Dietary nitrite attenuates oxidative stress and activates antioxidant genes in rat heart during hypobaric hypoxia
Abstract
The nitrite anion represents the circulatory and tissue storage form of nitric oxide (NO) and a signaling molecule, capable of conferring cardioprotection and many other health benefits. However, molecular mechanisms for observed cardioprotective properties of nitrite remain largely unknown. We have evaluated the NO-like bioactivity and cardioprotective efficacies of sodium nitrite supplemented in drinking water in rats exposed to short-term chronic hypobaric hypoxia. We observed that, nitrite significantly attenuates hypoxia-induced oxidative stress, modulates HIF-1α stability and promotes NO-cGMP signaling in hypoxic heart. To elucidate potential downstream targets of nitrite during hypoxia, we performed a microarray analysis of nitrite supplemented hypoxic hearts and compared with both hypoxic and nitrite supplemented normoxic hearts respectively. The analysis revealed a significant increase in the expression of many antioxidant genes, transcription factors and cardioprotective signaling pathways which was subsequently confirmed by qRT-PCR and Western blotting. Conversely, hypoxia exposure increased oxidative stress, activated inflammatory cytokines, downregulated ion channels and altered expression of both pro- and anti-oxidant genes. Our results illustrate the physiological function of nitrite as an eNOS-independent source of NO in heart profoundly modulating the oxidative status and cardiac transcriptome during hypoxia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nitrite supplementation preserves or increases antioxidant capacity in the heart in a rat model of high altitude-induced hypoxia.
“and in a rat model of high altitude-induced hypoxia (172)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [172]
Cites
A fluorometric method for determination of oxidized and reduced glutathione in tissues
Hissin, P. J., & Hilf, R. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90326-2 · Cited by 4,116 · see citing works
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works
Oxygen, oxidative stress, hypoxia, and heart failure
Giordano, F. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24408 · Cited by 1,494 · see citing works
The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease
Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00010 · Cited by 1,396 · see citing works
Hackett, P. H., & Roach, R. C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107123450206 · Cited by 1,322 · see citing works
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704 · see citing works
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · see citing works
Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · see citing works
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works
Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works
Basnyat, B., & Murdoch, D. R. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13591-x · Cited by 543 · see citing works
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., Maloney, R. E., Bharti, A., Rodriguez, J., & Feelisch, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio734 · Cited by 518 · see citing works
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works
Hendgen-Cotta, U. B., Merx, M. W., Shiva, S., Schmitz, J., Becher, S., Klare, J. P., Steinhoff, H.-J., Goedecke, A., Schrader, J., Gladwin, M. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801336105 · Cited by 418 · see citing works
Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans
ERZURUM, S. C., Ghosh, S., Janocha, A. J., Xu, W., Bauer, S. M., Bryan, N. S., Tejero, J., Hemann, C. F., Hille, R., Stuehr, D. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707462104 · Cited by 364 · see citing works
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
Bryan, N. S., Calvert, J. W., Elrod, J. W., Gundewar, S., Ji, S. Y., & Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706579104 · Cited by 347 · see citing works
Gladwin, M. T., Raat, N. J. H., Shiva, S., Dezfulian, C., Hogg, N., Kim-Shapiro, D. B., & Patel, R. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2006 · Cited by 329 · see citing works
Rassaf, T., Flögel, U., Drexhage, C., Hendgen-Cotta, U., Kelm, M., & Schrader, J. (2007) · Circulation Research · doi:10.1161/circresaha.107.152488 · Cited by 284 · see citing works
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281 · see citing works
