Impaired default network functional connectivity in autosomal dominant Alzheimer disease
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OBJECTIVE: To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network. METHODS: Eighty-three mutation carriers and 37 asymptomatic noncarriers from the same families underwent fMRI during resting state at 8 centers in the United States, United Kingdom, and Australia. Using group-independent component analysis, fcMRI was compared using mutation status and Clinical Dementia Rating to stratify groups, and related to each participant's estimated years from expected symptom onset (eYO). RESULTS: We observed significantly decreased DMN fcMRI in mutation carriers with increasing Clinical Dementia Rating, most evident in the precuneus/posterior cingulate and parietal cortices (p < 0.001). Comparison of asymptomatic mutation carriers with noncarriers demonstrated decreased fcMRI in the precuneus/posterior cingulate (p = 0.014) and right parietal cortex (p = 0.0016). We observed a significant interaction between mutation carrier status and eYO, with decreases in DMN fcMRI observed as mutation carriers approached and surpassed their eYO. CONCLUSION: Functional disruption of the DMN occurs early in the course of autosomal dominant Alzheimer disease, beginning before clinically evident symptoms, and worsening with increased impairment. These findings suggest that DMN fcMRI may prove useful as a biomarker across a wide spectrum of disease, and support the feasibility of DMN fcMRI as a secondary endpoint in upcoming multicenter clinical trials in Alzheimer disease.
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Callosal white matter degeneration may contribute to functional disruption of functional networks such as the default mode network.
“our findings support the possibility that callosal white matter degeneration contribute to functional disruption of functional networks such as the default mode network (Chhatwal et al., 2013; Mueller and Weiner, 2017; Taylor et al., 2017)”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Chhatwal et al., 2013
The Discussion reports decreased default mode network connectivity in autosomal dominant Alzheimer disease. It does not identify callosal white matter degeneration as a possible contributor to that disruption (searched: callosal white matter degeneration; corpus callosum and structural connectivity). (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe default mode network shows reduced connectivity in early-stage Alzheimer's disease.
“a functional network showing reduced connectivity in early-stage Alzheimer’s disease (Sorg et al., 2007; Chhatwal et al., 2013)”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Chhatwal et al., 2013
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- Authors
- Chhatwal, J. P., Schultz, A. P., Johnson, K., Benzinger, T. L. S., Jack, C., Ances, B. M., Sullivan, C. A., Salloway, S. P., Ringman, J. M., Koeppe, R. A., Marcus, D. S., Thompson, P., Saykin, A. J., Correia, S., Schofield, P. R., Rowe, C. C., Fox, N. C., Brickman, A. M., Mayeux, R., McDade, E., Bateman, R., Fagan, A. M., Goate, A. M., Xiong, C., Buckles, V. D., Morris, J. C., & Sperling, R. A.
- Affiliations
- Harvard University (US)
- From the Departments of Neurology (J.P.C., A.P.S., K.J., C.A.S., R.A.S.) and Radiology (K.J.), and Martinos Center for Biomedical Imaging (J.P.C., A.P.S., K.J., C.A.S., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Section of Neuroradiology (T.L.S.B., D.S.M.), Mallinckrodt Institute of Radiology (T.L.S.B., B.M.A., D.S.M.), Departments of Neurology (B.M.A., R.B., A.M.F., V.D.B., J.C.M.), Genetics (A.M.G.), and Psychiatry (A.M.G.), and Division of...
- ORCID
- Chhatwal, Jasmeer P.
- Schultz, Aaron P.
- Johnson, Keith
- Benzinger, Tammie L.S.
- Jack, Clifford
- Ances, Beau M.
- Salloway, Stephen P.
- Ringman, John M.
- Koeppe, Robert A.
- Marcus, Daniel S.
- Thompson, Paul
- Saykin, Andrew J.
- Correia, Stephen
- Schofield, Peter R.
- Fox, Nick C.
- Brickman, Adam M.
- Mayeux, Richard
- McDade, Eric
- Bateman, Randall
- Fagan, Anne M.
- Xiong, Chengjie
- Morris, John C.
- Sperling, Reisa A.
- Venue
- Neurology
- Published
- 2013-08-20
- Volume
- 81
- Issue
- 8
- Pages
- 736-744
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3776464
- OpenAlex
- W2165942026
- Cited by
- 179
- References
- 42
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 33 · 2018: 18 · 2017: 19 · 2016: 10 · 2015: 12 · 2014: 24 · 2013: 1
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0508-10123)
- National Institute on Aging (K24AG035007, P50AG005134, U19AG032438, U24AG021886, P30AG062421)
- National Institute of Nursing Research (R01NR012657)
- National Institute of Neurological Disorders and Stroke (P30NS048056)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- autosomal dominant Alzheimer's disease, default mode network, functional connectivity, presenilin 1 mutations, amyloid precursor protein mutations, mutation carriers, asymptomatic carriers, precuneus, posterior cingulate cortex, parietal cortex, Clinical Dementia Rating, early biomarkers
- MeSH terms
- Adult, Alzheimer Disease, Brain, Female, Genes, Dominant, Heterozygote, Humans, Male, Nerve Net, Prevalence, Amyloid beta-Protein Precursor, Genetic Predisposition to Disease, Internationality, Presenilin-1, Presenilin-2, Connectome
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