading hypotheses involving concepts as unstable memories, source monitoring, top-down attention, and hybrid models of hallucinations are supported in part by the published connectivity data, although several caveats and inconsistencies remain. Specifically, possible changes in fronto-temporal connectivity are still under debate. Precise hypotheses concerning the directionality of connections deduced from current theoretical approaches should be tested using experimental approaches that allow for discrimination of competing hypotheses.
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Evidence supports the hypothesis that hallucinations arise from release of sensory signals by reduced top-down inhibition from higher-order centers such as frontal areas and their connections with the thalamus.
“In addition, evidence supports the hypothesis that hallucinations arise from release of those sensory signals by reduced top-down inhibition from higher-order centers such as frontal areas and their connections with the thalamus. 40-43”
From Towards an Integrative Account of Potential Mechanisms Mediating the Path From Sleep Dysfunction to Hallucinations (2025) · cites this paper as [41]
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“However, decreases in FA do not always imply aberrant integrity, but can also indicate crossing fibers (see for example (Hoeft et al., 2007; Soares et al., 2013)).”
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Auditory verbal hallucinations predominantly activate the right inferior frontal area
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“This is consistent with ‘over-activation’ of Broca’s area during AVH (Sommer et al., 2008).”
ResultSelf-citationEncoding novel face‐name associations: A functional MRI study
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“In patients with schizophrenia, errors already occur at the perception level (Gold et al., 1992).”
BackgroundPicard, H., Amado, I., Mouchet-Mages, S., Olié, J., & Krebs, M. (2007) · Schizophrenia bulletin · doi:10.1093/schbul/sbm049 · Cited by 290 · cited 1× · see citing works
“Cerebellum is important for brain synchrony and action prediction (D'Angelo and Casali, 2013) by coordinating and modulating cortical activity (Picard et al., 2008).”
BackgroundHallucinations: The science of idiosyncratic perception.
Aleman, A., & Larøi, F. (2008) · American Psychological Association eBooks · doi:10.1037/11751-000 · Cited by 283 · see citing works
McCarthy‐Jones, S., Trauer, T., Mackinnon, A. J., Sims, E., Thomas, N., & Copolov, D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs156 · Cited by 282 · cited 1× · see citing works
“, command hallucinations, third-person hallucinations, and thought echo (Blom and Sommer, 2010; McCarthy-Jones et al., 2014).”
BackgroundKompus, K., Westerhausen, R., & Hugdahl, K. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.08.010 · Cited by 274 · see citing works
The neurophysics of consciousness
John, E. R. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00142-x · Cited by 262 · cited 1× · see citing works
“The application of FC analyses to the study of AVHs is motivated by a range of studies demonstrating that inter-region functional coordination plays an important role in determining whether neural activity is experienced consciously as percepts (Cosmelli et al., 2004; Sergent and Dehaene, 2004; Melloni et al., 2007; J…”
MethodVercammen, A., Knegtering, H., den Boer, J. A., Liemburg, E. J., & Aleman, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.017 · Cited by 261 · cited 2× · see citing works
“Symptom association studies Vercammen and colleagues used a region of interest analysis comprising neuronal networks involved in inner speech processing, based around a seed region in the tempo-parietal junction (Vercammen et al., 2010).”
BackgroundMeta-analysis of corpus callosum size in schizophrenia.
Woodruff, P. W. R., McManus, I. C., & David, A. S. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.4.457 · Cited by 255 · see citing works
A Diffusion Tensor Imaging Study of Fasciculi in Schizophrenia
Shergill, S. S., Kanaan, R., Chitnis, X. A., O’Daly, O., Jones, D. K., Frangou, S., Williams, S. C., Howard, R. J., Barker, G. J., Murray, R. M. L., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.3.467 · Cited by 254 · cited 4× · see citing works
“Decreased FA in various parts of the cingulum has consistently been observed in schizophrenia patients (Hubl et al., 2004; Shergill et al., 2007; Knöchel et al., 2012).”
BackgroundInfluentialIntrusive Thoughts and Auditory Hallucinations: A Cognitive Approach
Morrison, A. P., Haddock, G., & Tarrier, N. (1995) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465800015873 · Cited by 252 · cited 1× · see citing works
“In support, people who hear voices experience these as intrusive and unwanted (Morrison et al., 1995), as might be expected if memory systems fail to suppress mental associations which are not currently relevant.”
BackgroundForkel, S. J., Thiebaut de Schotten, M., Kawadler, J. M., Dell'Acqua, F., Danek, A., & Catani, M. (2014) · Cortex · doi:10.1016/j.cortex.2012.09.005 · Cited by 248 · cited 1× · see citing works
“Another important tract involved in language processing is the inferior fronto-occipital fasciculus, connecting frontal with temporal and parietal parts of the brain and running inferior to the AF (Forkel et al., 2012).”
BackgroundHyperconnectivity is a fundamental response to neurological disruption.
Hillary, F. G., Román, C. A. F., Venkatesan, U. M., Rajtmajer, S. M., Bajo, R., & Castellanos, N. P. (2014) · Neuropsychology · doi:10.1037/neu0000110 · Cited by 248 · cited 2× · see citing works
“Their review of 126 studies showed that after the onset of illness overall connectivity is increased but diminishes in the later stages of the degeneration (Hillary et al., 2015).”
BackgroundResultSynch before you speak: Auditory hallucinations in schizophrenia
Ford, J. M., Roach, B. J., Faustman, W. O., & Mathalon, D. H. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.458 · Cited by 245 · cited 2× · see citing works
“suppression, as the degree of connectivity between these areas during talking is related to the degree of suppression (Ford et al., 2007; Chen et al., 2011; Wang et al., 2014).”
BackgroundSelf-citationKuhn, S., & Gallinat, J. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq152 · Cited by 245 · cited 1× · see citing works
“The STG (left and right) are almost universally active during AVH (Jardri et al., 2011; Kuhn and Gallinat, 2010).”
BackgroundSzeszko, P. R., Robinson, D. G., Ashtari, M., Vogel, J., Betensky, J. D., Sevy, S. M., Ardekani, B. A., Lencz, T., Malhotra, A. K., McCormack, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301480 · Cited by 241 · see citing works
Allen, P., Modinos, G., Hubl, D., Shields, G., Cachia, A., Jardri, R., Thomas, P., Woodward, T., Shotbolt, P., Plaze, M., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs066 · Cited by 240 · cited 7× · see citing works
“Functional MRI studies have investigated the functional brain networks during the experience of hallucinations but also compared the functional brain networks between patients who hallucinate and those that do not, based on reports of hearing hallucination during the past (Allen et al., 2012; Woodruff, 2004).”
BackgroundInfluentialAuditory hallucinations in schizophrenia: intrusive thoughts and forgotten memories
Waters, F., Badcock, J., Michie, P., & Maybery, M. (2006) · Cognitive Neuropsychiatry · doi:10.1080/13546800444000191 · Cited by 233 · cited 1× · see citing works
“Inhibitory deficits would also contribute to the failure to control the contents of memories (Jardri et al., 2016; Waters et al., 2006).”
BackgroundGallinat, J., Winterer, G., Herrmann, C. S., & Senkowski, D. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.03.013 · Cited by 230 · cited 1× · see citing works
“In principle, the pathophysiology of AVH thus predict impaired EEG synchronisation during sensory processing in patient s with AVH, as shown in a series of studies (Kwon et al., 1999; Gallinat et al., 2004; Uhlhaas et al., 2008; Uhlhaas and Singer, 2010; Engel et al., 2013).”
ResultModinos, G., Costafreda, S. G., van Tol, M., McGuire, P. K., Aleman, A., & Allen, P. (2012) · Cortex · doi:10.1016/j.cortex.2012.01.009 · Cited by 230 · cited 1× · see citing works
“Furthermore, decreases in the primary (Modinos et al., 2013) and secondary auditory cortex GM volume (reviewed by Allen et al.”
BackgroundAbnormal brain white matter in schizophrenia: a diffusion tensor imaging study
Agartz, I., Andersson, J., & Skare, S. T. (2001) · Neuroreport · doi:10.1097/00001756-200107200-00041 · Cited by 225 · see citing works
Mhuircheartaigh, R. N., Rosenorn-Lanng, D., Wise, R. G., Jbabdi, S., Rogers, R., & Tracey, I. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5516-09.2010 · Cited by 205 · cited 1× · see citing works
“1), and the putamen to translate memories into language experience (Price, 2010) and bring the experience into consciousness (Mhuircheartaigh et al., 2010), as well as speech and auditory network (Wernicke’s, Broca’s areas; Fig.”
BackgroundNorthoff, G., & Qin, P. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.11.009 · Cited by 205 · cited 3× · see citing works
“Northoff predicts that elevated resting state activity in the default mode network and auditory cortex coupled with their unaltered communication can enhance the development of AVH (Northoff, 2014; Northoff and Qin, 2011).”
BackgroundResultWhite Matter Development in Adolescence: Diffusion Tensor Imaging and Meta-Analytic Results
Peters, B. D., Szeszko, P. R., Raduà, J., Ikuta, T., Gruner, P., DeRosse, P., Zhang, J., Giorgio, A., Qiu, D., Tapert, S. F., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs054 · Cited by 203 · cited 1× · see citing works
“An increase in the total number of whole-brain DTI studies referring to validated whitematter templates would pave the way to coordinate-based metaanalyses, providing a peak effect size and signed maps of positive or negative differences in AVH patients (Peters et al., 2012).”