Crowe, F. L., Roddam, A. W., Key, T. J., Appleby, P. N., Overvad, K., Jakobsen, M. U., Tjonneland, A., Hansen, L., Boeing, H., Weikert, C., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq465 · Cited by 263 · see citing works
Carlström, M., Persson, A. E. G., Larsson, E., Hezel, M., Scheffer, P. G., Teerlink, T., Weitzberg, E., & Lundberg, J. O. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq366 · Cited by 261 · see citing works
Jung, K.-H., Chu, K., Ko, S.-Y., Lee, S.-T., Sinn, D.-I., Park, D.-K., Kim, J.-M., Song, E.-C., Kim, M., & Roh, J.-K. (2006) · Stroke · doi:10.1161/01.str.0000245116.40163.1c · Cited by 253 · see citing works
Lehr, H., van der Loss, C. M., Teeling, P., & Gown, A. M. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904700113 · Cited by 221 · see citing works
Hypoxia Decreases Exhaled Nitric Oxide in Mountaineers Susceptible to High-Altitude Pulmonary Edema
Busch, T., Bärtsch, P., Pappert, D., Grünig, E., Hildebrandt, W., Elser, H., Falke, K. J., & Swenson, E. R. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.2001134 · Cited by 218 · see citing works
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198 · see citing works
Zuckerbraun, B. S., Shiva, S., Ifedigbo, E., Mathier, M. A., Mollen, K. P., Rao, J., Bauer, P. M., Choi, J. J. W., Curtis, E., Choi, A. M. K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.891077 · Cited by 192 · see citing works
Gonzalez, F. M., Shiva, S., Vincent, P. S., Ringwood, L. A., Hsu, L.-Y., Hon, Y. Y., Aletras, A. H., Cannon, R. O., Gladwin, M. T., & Arai, A. E. (2008) · Circulation · doi:10.1161/circulationaha.107.748814 · Cited by 175 · see citing works
Insulin says NO to cardiovascular disease
Yu, Q., Gao, F., & Ma, X. L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq349 · Cited by 172 · see citing works
Bryan, N. S., Calvert, J. W., Gundewar, S., & Lefer, D. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.040 · Cited by 161 · see citing works
Hypoxia Impairs Systemic Endothelial Function in Individuals Prone to High-Altitude Pulmonary Edema
Berger, M. M., Hesse, C., Dehnert, C., Siedler, H., Kleinbongard, P., Bardenheuer, H. J., Kelm, M., Bärtsch, P., & Haefeli, W. E. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-654oc · Cited by 160 · see citing works
Montenegro, M. F., Amaral, J. H., Pinheiro, L. C., Sakamoto, E. K., Ferreira, G. C., Reis, R. I., Marçal, D. M. O., Pereira, R. P., & Tanus-Santos, J. E. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.005 · Cited by 152 · see citing works
Plasma malonaldehyde levels during myocardial infarction
Dousset, J.-C., Trouilh, M., & Foglietti, M. J. (1983) · Clinica Chimica Acta · doi:10.1016/0009-8981(83)90035-9 · Cited by 141 · see citing works
Cardiac adaptation to chronic high-altitude hypoxia: Beneficial and adverse effects
Ošťádal, B., & Kolář, F. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2007.03.005 · Cited by 130 · see citing works
Bailey, D. M., Dehnert, C., Luks, A. M., Menold, E., Castell, C., Schendler, G., Faoro, V., Gutowski, M., Evans, K. A., Taudorf, S., et al. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.194704 · Cited by 121 · see citing works
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works
Safety and Feasibility of Long-term Intravenous Sodium Nitrite Infusion in Healthy Volunteers
Pluta, R. M., Oldfield, E. H., Bakhtian, K. D., Fathi, A. R., Smith, R. K., DeVroom, H. L., Nahavandi, M., Woo, S., Figg, W. D., & Lonser, R. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014504 · Cited by 112 · see citing works
Alef, M. J., Vallabhaneni, R., Carchman, E., Morris, S. M., Shiva, S., Wang, Y., Kelley, E. E., Tarpey, M. M., Gladwin, M. T., Tzeng, E., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44079 · Cited by 101 · see citing works
Guo, R., Ma, H., Gao, F., Zhong, L., & Ren, J. T. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.03.018 · Cited by 100 · see citing works
Raat, N. J. H., Noguchi, A. C., Liu, V. B., Raghavachari, N., Liu, D., Xu, X., Shiva, S., Munson, P. J., & Gladwin, M. T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.015 · Cited by 97 · see citing works
Xu, J., Wang, G., Wang, Y., Liu, Q., Xu, W., Tan, Y., & Cai, L. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00833.x · Cited by 95 · see citing works
Clarke, C. R. A. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2006.047662 · Cited by 83 · see citing works
Myocardial protection by nitrite
Calvert, J. W., & Lefer, D. J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp079 · Cited by 82 · see citing works
