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Dinitrosyl iron complexes with thiolate ligands: Physico-chemistry, biochemistry and physiology
Abstract
Some present-day concepts on the origin and functional activities of dinitrosyl iron complexes (DNIC) with thiolate ligands are considered. Nitric oxide (NO) including to DNIC increases its stability and ensures effective targeting of NO to organs and tissues. DNIC have a square-planar structure; unpaired electron is localized on the d(z2) orbital of the d(7) iron atom. The formula of DNIC appears as [(RS(-))(2)Fe(+)(NO(+))(2)....((-)SR)(2)](-); electron spin is S=1/2. Conversion of an originally diamagnetic group, Fe(2+)(NO)(2) with electron configuration d(8), into a paramagnetic Fe(+)(NO(+))(2) group is a result of disproportionation of NO ligands and substitution of newly generated NO(-) for NO. The nitrosonium ions present in DNIC impart to them high nitrosylating activity, e.g., ability to induce S-nitrosylation of thiols. The ability of S-nitrosothiols to form DNIC in a direct reaction with bivalent iron is a prerequisite to effective mutual conversions of DNIC and S-nitrosothiols. In this work, I consider some mechanisms of destructive effects of low-molecular DNIC on active centers of iron-sulfur proteins, ability of DNIC to express certain genes, to activate guanylate cyclase, to exert hypotensive, vasodilator effects, to inhibit platelet aggregation, to accelerate wound healing and to produce potent erective action. Recently a stabilized powder-like polymeric composition based on dimeric glutathione DNIC the water-soluble polymer in which was used as a filling agent was designed. The advantages of this stable DNIC-glutathione preparation include their ability to retain their physico-chemical and functional activities within at least one year. At present, the preparation undergo testing as a base for the design of a wide variety of broad-spectrum drugs.
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“It was proposed that DNICs are formed in the vasculature from nitrosothiols and that they are in equilibrium with the nitrosothiol pool [103,104].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [103]
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Research works printed but not linked: 19
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Self-citationDamasceno, F. C. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.59.2016.tde-20042016-065052
Belovolova, L. V., Vinogradov, E. A., & Glushkov, M. V. (2013)
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Landry, A. P. (2015) · Louisiana State University · doi:10.31390/gradschool_dissertations.398
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Мартусевич, А. К., Соловьева, А. Г., Kovaleva, L. K., & Мартусевич, А. А. (2018) · Trace Elements in Medicine (Moscow) · doi:10.19112/2413-6174-2018-19-4-52-58
Мартусевич, А. К., Kovaleva, L. K., & Мартусевич, А. А. (2018) · Trace Elements in Medicine (Moscow) · doi:10.19112/2413-6174-2017-18-4-18-21
РАН, Ф. В. Н.-И. И. Т. И. П., & ДОЛГОРУКОВА, А. М. (2020) · Sel skokhozyaistvennaya Biologiya · doi:10.15389/agrobiology.2020.4.794rus
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Pregnan X Receptor Functioning under Conditions of Nitrosative Stress
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Glutathione: Chemistry and Biochemistry
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Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study
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Metadata
- Authors
- Vanin, A. F.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Vanin, Anatoly F.
- ORCID
- Vanin, Anatoly F.
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 21
- Issue
- 1
- Pages
- 1-13
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W2044091187
- Cited by
- 217
- References
- 126
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 9 · 2018: 15 · 2017: 15 · 2016: 13 · 2015: 16 · 2014: 28 · 2013: 21 · 2012: 19
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Foundation for Basic Research
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Keywords
- dinitrosyl iron complexes, thiolate ligands, nitrosonium ion, S-nitrosylation, S-nitrosothiols, iron-sulfur proteins, guanylate cyclase activation, platelet aggregation inhibition, wound healing, erectile function, glutathione, polymeric drug delivery
- MeSH terms
- Animals, Electron Spin Resonance Spectroscopy, Iron, Liver, Nitric Oxide, Nitrogen Oxides, Sulfhydryl Compounds, Chemical Phenomena
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