BackgroundTop-down and bottom-up processes in speech comprehension
Zekveld, A. A., Heslenfeld, D. J., Festen, J. M., & Schoonhoven, R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.199 · Cited by 203 · see citing works
Deactivation of the Parahippocampal Gyrus Preceding Auditory Hallucinations in Schizophrenia
Diederen, K. M. J., Neggers, S. F. W., Daalman, K., Blom, J. D., Goekoop, R., Kahn, R. S., & Sommer, I. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09040456 · Cited by 202 · see citing works
Hallucinations and perceptual inference
Friston, K. J. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05290131 · Cited by 196 · see citing works
How hallucinations may arise from brain mechanisms of learning, attention, and volition
Grossberg, S. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770065508x · Cited by 192 · cited 2× · see citing works
“This is in line with abnormal top-down influences on auditory perception in the case of hallucinatory experiences (Behrendt, 2006; Grossberg, 2000), as described in Section 3.”
BackgroundHugdahl, K. (2009) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.2009.00775.x · Cited by 188 · cited 1× · see citing works
“also endorsed the idea of an imbalance in top-down/bottom-up influences and suggested that while AVHs originate in perisylvian regions (Hugdahl, 2009), they are in general not as constrained by the PFC in patients as they are in non-psychotic voice-hearers.”
Allen, P., Aleman, A., & Mcguire, P. K. (2007) · International Review of Psychiatry · doi:10.1080/09540260701486498 · Cited by 188 · cited 1× · see citing works
“Source monitoring hypothesis proposes that AVH comprise deficits in self-monitoring and reality discrimination (Bentall and Slade, 1985; McGuire et al., 1993; Allen et al., 2007), whereby internally events (thoughts, inner speech, actions) lack ‘self’ attributes, resulting in broad difficulties in self-recognition.”
BackgroundSelf-citationCognitive basis of hallucinations in schizophrenia: role of top-down information processing
Aleman, A., Böcker, K. B. E., Hijman, R., de Haan, E. H. F., & Kahn, R. S. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00060-4 · Cited by 178 · cited 2× · see citing works
“Another approach that focuses on perception and attentional processes is based on the idea that AVH may be caused by unbalanced mechanisms for bottom-up sensory processing on one hand and top-down mechanisms on the other hand (Behrendt, 1998; Grossberg, 2000; Aleman et al., 2003).”
BackgroundThe Neurodynamic Organization of Modality-Dependent Hallucinations
Jardri, R., Thomas, P., Delmaire, C., Delion, P., & Pins, D. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs082 · Cited by 177 · cited 1× · see citing works
“found that primary auditory cortex was not systematically active during AVH but when active, this was linked with increased vividness in hallucinatory experiences (Jardri et al., 2013).”
BackgroundMisattribution of speech and impaired connectivity in patients with auditory verbal hallucinations
Mechelli, A., Allen, P., Amaro, E., Fu, C. H. Y., Williams, S. C. R., Brammer, M. J., Johns, L. C., & McGuire, P. K. (2007) · Human Brain Mapping · doi:10.1002/hbm.20341 · Cited by 175 · cited 5× · see citing works
“One study used effective connectivity between monitoring and language areas and interpreted their findings as evidence of source monitoring deficits in the people with AVH and as support for the self-monitoring deficit theory of AVH (Mechelli et al., 2007).”
BackgroundResultInfluentialKindler, J., Hubl, D., Strik, W. K., Dierks, T., & Koenig, T. W. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.10.042 · Cited by 170 · cited 1× · see citing works
“demonstrated the shortening of class D microstates during AVH (Kindler et al., 2011).”
BackgroundSeok, J.-H., Park, H.-J., Chun, J.-W., Lee, S.-K., Cho, H. S., Kwon, J. S., & Kim, J.-J. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.02.002 · Cited by 168 · cited 3× · see citing works
“These authors reported a positive correlation between AVH severity and the left superior longitudinal fasciculus FA – the region with the highest white matter density in AVH compared to all other groups (Seok et al., 2007).”
ResultAlderson-Day, B., McCarthy-Jones, S., & Fernyhough, C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.016 · Cited by 165 · see citing works
Long-range synchrony of gamma oscillations and auditory hallucination symptoms in schizophrenia
Mulert, C., Kirsch, V., Pascual-Marqui, R., McCarley, R. W., & Spencer, K. M. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.08.004 · Cited by 165 · see citing works
Self-citationBenoit, R. G., Hulbert, J. C., Huddleston, E., & Anderson, M. C. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00696 · Cited by 158 · cited 1× · see citing works
“Memory fragments are usually inhibited during focused attention (Benoit et al., 2015), but may become less inhibited during times of daydreaming and relaxation, when the default mode network is more active.”
BackgroundAre hallucinations due to an imbalance between excitatory and inhibitory influences on the brain?
Jardri, R., Hugdahl, K., Hughes, M., Brunelin, J., Waters, F., Alderson-Day, B., Smailes, D., Sterzer, P., Corlett, P. R., Leptourgos, P., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw075 · Cited by 157 · see citing works
Self-citationHoffman, R. E., Fernandez, T., Pittman, B., & Hampson, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.050 · Cited by 156 · see citing works
Childhood trauma and auditory verbal hallucinations
Daalman, K., Diederen, K. M. J., Derks, E. M., van Lutterveld, R., Kahn, R. S., & Sommer, I. E. C. (2012) · Psychological Medicine · doi:10.1017/s0033291712000761 · Cited by 153 · cited 2× · see citing works
“This theory could provide a neurobiological explanation for the strong association between childhood trauma and AVH, which is present in patients with schizophrenia, with post-traumatic stress disorder and also in non-clinical populations (Daalman et al., 2012).”
BackgroundRole of the Corpus Callosum in Speech Comprehension: Interfacing Syntax and Prosody
Friederici, A. D., von Cramon, D. Y., & Kotz, S. A. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.020 · Cited by 148 · cited 1× · see citing works
“For example, lesion studies demonstrated a crucial role of this pathway in the integration of prosodic and syntactic information (Friederici et al., 2007).”
BackgroundThe multimodal connectivity of the hippocampal complex in auditory and visual hallucinations
Amad, A., Cachia, A., Gorwood, P. A. P. M., Pins, D., Delmaire, C., Rolland, B., Mondino, M., Thomas, P., & Jardri, R. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.181 · Cited by 137 · cited 1× · see citing works
“(Amad et al., 2014) examined connectivity between the hippocampal complex and other regions that included STG in patients with auditory, and patients with auditory”
BackgroundNeural activity in speech-sensitive auditory cortex during silence
Hunter, M. D., Eickhoff, S. B., Miller, T. W. R., Farrow, T. F. D., Wilkinson, I. D., & Woodruff, P. W. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506268103 · Cited by 132 · cited 2× · see citing works
“, who showed increased activity during rest in auditory sensory areas of people more prone to hallucinate (Hunter et al., 2006).”
BackgroundRotarska-Jagiela, A., Oertel‐Knoechel, V., Martino, F. D., van de Ven, V. G., Formisano, E., Roebroeck, A. F., Rami, A., Schoenmeyer, R., Haenschel, C., Hendler, T., et al. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.03.002 · Cited by 131 · see citing works
Waves of consciousness: ongoing cortical patterns during binocular rivalry
Cosmelli, D., David, O., Lachaux, J.-P., Martinerie, J., Garnero, L., Renault, B., & Varela, F. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.05.008 · Cited by 131 · cited 1× · see citing works
“The application of FC analyses to the study of AVHs is motivated by a range of studies demonstrating that inter-region functional coordination plays an important role in determining whether neural activity is experienced consciously as percepts (Cosmelli et al., 2004; Sergent and Dehaene, 2004; Melloni et al., 2007; J…”
MethodCui, L., Liu, K., Li, C., Wang, L., Guo, F., Tian, P., Wu, Y.-J., Guo, L., Liu, W.-M., Xi, Y., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.02.039 · Cited by 131 · see citing works
Catani, M., Craig, M., Forkel, S. J., Kanaan, R., Picchioni, M., Toulopoulou, T., Shergill, S. S., Williams, S., Murphy, D., & McGuire, P. K. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.013 · Cited by 129 · cited 2× · see citing works
“, 2007), whereas others demonstrate a decrease in fractional anisotropy (FA), implicating decreased connectivity (Catani et al., 2011; De Weijer et al., 2013; Cur9 ci c-Blake et al., 2015) in the same pathway within the network (Geoffroy et al.”
BackgroundResultAlderson‐Day, B., Diederen, K. M. J., Fernyhough, C., Ford, J. M., Horga, G., Margulies, D. S., McCarthy‐Jones, S., Northoff, G., Shine, J. M., Turner, J. A., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw078 · Cited by 129 · cited 2× · see citing works
“It is possible that the differences arise from different measurement or analysis techniques (Alderson-Day et al., 2016), or the use of different questionnaires.”
BackgroundShinn, A. K., Baker, J. T., Cohen, B. M., & Öngür, D. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.037 · Cited by 128 · cited 3× · see citing works
“Shinn and colleagues reported contradictory results (Shinn et al., 2013).”
BackgroundInfluentialAlonso-Solís, A., Vives‐Gilabert, Y., Grasa, E., Portella, M. J., Rabella, M., Sauras-Quetcuti, R. B., Roldán, A., Núñez-Marín, F., Gómez‐Ansón, B., Pérez, V., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.10.047 · Cited by 124 · see citing works
Gavrilescu, M., Rossell, S., Stuart, G. W., Shea, T. L., Innes-Brown, H., Henshall, K., McKay, C., Sergejew, A. A., Copolov, D., & Egan, G. F. (2010) · Psychological Medicine · doi:10.1017/s0033291709991632 · Cited by 121 · cited 1× · see citing works
“Using RS fMRI, Gavrilescu and colleagues investigated interhemispheric connectivity in the primary and secondary auditory cortex in patients with and without AVH and healthy controls (Gavrilescu et al., 2010).”
