Cited by 54Language Development and DisordersNeuroscience and Music PerceptionNeural dynamics and brain function

Reduced left-lateralized pattern of event-related EEG oscillations in infants at familial risk for language and learning impairment

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Cantiani, Chiara, Ortiz-Mantilla, Silvia, Riva, Valentina, Piazza, Caterina, Bettoni, Roberta, Musacchia, Gabriella, Molteni, Massimo, Marino, Cecilia +1 more·2019·NeuroImage: Clinical

Abstract

The ability to rapidly discriminate successive auditory stimuli within tens-of-milliseconds is crucial for speech and language development, particularly in the first year of life. This skill, called Rapid Auditory Processing (RAP), is altered in infants at familial risk for language and learning impairment (LLI) and is a robust predictor of later language outcomes. In the present study, we investigate the neural substrates of RAP, i.e., the underlying neural oscillatory patterns, in a group of Italian 6-month-old infants at risk for LLI (FH+, n = 24), compared to control infants with no known family history of LLI (FH-, n = 32). Brain responses to rapid changes in fundamental frequency and duration were recorded via high-density electroencephalogram during a non-speech double oddball paradigm. Sources of event-related potential generators were localized to right and left auditory regions in both FH+ and FH- groups. Time-frequency analyses showed variations in both theta (Ɵ) and gamma (ɣ) ranges across groups. Our results showed that overall RAP stimuli elicited a more left-lateralized pattern of oscillations in FH- infants, whereas FH+ infants demonstrated a more right-lateralized pattern, in both the theta and gamma frequency bands. Interestingly, FH+ infants showed reduced early left gamma power (starting at 50 ms after stimulus onset) during deviant discrimination. Perturbed oscillatory dynamics may well constitute a candidate neural mechanism to explain group differences in RAP. Additional group differences in source location suggest that anatomical variations may underlie differences in oscillatory activity. Regarding the predictive value of early oscillatory measures, we found that the amplitude of the source response and the magnitude of oscillatory power and phase synchrony were predictive of expressive vocabulary at 20 months of age. These results further our understanding of the interplay among neural mechanisms that support typical and atypical rapid auditory processing in infancy.

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  • A recent study comparing two groups of 6-month-old infants with different risk levels for Language and Learning Impairment in auditory processing using EEG reported a main effect of group on the amplitude of an EEG feature with Cohen's d = 0.706.

    “An a priori power analysis was conducted based on a recent study that compared two groups of 6-month-old infants with different risk levels for Language and Learning Impairment in their auditory processing using EEG [47]. The main effect of group on the amplitude of an EEG feature was reported to have an effect size (Cohen’s d) of 0.706.”

    From Tracking Acquisition of Language in Kids (TALK) study protocol: A longitudinal investigation of infants at high vs. low risk for atypical speech and language development (2026) · cites this paper as [47]

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Authors
Cantiani, C., Ortiz-Mantilla, S., Riva, V., Piazza, C., Bettoni, R., Musacchia, G., Molteni, M., Marino, C., & Benasich, A. A.
Affiliations
  • IRCCS Eugenio Medea (IT)
  • University of the Pacific (US)
  • Centre for Addiction and Mental Health (CA)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
Cantiani, Chiara
Venue
NeuroImage: Clinical
Publisher
Elsevier BV
Published
2019
Volume
22
Pages
101778
ISSN
2213-1582 (ISSN-L)
OpenAlex
W2921851153
Cited by
54
References
133
Citations by year
2026: 1 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 3 · 2017: 1
FWCI
14.11
Type
journal article
Language
en
Open access
Locations
  • NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
  • Scholarly Commons (University of the Pacific) (submittedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Fondazione del Monte di Bologna e Ravenna
Topics
  • Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
infants, event-related oscillations, theta oscillations, gamma oscillations, auditory cortex, source localization, language development, learning disabilities
MeSH terms
Auditory Cortex, Auditory Perception, Electroencephalography, Evoked Potentials, Auditory, Humans, Infant, Language Development, Language Development Disorders, Functional Laterality, Learning Disabilities, Theta Rhythm, Vocabulary, Genetic Predisposition to Disease, Electroencephalography Phase Synchronization, Gamma Rhythm

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