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Cited by 62Functional Brain Connectivity StudiesDementia and Cognitive Impairment ResearchAdvanced MRI Techniques and Applications

Multicenter stability of resting state fMRI in the detection of Alzheimer’s disease and amnestic MCI

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Teipel, Stefan J., Wohlert, Alexandra, Metzger, Coraline, Grimmer, Timo, Sorg, Christian, Ewers, Michael, Meisenzahl, Eva, Klöppel, Stefan +4 more·2017·NeuroImage: Clinical
DOI 10.1016/j.nicl.2017.01.018PMC PMC5279697
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Abstract

BACKGROUND: In monocentric studies, patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia exhibited alterations of functional cortical connectivity in resting-state functional MRI (rs-fMRI) analyses. Multicenter studies provide access to large sample sizes, but rs-fMRI may be particularly sensitive to multiscanner effects. METHODS: We used data from five centers of the "German resting-state initiative for diagnostic biomarkers" (psymri.org), comprising 367 cases, including AD patients, MCI patients and healthy older controls, to assess the influence of the distributed acquisition on the group effects. We calculated accuracy of group discrimination based on whole brain functional connectivity of the posterior cingulate cortex (PCC) using pooled samples as well as second-level analyses across site-specific group contrast maps. RESULTS: We found decreased functional connectivity in AD patients vs. controls, including clusters in the precuneus, inferior parietal cortex, lateral temporal cortex and medial prefrontal cortex. MCI subjects showed spatially similar, but less pronounced, differences in PCC connectivity when compared to controls. Group discrimination accuracy for AD vs. controls (MCI vs. controls) in the test data was below 76% (72%) based on the pooled analysis, and even lower based on the second level analysis stratified according to scanner. Only a subset of quality measures was useful to detect relevant scanner effects. CONCLUSIONS: Multicenter rs-fMRI analysis needs to employ strict quality measures, including visual inspection of all the data, to avoid seriously confounded group effects. While pending further confirmation in biomarker stratified samples, these findings suggest that multicenter acquisition limits the use of rs-fMRI in AD and MCI diagnosis.

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Authors
Teipel, S. J., Wohlert, A., Metzger, C., Grimmer, T., Sorg, C., Ewers, M., Meisenzahl, E., Klöppel, S., Borchardt, V., Grothe, M. J., Walter, M., & Dyrba, M.
Affiliations
  • German Center for Neurodegenerative Diseases (DE)
  • University of Rostock (DE)
  • TUM Klinikum (DE)
  • Institut für Schlaganfall- und Demenzforschung (DE)
  • LMU Klinikum (DE)
  • University of Freiburg (DE)
  • University of Tübingen (DE)
Corresponding author
Teipel, Stefan J.
ORCID
Venue
NeuroImage: Clinical
Publisher
Elsevier BV
Published
2017
Volume
14
Pages
183-194
ISSN
2213-1582 (ISSN-L)
DOI
10.1016/j.nicl.2017.01.018
PMC
PMC5279697
OpenAlex
W2573640914
Cited by
62
References
8
Citations by year
2026: 2 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 15 · 2019: 6 · 2018: 5 · 2017: 3
FWCI
4.55
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Max Planck Digital Library (submittedVersion)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by-nc-nd)
  • mediaTUM (Technical University of Munich) (submittedVersion)
  • DZNE Pub (submittedVersion, cc-by-nc-nd)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • Open Access CRIS of the University of Bern
Funders
  • Alzheimer Forschung Initiative
  • European Commission (334259)
  • Bundesministerium für Bildung und Forschung (1GQ1425B)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
resting-state fMRI, Alzheimer's disease, amnestic mild cognitive impairment, multicenter study, scanner effects, functional connectivity, posterior cingulate cortex, precuneus, diagnostic biomarkers, data quality metrics
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain Mapping, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Oxygen, Rest, Cognitive Dysfunction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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