BackgroundParacingulate sulcus morphology is associated with hallucinations in the human brain
Garrison, J. R., Fernyhough, C., McCarthy‐Jones, S., Haggard, M. P., Carr, V. J., Schall, U., Scott, R. J., Jablensky, A. V., Mowry, B. J., Patricia, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9956 · Cited by 121 · see citing works
Farhall, J., Greenwood, K. M., & Jackson, H. J. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.12.002 · Cited by 118 · cited 1× · see citing works
“Certainly patients with stressful AVHs find relief by talking to themselves or to others (Nayani and David, 1996; Farhall and Gehrke, 1997; Farhall et al., 2007).”
BackgroundKnöchel, C., Oertel‐Knöchel, V., Schönmeyer, R., Rotarska-Jagiela, A., van de Ven, V. G., Prvulovic, D., Haenschel, C., Uhlhaas, P. J., Pantel, J., Hampel, H. J., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.088 · Cited by 116 · cited 1× · see citing works
“Meanwhile, Knöchel and colleagues investigated FA and mean diffusivity (Knochel et al., 2012), a measure of the compactness of axons and intercellular space (Beaulieu, 2002).”
BackgroundWesterhausen, R., Grüner, R., Specht, K., & Hugdahl, K. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn173 · Cited by 116 · cited 1× · see citing works
“Interestingly, there is a strong relationship between the structure and function of interhemispheric connectivity between the bilateral auditory areas and conscious auditory perception in general (Westerhausen et al., 2009; Steinmann et al., 2014b).”
BackgroundTuning in to the Voices: A Multisite fMRI Study of Auditory Hallucinations
Ford, J. M., Roach, B. J., Jørgensen, K. W., Turner, J. A., Brown, G. G., Notestine, R. J., Bischoff‐Grethe, A., Greve, D. N., Wible, C. G., Lauriello, J., et al. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn140 · Cited by 115 · cited 1× · see citing works
“The observation that auditory hallucinations reduce responsivity to external speech within STG and related regions such as MTG has led to the ‘saturation theory’ whereby the signal driving hallucinations competes for common neurophysiological resources with those used for perceivingexternal speech (Woodruff et al.,199…”
BackgroundA computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia
Woodruff, P. W. R., Pearlson, G. D., Geer, M. J., Barta, P. E., & Chilcoat, H. D. (1993) · Psychological Medicine · doi:10.1017/s0033291700038836 · Cited by 109 · cited 1× · see citing works
“, 1995b) may also be related to delusions which occur in the same condition (Woodruff et al., 1993).”
BackgroundCorrelated neural activity as the driving force for functional changes in auditory cortex
Eggermont, J. J. (2007) · Hearing Research · doi:10.1016/j.heares.2007.01.008 · Cited by 106 · cited 1× · see citing works
“Based on findings of hyper-synchrony between the auditory cortices (Eggermont, 2007), Diesch and colleagues suggested that stronger interhemispheric auditory pathways may facilitate the development and persistence of a positive feedback loop between tinnitus generators located in both hemispheres (Diesch et al.”
BackgroundNot on speaking terms: hallucinations and structural network disconnectivity in schizophrenia
Ćurĉić‐Blake, B., Nanetti, L., van der Meer, L., Cerliani, L., Renken, R. J., Pijnenborg, G. H. M., & Aleman, A. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0663-y · Cited by 104 · see citing works
Resting State Functional Connectivity in Patients with Chronic Hallucinations
Sommer, I. E., Clos, M., Meijering, A. L., Diederen, K. M. J., & Eickhoff, S. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043516 · Cited by 103 · cited 2× · see citing works
“Two studies found evidence for a specific role of connections between memory regions and Broca’s area (the language production area) (Sommer et al., 2012; Diederen et al., 2013) and Hoffman showed that the FC between the putamen and language areas is very important for AVH (Hoffman et al.”
BackgroundIn search of occipital activation during visual mental imagery
Kosslyn, S. M., & Ochsner, K. N. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90059-0 · Cited by 102 · cited 1× · see citing works
“It has been known for some time that imagery activates the brain areas that overlap with those that sub-serve perception (Kosslyn and Ochsner, 1994; Zatorre et al., 2007).”
BackgroundRolland, B., Amad, A., Poulet, E., Bordet, R., Vignaud, A., Bation, R., Delmaire, C., Thomas, P., Cottencin, O., & Jardri, R. (2015) · Schizophrenia bulletin · doi:10.1093/schbul/sbu097 · Cited by 98 · cited 15× · see citing works
“Specifically, two seed-based studies reported hyperconnectivity in networks involving STG and the dACC/SMA for AVH patients relative to NoAVH (Alonso-Solis et al., 2015; Rolland et al., 2015).”
ResultInfluentialTime course of regional brain activation associated with onset of auditory/verbal hallucinations
Hoffman, R. E., Anderson, A. W., Varanko, M., Gore, J. C., & Hampson, M. (2008) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.040501 · Cited by 96 · cited 1× · see citing works
“In support, hippocampal deactivations have been observed immediately prior AVH, pointing to the release of memory (Hoffman et al., 2008; Diederen et al., 2010).”
BackgroundReality of auditory verbal hallucinations
Raij, T. T., Valkonen-Korhonen, M., Holi, M., Therman, S., Lehtonen, J., & Hari, R. (2009) · Brain · doi:10.1093/brain/awp186 · Cited by 95 · see citing works
de Weijer, A. D., Mandl, R. C. W., Diederen, K. M. J., Neggers, S. F. W., Kahn, R. S., Pol, H. E. H., & Sommer, I. E. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.05.010 · Cited by 95 · see citing works
Effective and Structural Connectivity in the Human Auditory Cortex
Upadhyay, J., Silver, A. M., Knaus, T. A., Lindgren, K. A., Ducros, M. G., Kim, D., & Tager-Flusberg, H. B. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4434-07.2008 · Cited by 92 · cited 1× · see citing works
“(Upadhyay et al., 2008) found that passive listening to female voices revealed effective connectivity between primary auditory cortex and anterior and posterior STG, regions that have also been demonstrated to be responsible for attributing externality to perceived speech (Hunter et al.”
BackgroundGeoffroy, P. A., Houenou, J., Duhamel, A., Amad, A., De Weijer, A. D., Ćurčić-Blake, B., Linden, D. E. J., Thomas, P., & Jardri, R. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.014 · Cited by 90 · see citing works
Hearing voices: A role of interhemispheric auditory connectivity?
Mulert, C., Kirsch, V., Whitford, T. J., Alvarado, J., Pelavin, P. E., McCarley, R. W., Kubicki, M. R., Salisbury, D. F., & Shenton, M. E. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.570789 · Cited by 89 · cited 2× · see citing works
“These results suggest that interhemispheric miscommunication between bilateral auditory areas in patients with AVH is already present during the first episode (Hubl et al., 2004; Mulert et al., 2012), but alters during the course of the disease (Wigand et al.”
BackgroundResultThe corollary discharge in humans is related to synchronous neural oscillations
Chen, C.-M. A., Mathalon, D. H., Roach, B. J., Cavus, I., Spencer, D. D., & Ford, J. M. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21589 · Cited by 86 · cited 3× · see citing works
“This can be interpreted as a gamma-band mediated neural instantiation of the transmission of a copy of motor commands (Chen et al., 2011).”
BackgroundSelf-citationA neural basis for the perception of voices in external auditory space
Hunter, M. D., Griffiths, T. D., Farrow, T. F. D., Zheng, Y., Wilkinson, I. D., Hegde, N., Woods, W., Spence, S. A., & Woodruff, P. W. R. (2003) · Brain · doi:10.1093/brain/awg015 · Cited by 85 · see citing works
Action planning and predictive coding when speaking
Wang, J., Mathalon, D., Roach, B., Reilly, J., Keedy, S., Sweeney, J., & Ford, J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.003 · Cited by 85 · cited 2× · see citing works
“These findings suggest that an efference copy from speech areas in prefrontal cortex is transmitted to auditory cortex, where it is used to suppress processing of anticipated speech sounds (Wang et al., 2014).”
BackgroundAuditory hallucinations and perception of external speech
Woodruff, P. W. R., Brammer, M. J., Mellers, J. D. C., Wright, I. C., Bullmore, E. T., Williams, S., Colover, J., Lawrie, S., & Abukmeil, S. S. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91715-2 · Cited by 83 · see citing works
Behrendt, R. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881105057696 · Cited by 83 · cited 1× · see citing works
“This is in line with abnormal top-down influences on auditory perception in the case of hallucinatory experiences (Behrendt, 2006; Grossberg, 2000), as described in Section 3.”
BackgroundCoping with hallucinations: Exploring stress and coping framework
Farhall, J., & Gehrke, M. (1997) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1997.tb01411.x · Cited by 82 · cited 1× · see citing works
“Certainly patients with stressful AVHs find relief by talking to themselves or to others (Nayani and David, 1996; Farhall and Gehrke, 1997; Farhall et al., 2007).”
BackgroundAuditory hallucinations: Insights and questions from neuroimaging
Woodruff, P. W. R. (2004) · Cognitive Neuropsychiatry · doi:10.1080/13546800344000165 · Cited by 82 · cited 1× · see citing works
“Functional MRI studies have investigated the functional brain networks during the experience of hallucinations but also compared the functional brain networks between patients who hallucinate and those that do not, based on reports of hearing hallucination during the past (Allen et al., 2012; Woodruff, 2004).”
