P46. Acute effects of dietary nitrate on glucose handling and insulin levels during an oral glucose tolerance test in healthy subjects
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Approximately 60 % of ingested nitrate is excreted in urine within 48 h.
“Approximately 60 % of ingested nitrate is excreted in urine within 48 h.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [10]
The remaining nitrite is absorbed into the circulation; in blood vessels nitrite forms vasodilatory NO after a reaction with deoxygenated Hb.
“The remaining nitrite is absorbed into the circulation; in blood vessels (c) nitrite forms vasodilatory NO after a reaction with deoxygenated Hb (deoxy-Hb).”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [10]
Approximately 25 % of ingested nitrate is taken up from the circulation and concentrated in the salivary glands and re-secreted into the mouth, where it is reduced to nitrite.
“Approximately 25 % is taken up from the circulation and concentrated in the salivary glands and re-secreted into the mouth, where it is reduced to nitrite (adapted from Lundberg et al.(10) ).”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [10]
A proportion of ingested nitrate is converted directly to nitrite by facultative anaerobic bacteria that reside on the dorsum of the tongue during mastication in the mouth.
“A proportion of ingested nitrate (NO 32 , ---Q) is converted directly to nitrite (NO 2 2 , ! ) by facultative anaerobic bacteria, that reside on the dorsum of the tongue, during mastication in the mouth (a); the remainder is swallowed and is rapidly absorbed from the upper gastrointestinal tract.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [10]
The remainder of ingested nitrate is swallowed and rapidly absorbed from the upper gastrointestinal tract.
“A proportion of ingested nitrate (NO 32 , ---Q) is converted directly to nitrite (NO 2 2 , ! ) by facultative anaerobic bacteria, that reside on the dorsum of the tongue, during mastication in the mouth (a); the remainder is swallowed and is rapidly absorbed from the upper gastrointestinal tract.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [10]
Some salivary nitrite enters the acidic environment of the stomach where NO is produced non-enzymically from nitrite after formation of nitrous acid and then NO and other nitrogen oxides.
“Some of the salivary nitrite enters the acidic environment of the stomach once swallowed (b), where NO is produced non-enzymically from nitrite after formation of nitrous acid (HNO 2 ) and then NO and other nitrogen oxides.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [10]
The NO generated in the stomach kills pathogenic bacteria and stimulates mucosal blood flow and mucus generation.
“The NO generated kills pathogenic bacteria and stimulates mucosal blood flow and mucus generation.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [10]
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Siervo, M., Lara, J., Ogbonmwan, I., & Mathers, J. C. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.170233 · Cited by 375 · see citing works
Dietary flavonoids and nitrate: effects on nitric oxide and vascular function
Bondonno, C. P., Croft, K. D., Ward, N., Considine, M. J., & Hodgson, J. M. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu014 · Cited by 150 · see citing works
Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000188 · Cited by 114 · see citing works
Goh, C. E., Trinh, P., Colombo, P. C., Genkinger, J. M., Mathema, B., Uhlemann, A., LeDuc, C. A., Leibel, R. L., Rosenbaum, M. S., Paster, B. J., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013324 · Cited by 82 · see citing works
Ashor, A. W., Chowdhury, S., Oggioni, C., Qadir, O., Brandt, K., Ishaq, A., Mathers, J. C., Saretzki, G. C., & Siervo, M. (2016) · Journal of Nutrition · doi:10.3945/jn.116.237529 · Cited by 55 · see citing works
Goh, C. E. (2018) · doi:10.7916/d8ff596v · Cited by 1 · see citing works
- Authors
- Lidder, S., Hunt, J., Omar, S., & Webb, A.
- Affiliations
- King's College London (GB)
- ORCID
- Omar, Sami
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 24
- Pages
- S32
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W2079079952
- Cited by
- 6
- References
- 0
- Citations by year
- 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2013: 2
- Type
- conference abstract
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- dietary nitrate, glucose handling, insulin levels, oral glucose tolerance test, acute effects, healthy volunteers
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