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Cited by 33Attention Deficit Hyperactivity DisorderAdvanced Neuroimaging Techniques and ApplicationsAutism Spectrum Disorder Research

ADHD severity is associated with white matter microstructure in the subgenual cingulum

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Cooper, Miriam, Thapar, Anita, Jones, Derek K.·2015·NeuroImage: Clinical
DOI 10.1016/j.nicl.2015.02.012PMC PMC4375644
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Abstract

AIMS: This analysis examined hypothesised associations between microstructural attributes in specific white matter (WM) tracts selected a priori and measures of clinical variability in adolescents with a diagnosis of attention deficit hyperactivity disorder (ADHD). Firstly, associations were explored between WM microstructure and ADHD severity in the subgenual cingulum. Secondly, to ensure that tract-specific approaches afforded enhanced rather than differential sensitivity, associations were measured between WM microstructure and autistic traits in the right corticospinal tract based on results of a previously-published voxelwise analysis. METHODS: 40 right-handed males aged 14-18 years (19 with DSM-IV combined type ADHD and 21 healthy controls) underwent a 60 direction diffusion MRI scan. Clinical ADHD and autism variation were assessed by validated questionnaires. Deterministic tractography based on spherical deconvolution methods was used to map the subgenual cingulum and corticospinal tract. RESULTS: Fractional anisotropy was positively correlated and radial diffusivity was negatively correlated with a) ADHD severity in the left subgenual cingulum and b) autistic traits in the inferior segment of the right corticospinal tract. No case-control differences were found. CONCLUSIONS: Results shed light on possible anatomical correlates of ADHD severity and autistic symptoms in pathways which may be involved in the ADHD phenotype. They provide further evidence that tract-specific approaches may a) reveal associations between microstructural metrics and indices of phenotypic variability which would not be detected using voxelwise approaches, and b) provide improved rather than differential sensitivity compared to voxelwise approaches.

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  • In 19 adolescents with ADHD, ADHD severity correlated with increased FA and reduced radial diffusivity.

    “ADHD severity correlated with increased FA and reduced radial diffusivity (Cooper et al., 2015).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Cooper et al., 2015

    The Results report that greater ADHD severity was significantly associated with higher FA in the left subgenual cingulum, but the association with lower radial diffusivity was only a trend (p = 0.067). The Methods report 19 adolescents with ADHD were recruited; the Results clarify that two were excluded and the correlations used 17. (LLM, conf=0.92)

    Experimental — accuracy not yet measured

  • In ADHD, more constrained cingulum diffusion can be positively correlated with the severity of symptoms.

    “where more constrained cingulum diffusion can be positively correlated with the severity of symptoms (Cooper et al., 2015; but see also Chiang et al., 2016).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Cooper et al., 2015

  • In a study of 19 adolescents with ADHD, ADHD severity was associated with the status of the left cingulum close to the genu.

    “In a study of 19 adolescents with ADHD that focussed specifically on the cingulum (Cooper et al., 2015), ADHD severity was associated with the status of the left cingulum close to the genu”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Cooper et al., 2015

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Authors
Cooper, M., Thapar, A., & Jones, D. K.
Affiliations
Cardiff University (GB)
Corresponding author
Cooper, Miriam
ORCID
Venue
NeuroImage: Clinical
Publisher
Elsevier BV
Published
2015
Volume
7
Pages
653-660
ISSN
2213-1582 (ISSN-L)
DOI
10.1016/j.nicl.2015.02.012
PMC
PMC4375644
OpenAlex
W2137502695
Cited by
33
References
7
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 1
FWCI
2.98
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage Clinical (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Cardiff University Schools of Medicine and Psychology
  • Wellcome Trust (079711/Z/06/Z)
  • Medical Research Council (07/MRE/09/45)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
attention deficit hyperactivity disorder, ADHD symptom severity, white matter microstructure, corticospinal tract, autistic traits, fractional anisotropy, radial diffusivity, adolescents, diffusion MRI, deterministic tractography
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Brain, Humans, Male, Neural Pathways, Diffusion Tensor Imaging, White Matter

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