Backgroundde Weijer, A. D., Neggers, S. F. W., Diederen, K. M. J., Mandl, R. C. W., Kahn, R. S., Pol, H. E. H., & Sommer, I. E. (2011) · Human Brain Mapping · doi:10.1002/hbm.21463 · Cited by 81 · see citing works
Aberrant connectivity during self–other source monitoring in schizophrenia
Wang, L. Y., Metzak, P. D., & Woodward, T. S. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.11.012 · Cited by 80 · see citing works
Escartí, M. J., de la Iglesia-Vayá, M., Martí-Bonmatí, L., Robles, M., Carbonell, J., Lull, J. J., García-Martí, G., Manjón, J. V., Aguilar, E. J., Aleman, A., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.028 · Cited by 80 · see citing works
Self-citationCurcic-Blake, B., Liemburg, E., Vercammen, A., Swart, M., Knegtering, H., Bruggeman, R., & Aleman, A. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs107 · Cited by 78 · see citing works
Functional Brain Imaging in Schizophrenia: Selected Results and Methods
Brown, G. G., & Thompson, W. K. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_54 · Cited by 74 · cited 1× · see citing works
“Recent findings from brain imaging have revealed that auditory verbal hallucinations (AVH) in schizophrenia are associated with alterations in brain connectivity (Brown and Thompson, 2010; Jardri et al., 2011) that incorporate both functional and anatomical connections (Allen et al.”
BackgroundWhitford, T. J., Lee, S. W., Oh, J. S., de Luis-Garcia, R., Savadjiev, P., Alvarado, J. L., Westin, C.-F., Niznikiewicz, M., Nestor, P. G., McCarley, R. W., et al. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.06.003 · Cited by 74 · see citing works
Bracht, T., Horn, H., Strik, W. K., Federspiel, A., Razavi, N., Stegmayer, K., Wiest, R., Dierks, T., Müller, T., & Walther, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.01.015 · Cited by 73 · cited 1× · see citing works
“However, this study did not aim to investigate AVH per se (Bracht et al., 2014).”
BackgroundBehrendt, R. (1998) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(98)90067-0 · Cited by 72 · cited 1× · see citing works
“Another approach that focuses on perception and attentional processes is based on the idea that AVH may be caused by unbalanced mechanisms for bottom-up sensory processing on one hand and top-down mechanisms on the other hand (Behrendt, 1998; Grossberg, 2000; Aleman et al., 2003).”
BackgroundSemantic Expectations Can Induce False Perceptions in Hallucination-Prone Individuals
Vercammen, A., & Aleman, A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn063 · Cited by 72 · cited 1× · see citing works
“However, healthy controls with a propensity to AVH are more likely to report hearing a word that fits the context of a sentence when it is not actually presented (Vercammen and Aleman, 2010).”
BackgroundMcCarthy‐Jones, S., Oestreich, L., & Whitford, T. J. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.041 · Cited by 71 · cited 2× · see citing works
“The majority of large studies on chronic schizophrenia patients that incorporate both a control group and a group of patients without AVH find decreases in anatomical or functional connectivity of language areas (De Weijer et al., 2013; Oestreich et al., 2015; McCarthy-Jones et al., 2015; Cur9 ci c-Blake et al., 2013)…”
BackgroundResultThe Neuroscience of Hallucinations
Jardri, R., Cachia, A., Thomas, P., & Pins, D. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2 · Cited by 71 · see citing works
Conscious auditory perception related to long-range synchrony of gamma oscillations
Steinmann, S., Leicht, G., Ertl, M., Andreou, C., Polomac, N., Westerhausen, R., Friederici, A. D., & Mulert, C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.012 · Cited by 70 · see citing works
Steinmann, S., Leicht, G., & Mulert, C. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00055 · Cited by 68 · see citing works
Hallucinations: Synchronisation of thalamocortical γ oscillations underconstrained by sensory input
Behrendt, R. (2003) · Consciousness and Cognition · doi:10.1016/s1053-8100(03)00017-5 · Cited by 67 · see citing works
Clos, M., Diederen, K. M. J., Meijering, A. L., Sommer, I. E., & Eickhoff, S. B. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0519-5 · Cited by 67 · see citing works
Lee, K., Yoshida, T., Kubicki, M. R., Sylvain Bouix, A., Westin, C., Kindlmann, G., Niznikiewicz, M. A., Cohen, A. S., McCarley, R. W., & Shenton, M. E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.024 · Cited by 67 · see citing works
PET Imaging and Cognition in Schizophrenia
Frith, C., Friston, K. J., Liddle, P. F., & Frackowiak, R. S. J. (1992) · Journal of the Royal Society of Medicine · doi:10.1177/014107689208500414 · Cited by 66 · cited 1× · see citing works
“One approach has been to explain these impairments in terms of sensory-motor predictions from one’s own actions via forward modelling and efference copy mechanisms (Feinberg, 1978; Frith et al., 1992).”
BackgroundThe physical basis of diffusion-weighted MRI
Cercignani, M., & Horsfield, M. A. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00486-5 · Cited by 64 · cited 1× · see citing works
“FA has been proven to reflect the integrity of the axonal membrane and myelin sheet (Beaulieu, 2002), as well as the local coherence of myelinated axons (Cercignani and Horsfield, 2001).”
BackgroundKnöchel, C., O’Dwyer, L., Alves, G. S., Reinke, B., Magerkurth, J., Rotarska-Jagiela, A., Prvulovic, D., Hampel, H. J., Linden, D. E. J., & Oertel‐Knöchel, V. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.001 · Cited by 63 · cited 3× · see citing works
“Decreased FA in various parts of the cingulum has consistently been observed in schizophrenia patients (Hubl et al., 2004; Shergill et al., 2007; Knöchel et al., 2012).”
BackgroundNorthoff, G. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.3.189 · Cited by 62 · cited 5× · see citing works
“Northoff predicts that elevated resting state activity in the default mode network and auditory cortex coupled with their unaltered communication can enhance the development of AVH (Northoff, 2014; Northoff and Qin, 2011).”
BackgroundResultInfluentialEEG coherence measures during auditory hallucinations in schizophrenia
Sritharan, A., Line, P., Sergejew, A. A., Silberstein, R. B., Egan, G. F., & Copolov, D. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2005.05.010 · Cited by 62 · cited 1× · see citing works
“While they did not find significant changes in the coherence between Broca’s region and Wernicke’s area (as estimated from the scalp EEG electrode positions), the authors reported a significant increase of alpha-coherence between the left and the right superior temporal cortices during AVH (Sritharan et al., 2005).”
BackgroundWoodward, T. S., Metzak, P. D., Meier, B., & Holroyd, C. B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.049 · Cited by 60 · see citing works
Benetti, S., Pettersson-Yeo, W., Allen, P., Catani, M., Williams, S. C. R., Barsaglini, A., Kambeitz-Ilankovic, L. M., McGuire, P., & Mechelli, A. (2013) · Schizophrenia bulletin · doi:10.1093/schbul/sbt172 · Cited by 60 · cited 2× · see citing works
“Similar results were recently obtained when comparing ultra-high-risk and first-episode-psychosis individuals following AVH episodes with NoAVH subject (Benetti et al., 2015).”
ResultOpposite links of positive and negative symptomatology with memory errors in schizophrenia
Brébion, G., AMADOR, X. F., SMITH, M. J., Malaspina, D., Sharif, Z. A., & Gorman, J. M. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00076-1 · Cited by 55 · cited 1× · see citing works
“, 2010) and is specifically correlated with positive symptoms (Brebion et al., 1999).”
BackgroundAberrant resting-state connectivity in non-psychotic individuals with auditory hallucinations
Diederen, K. M. J., Neggers, S. F. W., de Weijer, A. D., van Lutterveld, R., Daalman, K., Eickhoff, S. B., Clos, M., Kahn, R. S., & Sommer, I. E. (2012) · Psychological Medicine · doi:10.1017/s0033291712002541 · Cited by 53 · cited 2× · see citing works
“Two studies found evidence for a specific role of connections between memory regions and Broca’s area (the language production area) (Sommer et al., 2012; Diederen et al., 2013) and Hoffman showed that the FC between the putamen and language areas is very important for AVH (Hoffman et al.”
BackgroundResultMechanisms of Auditory Verbal Hallucination in Schizophrenia
Cho, R., & Wu, W. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00155 · Cited by 52 · see citing works
Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia
Hoffman, R. E., Pittman, B. P., Constable, R. T., Bhagwagar, Z., & Hampson, M. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.086835 · Cited by 50 · see citing works
Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia
Abdul-Rahman, M. F., Qiu, A., Woon, P. S., Kuswanto, C. N., Collinson, S. L., & Sim, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029315 · Cited by 47 · cited 1× · see citing works
“Abdul-Rahman and colleagues specifically investigated WM abnormalities in particular loci along the AF as well as its regional lateralization in schizophrenia (Abdul-Rahman et al., 2012) by examining different WM along the whole extent of the AF.”
BackgroundAuditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia
Wigand, M. C. C., Kubicki, M. R., von Hohenberg, C. C., Leicht, G., Karch, S., Eckbo, R., Pelavin, P. E., Hawley, K. J., Rujescu, D., Sylvain Bouix, A., et al. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.948063 · Cited by 46 · cited 2× · see citing works
“, 2012), but alters during the course of the disease (Wigand et al., 2015).”
