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Cited by 217Nitric Oxide and Endothelin EffectsHemoglobin structure and functionMetal-Catalyzed Oxygenation Mechanisms

The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.

Dinitrosyl iron complexes with thiolate ligands: Physico-chemistry, biochemistry and physiology

Vanin, Anatoly F.·2009·Nitric Oxide
DOI 10.1016/j.niox.2009.03.005
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Abstract

Some present-day concepts on the origin and functional activities of dinitrosyl iron complexes (DNIC) with thiolate ligands are considered. Nitric oxide (NO) including to DNIC increases its stability and ensures effective targeting of NO to organs and tissues. DNIC have a square-planar structure; unpaired electron is localized on the d(z2) orbital of the d(7) iron atom. The formula of DNIC appears as [(RS(-))(2)Fe(+)(NO(+))(2)....((-)SR)(2)](-); electron spin is S=1/2. Conversion of an originally diamagnetic group, Fe(2+)(NO)(2) with electron configuration d(8), into a paramagnetic Fe(+)(NO(+))(2) group is a result of disproportionation of NO ligands and substitution of newly generated NO(-) for NO. The nitrosonium ions present in DNIC impart to them high nitrosylating activity, e.g., ability to induce S-nitrosylation of thiols. The ability of S-nitrosothiols to form DNIC in a direct reaction with bivalent iron is a prerequisite to effective mutual conversions of DNIC and S-nitrosothiols. In this work, I consider some mechanisms of destructive effects of low-molecular DNIC on active centers of iron-sulfur proteins, ability of DNIC to express certain genes, to activate guanylate cyclase, to exert hypotensive, vasodilator effects, to inhibit platelet aggregation, to accelerate wound healing and to produce potent erective action. Recently a stabilized powder-like polymeric composition based on dimeric glutathione DNIC the water-soluble polymer in which was used as a filling agent was designed. The advantages of this stable DNIC-glutathione preparation include their ability to retain their physico-chemical and functional activities within at least one year. At present, the preparation undergo testing as a base for the design of a wide variety of broad-spectrum drugs.

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Research works printed but not linked: 19

  1. Vanin, 1967, Investigation of non-heme iron complexes in cells and tissues by the EPR method, Biofizika (Rus), 12, 829
  2. Vanin, 1967, Identification of divalent iron complexes with cysteine in biological systems, Biokhimiya (Rus), 32, 228
  3. A.F. Vanin, L.A. Blumenfeld, D.Sh. Burbaev, I.L. Lisovskaya, A.G. Chetverikov, Investigations of some iron complexes in biological objects, Proceedings of the International Jubilee Conference on Paramagnetic Resonance, 1969 June 15–20, Kazan, Part 1 (1970) 218–223.
  4. Vanin, 1971, Endogenous heme and non-heme nitrosyl iron complexes in cells and tissues, Biofizika (Rus), 16, 650
  5. Mikoyan, 2004, Formation of paramagnetic nitrosyl complexes of nonheme iron in the animal organism with the participation of nitric oxide from exogenous and endogenous sources, Biophysics (Translation from Russian), 41, 110
  6. Vanin, 1992, Dinitrosyl-iron complexes with thiol-containing ligands and their reversible transformation into nitrosothiols, Biokhimiya (Rus), 58, 1103
  7. A.F. Vanin, Nitrosyl non-heme iron complexes in animal tissues and microorganisms, D.Sc.Thesis, Institute of Chemical Physics, Moscow, 1980.
  8. Burbaev, 1971, Electronic and spatial structures of paramagnetic dinitrosyl ferrous complexes, Zhurnal Strukt. Khimii (Rus), 2, 252
  9. Sanina, 2004, Structure of neutral mononuclear dinitrosyl iron complex with 1,2,4-triazole-3-thione [Fe(SC3H3N3)2(NO)2]0.5H2O, Mendeleev Communs., 1, 1
  10. Vanin, 1975, On the origin of paramagnetic centers at g=2.03 in animal tissues and microorganisms, Studia Biofizika, 49, 13
  11. Vanin, 1980, On the mechanism of nitrosyl non-heme iron formation in animal tissue, Studia Biofizika, 80, 221
  12. Voevodskaya, 1999, The nitric oxide-mediated degradation of active center in an iron-sulphur protein adrenodoxin, Current Top. Biophys., 23, 31
  13. Kleschyov, 1985, Role of nitric oxide and iron in hypotensive action of nitrosyl iron complexes with various anionic ligands, Studia Biofizika, 105, 93
  14. Mordvintcev, 1988, Hypotensive activity of dinitrosyl complexes of iron in narcotized animals, Bulleten Vsesoyuznogo Kardiol. Nauchnogo Tsentra SSSR, 1, 46
  15. Galagan, 1988, Hypotensive effect of dinitrosyl complexes of iron in conscious animals, Bulleten Vsesoyuznogo Kardiol. Nauchnogo Centra SSSR, 2, 75
  16. Van der Viet, 1998, Formation of S-nitrosothiols via direct nucleophylic nitrosation of thiols by peroxynitrite with elimination of hydrogen peroxide, J. Biol. Chem., 273, 30225
  17. Mordvintcev, 1986, The inhibitory effect of low-molecular dinitrosyl iron complexes on platelet aggregation, Biokhimiya (Rus), 51, 1851
  18. Kuznetsov, 1988, Low-molecular and protein-bound dinitrosyl iron complexes as inhibitors of platelet aggregation, Voprosy Med. Khimii, 5, 43
  19. Kurbanov, 1989, Effects of thiol-containing compounds and iron on the formation of nitric oxide from nitroprusside and nitroglycerine, Voprosy Med Khimii (Rus), 6, 87

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Metadata

Authors
Vanin, A. F.
Affiliations
Russian Academy of Sciences (RU)
Corresponding author
Vanin, Anatoly F.
ORCID
Vanin, Anatoly F.
Venue
Nitric Oxide
Publisher
Elsevier BV
Published
2009-08
Volume
21
Issue
1
Pages
1-13
ISSN
1089-8603 (ISSN-L)
DOI
10.1016/j.niox.2009.03.005
OpenAlex
W2044091187
Cited by
217
References
126
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 9 · 2018: 15 · 2017: 15 · 2016: 13 · 2015: 16 · 2014: 28 · 2013: 21 · 2012: 19
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nitric Oxide (publishedVersion)
  • PubMed (publishedVersion)
Funders
Russian Foundation for Basic Research
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
  • Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Keywords
dinitrosyl iron complexes, thiolate ligands, nitrosonium ion, S-nitrosylation, S-nitrosothiols, iron-sulfur proteins, guanylate cyclase activation, platelet aggregation inhibition, wound healing, erectile function, glutathione, polymeric drug delivery
MeSH terms
Animals, Electron Spin Resonance Spectroscopy, Iron, Liver, Nitric Oxide, Nitrogen Oxides, Sulfhydryl Compounds, Chemical Phenomena

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