BackgroundFormal thought disorder in non-clinical individuals with auditory verbal hallucinations
Sommer, I. E., Derwort, A. M. C., Daalman, K., de Weijer, A. D., Liddle, P. F., & Boks, M. P. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.01.024 · Cited by 44 · cited 1× · see citing works
“In support of this, tangentiality and loosening of associations, types of formal thought disorder have often been reported in patients and healthy individuals with AVH (Sommer et al., 2010).”
BackgroundSurprise! A unifying model of dorsal anterior cingulate function?
Egner, T. (2011) · Nature Neuroscience · doi:10.1038/nn.2932 · Cited by 44 · see citing works
Chou, C., Marca, R. L., Steptoe, A., & Brewin, C. R. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.08.002 · Cited by 43 · see citing works
Lavigne, K. M., Rapin, L., Metzak, P. D., Whitman, J. C., Jung, K., Dohen, M., venbruck, H. L., & Woodward, T. S. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu004 · Cited by 42 · cited 2× · see citing works
“This finding could explain why AVH are such realistic experiences of speech: increased coordinated activity in this circuitry has been observed during speech perception relative to inner verbal thought (Lavigne et al., 2015).”
BackgroundMurray, E. A., Graham, K. S., & Gaffan, D. (2005) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/02724990544000077 · Cited by 41 · cited 1× · see citing works
“, 2004); the perirhinal cortex, which has a function in sensory integration, semantic and long-term memory (Murray and Richmond, 2001; Murray et al., 2005).”
BackgroundAuditory hallucinations: Expectation–perception model
Nazimek, J. M., Hunter, M. D., & Woodruff, P. W. R. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.03.014 · Cited by 41 · cited 1× · see citing works
“suggested that AVHs arise from attenuated prediction error processing (Nazimek et al., 2012).”
BackgroundEliades, S. J., & Wang, X. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00698.2012 · Cited by 41 · see citing works
Involuntary Cognitions in Everyday Life: Exploration of Type, Quality, Content, and Function
Krans, J., de Bree, J., & Moulds, M. L. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00007 · Cited by 37 · cited 1× · see citing works
“Indeed, patients often mention their hallucinations occurring most frequently at times when focused attention is low, at the beginning and end of the day (Krans et al., 2015; Nayani and David, 1996).”
BackgroundFridberg, D. J., Brenner, A., & Lysaker, P. H. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.06.026 · Cited by 36 · cited 1× · see citing works
“This is well documented in the study of schizophrenia (Fridberg et al., 2010) and is specifically correlated with positive symptoms (Brebion et al.”
BackgroundKoenig, T. W., van Swam, C., Dierks, T., & Hubl, D. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.07.016 · Cited by 35 · see citing works
Oestreich, L., McCarthy‐Jones, S., & Whitford, T. J. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9421-5 · Cited by 33 · cited 3× · see citing works
“The majority of large studies on chronic schizophrenia patients that incorporate both a control group and a group of patients without AVH find decreases in anatomical or functional connectivity of language areas (De Weijer et al., 2013; Oestreich et al., 2015; McCarthy-Jones et al., 2015; Cur9 ci c-Blake et al., 2013)…”
BackgroundMethodLocating voices in space: A perceptual model for auditory hallucinations?
Hunter, M. D. (2004) · Cognitive Neuropsychiatry · doi:10.1080/13546800344000174 · Cited by 32 · see citing works
Functional brain networks involved in reality monitoring
Metzak, P. D., Lavigne, K. M., & Woodward, T. S. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.05.014 · Cited by 30 · cited 18× · see citing works
“2), ACC, and insula (Mesulam, 1990).”
BackgroundInfluentialKoutsoukos, E., Angelopoulos, E. K., Maillis, A., Papadimitriou, G. N., & Stefanis, C. N. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.12.005 · Cited by 30 · cited 1× · see citing works
“The average differences of theta-gamma-coupling between hallucinatory and resting stages were significant in the left temporal area (Koutsoukos et al., 2013).”
BackgroundGriškova-Bulanova, I., Hubl, D., van Swam, C., Dierks, T., & Koenig, T. W. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.02.009 · Cited by 29 · see citing works
Blom, J. D., & Sommer, I. E. (2010) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e3181b2791e · Cited by 28 · cited 2× · see citing works
“, command hallucinations, third-person hallucinations, and thought echo (Blom and Sommer, 2010; McCarthy-Jones et al., 2014).”
BackgroundHallucinatory Experiences in Non-clinical Populations
Hill, K., & Linden, D. E. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_2 · Cited by 26 · cited 1× · see citing works
“1 of this paper) and emotional processing, added to the negative emotional connotation of AVH in patients with schizophrenia (Hill and Linden, 2013), demands further investigation of the memory/limbic network.”
BackgroundCortical Interactions During the Experience of Auditory Verbal Hallucinations
Angelopoulos, E. K., Koutsoukos, E., Maillis, A., Papadimitriou, G. N., & Stefanis, C. N. (2011) · Journal of Neuropsychiatry · doi:10.1176/jnp.23.3.jnp287 · Cited by 26 · see citing works
de la Iglesia-Vayá, M., Escartí, M. J., Molina‐Mateo, J., Martí‐Bonmatí, L., Gadea, M., Castellanos, F. X., Aguilar, E. J., Robles, M., Biswal, B. B., & Sanjuán, J. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.08.027 · Cited by 26 · see citing works
Thoma, R., Chaze, C., Lewine, J., Calhoun, V., Clark, V., Bustillo, J., Houck, J., Ford, J., Bigelow, R., Wilhelmi, C., et al. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00039 · Cited by 26 · see citing works
On the definition and interpretation of voice selective activation in the temporal cortex
Bethmann, A., & Brechmann, A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00499 · Cited by 25 · cited 1× · see citing works
“The best such example is the superior temporal area where the secondary auditory cortex overlaps with Wernicke’s area (Bethmann and Brechmann, 2014).”
BackgroundInsights into hallucinations in schizophrenia: Novel treatment approaches
Aleman, A., & Larøi, F. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.90 · Cited by 24 · cited 1× · see citing works
“Further studies should be directed towards discerning which of the four abovementioned scenarios (Ford and Hoffman, 2013a; Aleman and Larøi, 2011; Waters et al., 2012; Northoff, 2014) is most plausible by adopting a more specific experimental paradigm and using causal inference analysis methods.”
BackgroundVoice recognition and altered connectivity in schizophrenic patients with auditory hallucinations
Mou, X., Bai, F., Xie, C., Shi, J., Yao, Z., Hao, G.-F., Chen, N., & Zhang, Z. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.03.006 · Cited by 21 · see citing works
Henshall, K. R., Sergejew, A. A., Rance, G., McKay, C. M., & Copolov, D. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.05.005 · Cited by 20 · see citing works
Structural changes of the corpus callosum in tinnitus
Diesch, E. (2012) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2012.00017 · Cited by 19 · cited 2× · see citing works
“This might explain why a relationship between interhemispheric auditory connectivity and auditory phantom perception is found not only in the context of AVH in schizophrenia, but also for example in the context of tinnitus (Diesch et al., 2012).”
BackgroundFord, J. M., & Hoffman, R. E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_19 · Cited by 17 · see citing works
Thought echo reflects the activity of the phonological loop
David, A. S. (1994) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1994.tb01098.x · Cited by 17 · cited 1× · see citing works
“Similar concepts have been put forward as the breakaway speech and unbidden thoughts account of AVH (David, 1994; Ford and Hoffman, 2013b; Hoffman, 2010).”
BackgroundRevisiting Arieti's "Listening Attitude" and Hallucinated Voices
Hoffman, R. E. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq025 · Cited by 17 · cited 1× · see citing works
“Similar concepts have been put forward as the breakaway speech and unbidden thoughts account of AVH (David, 1994; Ford and Hoffman, 2013b; Hoffman, 2010).”
BackgroundA white matter tract mediating awareness of speech
Koubeissi, M. Z., Vaca, G. F., Maciunas, R. J., & Stephani, C. (2015) · Neurology · doi:10.1212/wnl.0000000000002246 · Cited by 14 · see citing works
Henshall, K. R., Sergejew, A. A., McKay, C. M., Rance, G., Shea, T. L., Hayden, M. J., Innes-Brown, H., & Copolov, D. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.01.020 · Cited by 12 · cited 1× · see citing works
“This finding can be attributed to transcallosal dysfunction in patients with AH (Henshall et al., 2012).”
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Jones (1999) · doi:10.1002/(sici)1522-2594(199907)42:1
Lepage (1998) · doi:10.1002/(sici)1098-1063(1998)8:4
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- Mulert C. Kirsch V. Whitford T.J. Alvarado J. Pelavin P. McCarley R.W. Kubicki M. Salisbury D.F. Shenton M.E. Hearing voices: a role of interhemispheric auditory connectivity? World J. Biol. Psychiatry 13 2012 153 158 21623667 PMC5768313
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Li, S., Hu, N., Zhang, W., Bo, T., Dai, J., Gong, Y., Tan, Y., Cai, D., & Lui, S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00482 · Cited by 208 · see citing works
Network Localization of State and Trait of Auditory Verbal Hallucinations in Schizophrenia
Mo, F., Zhao, H., Li, Y., Cai, H., Song, Y., Wang, R., Yu, Y., & Zhu, J. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae020 · Cited by 135 · see citing works
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Lesions causing hallucinations localize to one common brain network
Kim, N. Y., Hsu, J., Talmasov, D., Joutsa, J., Soussand, L., Wu, O., Rost, N. S., Morenas‐Rodríguez, E., Martí‐Fábregas, J., Pascual‐Leone, Á., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0565-3 · Cited by 117 · see citing works
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Evolutionary modifications in human brain connectivity associated with schizophrenia
van den Heuvel, M. P., Scholtens, L. H., de Lange, S. C., Pijnenburg, R., Cahn, W., van Haren, N. E. M., Sommer, I. E., Bozzali, M., Koch, K., Boks, M. P., et al. (2019) · Brain · doi:10.1093/brain/awz330 · Cited by 82 · see citing works
Understanding visual hallucinations: A new synthesis
Collerton, D., Barnes, J., Diederich, N. J., Dudley, R., ffytche, D., Friston, K., Goetz, C. G., Goldman, J. G., Jardri, R., Kulisevsky, J., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105208 · Cited by 83 · see citing works
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Auditory Verbal Hallucinations in Schizophrenia From a Levels of Explanation Perspective.
Hugdahl, K., & Sommer, I. (2018) · Schizophrenia bulletin · doi:10.1093/schbul/sbx142 · Cited by 83 · see citing works
Kantrowitz, J. T., Sehatpour, P., Avissar, M., Horga, G., Gwak, A., Hoptman, M. J., Beggel, O., Girgis, R. R., Vail, B., Silipo, G. S., et al. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.03.003 · Cited by 66 · see citing works
Barber, L., Reniers, R., & Upthegrove, R. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01670-7 · Cited by 49 · see citing works
“[9] found that the FA of white matter tracts was generally increased in participants with acute psychosis but decreased in those with chronic psychosis.”
BackgroundInfluentialGuttesen, L. L., Albert, N., Nordentoft, M., & Hjorthøj, C. R. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.09.001 · Cited by 59 · see citing works
Brain connectivity alterations in early psychosis: from clinical to neuroimaging staging
Griffa, A., Baumann, P., Klauser, P., Mullier, E., Cleusix, M., Jenni, R., van den Heuvel, M. P., Kim, Q., Conus, P., & Hagmann, P. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0392-y · Cited by 51 · see citing works
Dynamic Functional Connectivity Patterns in Schizophrenia and the Relationship With Hallucinations
Weber, S., Johnsen, E., Kroken, R. A., Løberg, E., Kandilarova, S., Stoyanov, D., Kompus, K., & Hugdahl, K. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00227 · Cited by 54 · see citing works
Homotopic functional connectivity disruptions in schizophrenia and their associated gene expression
Cai, M., Ji, Y., Zhao, Q., Xue, H., Sun, Z., Wang, H., Zhang, Y., Chen, Y., Zhao, Y., Zhang, Y., et al. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120551 · Cited by 45 · see citing works
Duggento, A., Passamonti, L., Valenza, G., Barbieri, R., Guerrisi, M., & Toschi, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-23996-x · Cited by 45 · see citing works
Rollins, C. P. E., Garrison, J., Simons, J., Rowe, J., O'Callaghan, C., Murray, G., & Suckling, J. (2018) · bioRxiv · doi:10.1016/j.eclinm.2019.01.012 · Cited by 39 · see citing works
“Obtaining differentiating evidence is difficult as these models are not mutually exclusive, each drawing upon a similar repertoire of constituents, making it non-trivial to derive corresponding predictions [42].”
BackgroundI am Me: Brain systems integrate and segregate to establish a multidimensional sense of self
Plinio, S. D., Perrucci, M. G., Aleman, A., & Ebisch, S. J. H. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116284 · Cited by 44 · see citing works
Pérez-Rando, M., Elvira, U. K., García‐Martí, G., Gadea, M., Aguilar, E. J., Escartí, M. J., Ahulló-Fuster, M.-A., Grasa, E., Corripio, I., Sanjuán, J., et al. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103070 · Cited by 43 · see citing works
“These nuclei establish sparse connections with the auditory cortex, as shown by tracer studies performed in primates (de la Mothe et al., 2012; Scott et al., 2017), and they receive inputs from Broca’s area, indicating an involvement in language processing (Goldman-Rakic and Porrino, 1985).”
BackgroundAllen, P., Sommer, I. E., Jardri, R., Eysenck, M. W., & Hugdahl, K. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.02.004 · Cited by 41 · see citing works
“Functional connectivity between Wernicke’s area and Broca’s areas, for example, is disrupted during inner-speech processing in schizophrenia patients who hear voices (Curcic-Blake et al., 2017).”
The interhemispheric miscommunication theory of auditory verbal hallucinations in schizophrenia
Steinmann, S., Leicht, G., & Mulert, C. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.02.002 · Cited by 44 · see citing works
Kubera, K., Rashidi, M., Schmitgen, M., Barth, A., Hirjak, D., Sambataro, F., Calhoun, V., & Wolf, R. C. (2019) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.03.007 · Cited by 42 · see citing works
Dauwan, M., Linszen, M. M. J., Lemstra, A. W., Scheltens, P., Stam, C. J., & Sommer, I. E. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.013 · Cited by 37 · see citing works
Zhang, Z., Zhuo, K., Xiang, Q., Sun, Y. M., Suckling, J., Wang, J., Liu, D., & Sun, Y. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01398-4 · Cited by 40 · see citing works
Alamian, G., Hincapié, A.-S., Pascarella, A., Thiery, T., Combrisson, E., Saive, A.-L., Martel, V., Altukhov, D., Haesebaert, F., & Jerbi, K. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.06.246 · Cited by 38 · see citing works
Toward personalized treatment of hallucinations
Sommer, I. E., Kleijer, H., & Hugdahl, K. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000416 · Cited by 39 · see citing works
Auditory Hallucinations as Translational Psychiatry: Evidence from Magnetic Resonance Imaging
Hugdahl, K. (2017) · Balkan Medical Journal · doi:10.4274/balkanmedj.2017.1226 · Cited by 30 · see citing works
“Finally, with regard to the paradoxical finding of competition between inner and outer voices, I think that this was nicely summarized by (21) in their recent review of imaging studies of auditory hallucinations.”
BackgroundResultZhang, X., Gao, J., Zhu, F., Wang, W., Fan, Y., Ma, Q., Ma, X., & Yang, J. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.01.002 · Cited by 34 · see citing works
Emerging Temporal Lobe Dysfunction in People at Clinical High Risk for Psychosis
Allen, P., Moore, H. M., Corcoran, C. M., Gilleen, J., Kozhuharova, P., Reichenberg, A., & Malaspina, D. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00298 · Cited by 35 · see citing works
“(87) for review] and auditory verbal hallucinations (10, 84, 85).”
BackgroundEffects of age and sex on clinical high-risk for psychosis in the community
Schultze-Lutter, F., Schimmelmann, B. G., Flückiger, R., & Michel, C. (2020) · World Journal of Psychiatry · doi:10.5498/wjp.v10.i5.101 · Cited by 34 · see citing works
Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia
Takahashi, T., Goto, T., Nobukawa, S., Tanaka, Y., Kikuchi, M., Higashima, M., & Wada, Y. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.11.004 · Cited by 34 · see citing works
Intrinsic 40Hz-phase asymmetries predict tACS effects during conscious auditory perception
Meier, J., Nolte, G., Schneider, T. R., Engel, A. K., Leicht, G., & Mulert, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213996 · Cited by 31 · see citing works
Lavigne, K. M., & Woodward, T. S. (2017) · Human Brain Mapping · doi:10.1002/hbm.23934 · Cited by 32 · see citing works
“…patients at rest (Alderson-Day et al., 2016; Shinn, Baker, Cohen, & €Ong€ur, 2013); however, findings of task-based trait studies are less consistent (Ćurčić-Blake et al., 2017), with some reporting hypoactivity (Kompus, Westerhausen, 1A clear distinction between coordinated hyperactivity and…”
BackgroundMethodResultInfluentialThiebes, S., Steinmann, S., Ćurić, S., Polomac, N., Andreou, C., Eichler, I.-C., Eichler, L., Zöllner, C., Gallinat, J., Leicht, G., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0014-z · Cited by 32 · see citing works
Shinn, A. K., Wolff, J. D., Hwang, M., Lebois, L. A. M., Robinson, M. A., Winternitz, S. R., Öngür, D., Ressler, K. J., & Kaufman, M. L. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01011 · Cited by 31 · see citing works
Hjelmervik, H., Craven, A., Sinceviciute, I., Johnsen, E., Kompus, K., Bless, J., Kroken, R., Løberg, E., Ersland, L., Grüner, R., et al. (2019) · Schizophrenia bulletin · doi:10.1093/schbul/sbz099 · Cited by 33 · see citing works
Modality-general and modality-specific processes in hallucinations
Fernyhough, C. (2019) · Psychological Medicine · doi:10.1017/s0033291719002496 · Cited by 27 · see citing works
Sasabayashi, D., Takahashi, T., Takayanagi, Y., Nemoto, K., Ueno, M., Furuichi, A., Higuchi, Y., Mizukami, Y., Kobayashi, H., Yuasa, Y., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad131 · Cited by 32 · see citing works
Abnormal dynamic resting-state brain network organization in auditory verbal hallucination
Geng, H., Xu, P., Sommer, I. E., Luo, Y., Aleman, A., & Ćurĉić‐Blake, B. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02119-1 · Cited by 27 · see citing works
Decoding Activity in Broca's Area Predicts the Occurrence of Auditory Hallucinations Across Subjects
Fovet, T., Yger, P., Lopes, R., de Pierrefeu, A., Duchesnay, É., Houenou, J., Thomas, P., Szaffarczyk, S., Domenech, P., & Jardri, R. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.08.024 · Cited by 28 · see citing works
Steinmann, S., Amselberg, R., Cheng, B., Thomalla, G., Engel, A. K., Leicht, G., & Mulert, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-33586-6 · Cited by 28 · see citing works
Gimenez, U., Boulan, B., Mauconduit, F., Taurel, F., Leclercq, M., Denarier, É., Brocard, J., Gory‐Fauré, S., Andrieux, A., Lahrech, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10544-2 · Cited by 27 · see citing works
Scott, M. R., & Meador‐Woodruff, J. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0359-7 · Cited by 27 · see citing works
Brain‐based ranking of cognitive domains to predict schizophrenia
Karrer, T. M., Bassett, D. S., Derntl, B., Gruber, O., Aleman, A., Jardri, R., Laird, A. R., Fox, P. T., Eickhoff, S. B., Grisel, O., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24716 · Cited by 25 · see citing works
fMRI capture of auditory hallucinations: Validation of the two‐steps method
Leroy, A., Foucher, J., Pins, D., Delmaire, C., Thomas, P., Roser, M. M., Lefebvre, S., Amad, A., Fovet, T., Jaafari, N., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23707 · Cited by 25 · see citing works
“Again, the consideration that hallucinations may result from neural dysconnectivity (e.g., Ćurčić-Blake et al., 2017) favors ICA over more conventional activation-based approaches, such as GLM.”
de Pierrefeu, A., Fovet, T., Hadj‐Selem, F., Löfstedt, T., Ciuciu, P., Lefebvre, S., Thomas, P., Lopes, R., Jardri, R., & Duchesnay, É. (2018) · Human Brain Mapping · doi:10.1002/hbm.23953 · Cited by 25 · see citing works
Jaroszynski, C., Amorim-Leite, R., Deman, P., Perrone‐Bertolotti, M., Chabert, F., Job-Chapron, A.-S., Minotti, L., Hoffmann, D., Olivier David, A., & Kahane, P. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.08.002 · Cited by 25 · see citing works
Language-Related Neurophysiological Deficits in Schizophrenia
Hirano, S., Spencer, K., Onitsuka, T., & Hirano, Y. (2019) · Clinical EEG and Neuroscience · doi:10.1177/1550059419886686 · Cited by 26 · see citing works
Hugdahl, K., Craven, A. R., Johnsen, E., Ersland, L., Stoyanov, D., Kandilarova, S., Sandøy, L. B., Kroken, R. A., Løberg, E., & Sommer, I. E. (2022) · Schizophrenia Bulletin · doi:10.1093/schbul/sbac028 · Cited by 26 · see citing works
Cognitive neurophysiology of the prefrontal cortex
Helfrich, R. F., & Knight, R. T. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804281-6.00003-3 · Cited by 22 · see citing works
Xie, S., Liu, B., Wang, J., Zhou, Y., Cui, Y. J., Song, M., Chen, Y., Li, P., Lü, L., Lv, L., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.12.024 · Cited by 23 · see citing works
Recent findings on neurofeedback training for auditory hallucinations in schizophrenia
Hirano, Y., & Tamura, S. (2021) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000693 · Cited by 18 · see citing works
“self-monitoring hypothesis, reduced sense of control, executive and inhibitory control, unstable memories, source monitoring hypothesis, interhemispheric miscommunication, top-down effect and bottom-up prediction deficits, and a hybrid model of spontaneous activations and self-monitoring deficits) in schizophrenia [7,…”
BackgroundShi, K., Pang, X., Wang, Y., Li, C., Long, Q., & Zheng, J. (2021) · Neuroradiology · doi:10.1007/s00234-021-02706-x · Cited by 23 · see citing works
Auditory verbal hallucination and the auditory network: From molecules to connectivity
Huang, J., Zhuo, C., Xu, Y. J., & Lin, X. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.051 · Cited by 21 · see citing works
Wei, Y., Han, S., Chen, J., Wang, C., Wang, W., Li, H., Song, X., Xue, K., Zhang, Y., & Cheng, J. (2022) · Human Brain Mapping · doi:10.1002/hbm.25958 · Cited by 20 · see citing works
Jonak, K., Krukow, P., Jonak, K. E., Grochowski, C., & Karakuła‐Juchnowicz, H. (2018) · Clinical EEG and Neuroscience · doi:10.1177/1550059418807372 · Cited by 20 · see citing works
“These and subsequent studies4 gave way to a disconnection hypothesis of psychotic disorders, which formed the basis for a model of aberrant modulation of synaptic efficacy.5,6 According to this hypothesis, patients with SZ have an impaired functional and structural connections between brain structures, hence it is pos…”
BackgroundRössler, J., Unterassner, L., Wyss, T., Haker, H., Brugger, P., Rössler, W., & Wotruba, D. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sby079 · Cited by 20 · see citing works
Auditory Hallucinations: Does a Continuum of Severity Entail Continuity in Mechanism?
Waters, F., & Fernyhough, C. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz002 · Cited by 20 · see citing works
Mondino, M., Fonteneau, C., Simon, L., Dondé, C., Haesebaert, F., Poulet, E., & Brunelin, J. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01149-4 · Cited by 19 · see citing works
Default mode network alterations underlie auditory verbal hallucinations in schizophrenia
Marino, M., Spironelli, C., Mantini, D., Craven, A. R., Ersland, L., Angrilli, A., & Hugdahl, K. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.08.006 · Cited by 21 · see citing works
Humpston, C. S., & Woodward, T. S. (2024) · The Lancet Psychiatry · doi:10.1016/s2215-0366(24)00061-0 · Cited by 19 · see citing works
Zhuo, C., Xiao, B., Ji, F., Lin, X., Jiang, D., Tian, H., Xu, Y. J., Wang, W., & Chen, C. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00351-1 · Cited by 19 · see citing works
Frajman, A., Maggio, N., Muler, I., Haroutunian, V., Katsel, P., Yitzhaky, A., Weiser, M., & Hertzberg, L. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.04.027 · Cited by 15 · see citing works
Visual Hallucinations in Psychosis: The Curious Absence of the Primary Visual Cortex
van Ommen, M. M., van Laar, T., Renken, R. J., Cornelissen, F. W., & Bruggeman, R. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbac140 · Cited by 18 · see citing works
Dixon, B. J., Kumar, J., & Danielmeier, C. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.010 · Cited by 18 · see citing works
Do patients with hallucinations imagine speech right?
Altamura, M., Prete, G., Elia, A., Angelini, E., Padalino, F. A., Bellomo, A., Tommasi, L., & Fairfield, B. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107567 · Cited by 17 · see citing works
Curtis, M. T., Coffman, B. A., & Salisbury, D. F. (2020) · Human Brain Mapping · doi:10.1002/hbm.25256 · Cited by 16 · see citing works
Zhuo, C., Fang, T., Chen, C., Chen, M., Sun, Y., Ma, X., Li, R., Tian, H., & Ping, J. (2020) · Brain and Behavior · doi:10.1002/brb3.1991 · Cited by 17 · see citing works
“…brain include important areas of the executive control network, attention network, memory network, and emotional network, and default mode network (Alderson-Day et al., 2015; Ćurčić-Blake et al., 2017; Hugdahl, 2017), damaged GM is often associated with the first-episode and chronic schizophrenia.”
BackgroundMartin, A. M. S., Bartolomeo, L. A., Howell, J. M., Hetrick, W. P., Bolbecker, A. R., Breier, A. F., Kidd, G. R., & O’Donnell, B. F. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0839-1 · Cited by 17 · see citing works
“These heterogeneous results may reflect the variety of neurobiological mechanisms and responses to treatment which modulate the experience of hallucinations [13, 30].”
Patient, interrupted: MEG oscillation dynamics reveal temporal dysconnectivity in schizophrenia
Alamian, G., Pascarella, A., Lajnef, T., Knight, L., Walters, J., Singh, K. D., & Jerbi, K. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102485 · Cited by 16 · see citing works
“, 1994; Uhlhaas and Singer, 2010) have probed structural and functional alterations among schizophrenia patients and have found significant and consistent differences in terms of the physical properties and connectivity patterns of their neural signal compared to controls (multimodal reviews: Alamian et al., 2017; Ćur…”
Richards, S., Hughes, M., Woodward, T., Rossell, S., & Carruthers, S. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.006 · Cited by 14 · see citing works
Cheng Ann, C. H. E. N., Huang, H., Qin, X., Zhang, L., Rong, B., Wang, G., & Wang, H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.956895 · Cited by 16 · see citing works
Zhuo, C., Zhou, C., Lin, X., Tian, H., Wang, L., Chen, C., Ji, F., Xu, Y. J., & Jian, D. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109738 · Cited by 16 · see citing works
Weber, S., Hjelmervik, H., Craven, A., Johnsen, E., Kroken, R., Løberg, E., Ersland, L., Kompus, K., & Hugdahl, K. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.643564 · Cited by 17 · see citing works
“Based on findings of impaired cognitive control in patients with AVH during an auditory task (33) as well as abnormal connectivity between the ACC and the STG (2), it has been suggested that AVH arise from impaired top-down control of prefrontal areas over bottom-up processes in auditory areas (2, 22, 29).”
BackgroundSun, Q., Fang, Y., Shi, Y., Wang, L., Peng, X., & Tan, L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.544746 · Cited by 16 · see citing works
Liang, N., Liu, S., Li, X.-R., Wen, D., Li, Q.-Q., Tong, Y., & Xu, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.865738 · Cited by 15 · see citing works
Gill, K., Percival, C. M., Roes, M., Arreaza, L., Chinchani, A. M., Sanford, N., Sena, W., Mohammadsadeghi, H., Menon, M., Hughes, M. E., et al. (2022) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgac050 · Cited by 19 · see citing works
“Component 3 is characterized by bilateral deactivation in occipital areas such as the occipital pole (xyz: −27, −91, 16; 15, −88, 28).”
BackgroundGao, J., Zhang, D.-S., Wang, L., Wang, W., Fan, Y.-J., Tang, M., Zhang, X., Lei, X.-Y., Wang, Y.-R., Yang, J., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00575 · Cited by 16 · see citing works
“In previous models including the “memory intrusion”, “selfmonitoring”, “two hit bottom-up and top-down”, and hybrid models, language, auditory, and memory brain networks were closely associated with AVH in patients with schizophrenia (4).”
BackgroundOkuneye, V. T., Meda, S., Pearlson, G., Clementz, B., Keshavan, M., Tamminga, C., Ivleva, E., Sweeney, J., Gershon, E., & Keedy, S. (2020) · NeuroImage: Clinical · doi:10.1016/j.nicl.2020.102358 · Cited by 14 · see citing works
“The models include hypersensitivity or activation of auditory cortex including primary and association auditory cortex, and/or adjacent polymodal association cortex of the inferior parietal lobe, dysregulation of receptive auditory cortex by disrupted top-down influences especially from frontal speech areas, altered i…”
Strawson, W., Wang, H.-T., Quadt, L., Sherman, M., Larsson, D., Davies, G., Mckeown, B., Silva, M., Fielding-Smith, S. F., Jones, A.-M., et al. (2021) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab093 · Cited by 12 · see citing works
“Symptom-capture studies of AVH echo the involvement of temporal language regions: meta-analyses support greater activation in STG and adjacent temporo-parietal language regions during AVH experience in patients with schizophrenia (Ćurčić-Blake et al., 2017).”
BackgroundMethodUncovering hidden resting state dynamics: A new perspective on auditory verbal hallucinations
Honcamp, H., Schwartze, M., Linden, D. E. J., El‐Deredy, W., & Kotz, S. A. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119188 · Cited by 12 · see citing works
“The altered FC between IFG and parahippocampal regions in non-clinical voice-hearers might facilitate memory retrieval, thereby providing additional evidence for the hypothesized intrusion of long-term memory into ongoing cognitive processes (Ćurčić-Blake et al., 2017; Diederen et al., 2012).”
BackgroundAn integrative perspective on the role of touch in the development of intersubjectivity
Plinio, S. D., Scalabrini, A., & Ebisch, S. J. H. (2022) · Brain and Cognition · doi:10.1016/j.bandc.2022.105915 · Cited by 13 · see citing works
Draining the pond and catching the fish: Uncovering the ecosystem of auditory verbal hallucinations
Looijestijn, J., Blom, J. D., Hoek, H. W., Renken, R. J., Liemburg, E. J., Sommer, I. E., Aleman, A., & Goekoop, R. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.09.016 · Cited by 13 · see citing works
Zhuo, C., Li, G., Ji, F., Chen, C., Jiang, D., Lin, X., Xu, Y. J., Tian, H., Wang, L., Zhou, C., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00210-8 · Cited by 13 · see citing works
“In recent years, based on studies of AVH and NVAH in patients with schizophrenia, many researchers have proposed that AVH are caused by disturbances in brain circuits and networks (Curcic-Blake et al. 2017).”
BackgroundChen, Y., Guo, Z., Wang, Y., Yin, H., Zhang, S., & Liu, W. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1102927 · Cited by 12 · see citing works
“The STG processes auditory signals from the primary auditory cortex and then via the thalamus sends them to higher-order areas and other language areas (33).”
BackgroundInteractive mapping of language and memory with the GE2REC protocol
Banjac, S., Roger, É., Cousin, É., Perrone‐Bertolotti, M., Haldin, C., Pichat, C., Lamalle, L., Minotti, L., Kahane, P., & Baciu, M. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00355-x · Cited by 12 · see citing works
“Furthermore, there are disorders such as post-stroke aphasia (Schuchard and Thompson 2014) or conditions that cause auditory hallucinations ( Ć ur č i ć -Blake et al. 2017) in which language regions are impaired, but the symptoms also manifest in the memory domain.”
BackgroundHe, J., Ren, H., Li, J., Dong, M., Dai, L., Li, Z., Miao, Y., Li, Y., Tan, P., Gu, L., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.831714 · Cited by 12 · see citing works
Altered language network lateralization in euthymic bipolar patients: a pilot study
Romeo, Z., Marino, M., Angrilli, A., Semenzato, I., Favaro, A., Magnolfi, G., Padovan, G. B., Mantini, D., & Spironelli, C. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02202-7 · Cited by 12 · see citing works
“At the same time, past findings suggested that AVH are associated with increased connectivity among inferior frontal gyrus, Wernicke’s area, and striatal brain regions, also distributed to right hemisphere homologs [72].”
BackgroundRieger, K., Rarra, M.-H., Hernandez, L. D., Hubl, D., & Koenig, T. W. (2018) · Clinical EEG and Neuroscience · doi:10.1177/1550059418765810 · Cited by 12 · see citing works
“6 In the first pre-session (1), patients were fully informed about the experimental procedure and inclusion and exclusion criteria were evaluated.”
MethodFalkenberg, L. E., Westerhausen, R., Johnsen, E., Kroken, R., Løberg, E., Bereśniewicz, J., Kazimierczak, K., Kompus, K., Ersland, L., Sandøy, L. B., et al. (2020) · Psychiatry research. Neuroimaging · doi:10.1016/j.pscychresns.2020.111088 · Cited by 11 · see citing works
Hwang, M., Roh, Y. S., Talero, J., Cohen, B. M., Baker, J. T., Brady, R. O., Öngür, D., & Shinn, A. K. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102893 · Cited by 12 · see citing works
Zhuo, C., Ji, F., Lin, X. J., Tian, H., Wang, L., Xu, Y. J., Wang, W., Zhong, B., & Lin, X. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01102-5 · Cited by 11 · see citing works
“In summary, our findings of this pilot study are more inclined to support the “imbalance in top-down/bottom-up influences” hypothesis of AVH [35, 41, 43, 45].”
BackgroundResultInfluentialFrancis, A. M., Knott, V., Labelle, A., & Fisher, D. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.540738 · Cited by 11 · see citing works
“It has been previously shown that AHs are reduced when external speech is present (20–22), with a corresponding deactivation of auditory cortex suggesting generalized cortical hypofunction due to sensory overload when AHs compete with external auditory stimulation (98, 99).”
BackgroundCircular inference predicts nonuniform overactivation and dysconnectivity in brain-wide connectomes
Bouttier, V., Duttagupta, S., Denève, S., & Jardri, R. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2020.12.045 · Cited by 11 · see citing works
Sato, Y., Sakuma, A., Ohmuro, N., Katsura, M., Abe, K., Tomimoto, K., Iizuka, K., Ito, F., Tomita, H., & Matsumoto, K. (2021) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgab015 · Cited by 9 · see citing works
Zhuo, C., Tian, H., Fang, T., Li, R., Li, Y., Kong, L., Cai, Z., Zheng, L., Lin, X., & Chen, C. (2020) · Europe PMC (PubMed Central) · Cited by 9 · see citing works
Bereśniewicz, J., Craven, A., Hugdahl, K., Løberg, E., Kroken, R., Johnsen, E., & Grüner, R. (2021) · Diagnostics · doi:10.3390/diagnostics11010139 · Cited by 8 · see citing works
“Several studies suggest that the left arcuate fasciculus, which is the critical pathway of the language network, show reduced FA-values in AVH+ patients [6,17,61,62].”
BackgroundResultAubonnet, R., Banea, O. C., Sirica, R., Wassermann, E. M., Yassine, S., Jacob, D., Magnúsdóttir, B. B., Haraldsson, M. H., Stefánsson, S. B., Jónasson, V. D., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.575538 · Cited by 9 · see citing works
Hu, J.-H., Xǔ, J., Shang, S., Chen, H., Yin, X., Qi, J., & Wu, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.752419 · Cited by 10 · see citing works
- Authors
- Ćurčić-Blake, B., Ford, J. M., Hubl, D., Orlov, N. D., Sommer, I. E., Waters, F., Allen, P., Jardri, R., Woodruff, P. W., David, O., Mulert, C., Woodward, T. S., & Aleman, A.
- Affiliations
- San Francisco VA Medical Center (US)
- University of Bern (CH)
- King's College London (GB)
- University Medical Center Utrecht (NL)
- The University of Western Australia (AU)
- Centre National de la Recherche Scientifique (FR)
- University of Sheffield (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- University of British Columbia (CA)
- University Medical Center Groningen (NL)
- ORCID
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 148
- Pages
- 1-20
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC5240789
- OpenAlex
- W2552561399
- Cited by
- 224
- References
- 200
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 20 · 2023: 18 · 2022: 21 · 2021: 28 · 2020: 34 · 2019: 35 · 2018: 20 · 2017: 13 · 2016: 1
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc-nd)
- HAL (submittedVersion, cc-by-nc-nd)
- UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by-nc-nd)
- BORIS (University Library Bern) (submittedVersion, cc-by-nc-nd)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- LillOA (Université de Lille (University Of Lille)) (submittedVersion, cc-by-nc-nd)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-nd)
- Open Access CRIS of the University of Bern
- Funders
- NWO VICI (453-11-004)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- auditory verbal hallucinations, language network, auditory network, functional connectivity, structural connectivity, symptom association, interhemispheric connectivity, striatum, source monitoring, top-down attention, psychosis, first-episode psychosis, chronic psychosis, fronto-temporal connectivity
- MeSH terms
- Auditory Perception, Hallucinations, Humans, Language, Memory, Nerve Net
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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