Fan, C., Iacobaş, D. A., Zhou, D., Chen, Q., Lai, J. C. K., Gavrialov, O., & Haddad, G. G. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00217.2004 · Cited by 82 · see citing works
Systemic Vascular Dysfunction in Patients With Chronic Mountain Sickness
Rimoldi, S. F., Rexhaj, E., Pratali, L., Bailey, D. M., Hutter, D., Faita, F., Salmón, C. S., Villena, M., NICOD, P. H., Allemann, Y., et al. (2011) · CHEST Journal · doi:10.1378/chest.11-0342 · Cited by 81 · see citing works
Cauwels, A., Buys, E. S., Thoonen, R., Geary, L., Delanghe, J., Shiva, S., & Brouckaert, P. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20091236 · Cited by 80 · see citing works
Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy
Sharma, S., Taegtmeyer, H., Adrogue, J. V., Razeghi, P., Sen, S., Ngumbela, K. C., & Essop, M. F. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00916.2003 · Cited by 78 · see citing works
Hypoxia-Induced Signaling in the Cardiovascular System
Simon, M. C., Liu, L., Barnhart, B. C., & Young, R. M. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100526 · Cited by 78 · see citing works
Martorell, L., Gentile, M., Rius, J., Rodrı́guez, C., Crespo, J., Badimón, L., & Martínez‐González, J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00945-09 · Cited by 72 · see citing works
Vitturi, D. A., & Patel, R. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.037 · Cited by 59 · see citing works
Hu, L., Pan, T., Neo, K. L., Yong, Q. C., & Bian, J. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0346-8 · Cited by 58 · see citing works
Perlman, D. H., Bauer, S. M., Ashrafian, H., Bryan, N. S., Garcia-Saura, M. F., Lim, C. C., Fernandez, B. O., Infusini, G., McComb, M. E., Costello, C. E., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.187005 · Cited by 56 · see citing works
Sethy, N. K., Singh, M., Kumar, R., Ilavazhagan, G., & Bhargava, K. (2010) · Functional & Integrative Genomics · doi:10.1007/s10142-010-0195-y · Cited by 48 · see citing works
Self-citationExhaled nitric oxide decreases upon acute exposure to high-altitude hypoxia
Brown, D. E., Beall, C. M., Strohl, K. P., & Mills, P. S. (2006) · American Journal of Human Biology · doi:10.1002/ajhb.20489 · Cited by 46 · see citing works
Constitutive COX-2 activity in cardiomyocytes confers permanent cardioprotection
Inserte, J., Mollá, B., Aguilar, R., Través, P. G., Barba, I., Martín‐Sanz, P., Boscá, L., Casado, M., & David Garcia-dorado, A. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.11.011 · Cited by 44 · see citing works
Adrogue, J. V., Sharma, S., Ngumbela, K. C., Essop, M. F., & Taegtmeyer, H. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-6629-5 · Cited by 37 · see citing works
Iacobaş, D. A., Fan, C., Iacobaş, S., & Haddad, G. G. (2008) · Functional & Integrative Genomics · doi:10.1007/s10142-008-0082-y · Cited by 35 · see citing works
Pellegrino, D., Shiva, S., Angelone, T., Gladwin, M. T., & Tota, B. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.02.007 · Cited by 30 · see citing works
Karar, J., Dolt, K. S., Mishra, M. K., Arif, E., Javed, S., & Pasha, M. A. Q. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.08.044 · Cited by 29 · see citing works
Pattillo, C. B., Fang, K., Pardue, S., & Kevil, C. G. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.008 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bhargava, Arya, A., Sethy, N. K., Singh, S. K., & Das, M. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s53032 · Cited by 123 · see citing works
Self-citationGheibi, S., Jeddi, S., Carlström, M., Gholami, H., & Ghasemi, A. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.02.002 · Cited by 90 · see citing works
Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension
Amaral, J. H., Ferreira, G. C., Pinheiro, L. C., Montenegro, M. F., & Tanus-Santos, J. E. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.009 · Cited by 75 · see citing works
Cabrales, P., & Intaglietta, M. (2013) · ASAIO Journal · doi:10.1097/mat.0b013e318291fbaa · Cited by 74 · see citing works
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works
Ansari, F. A., Ali, S. N., Arif, H., Khan, A. A., & Mahmood, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175196 · Cited by 49 · see citing works
Feelisch, M., Akaike, T., Griffiths, K., Ida, T., Prysyazhna, O. D., Goodwin, J. J., Gollop, N. D., Fernandez, B. O., Minnion, M., Cortese-Krott, M. M., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz202 · Cited by 47 · see citing works
Santharaman, P., Venkatesh, K. A., Kanagavel, V., Benjamin, A. R., Sethy, N. K., Bhargava, K., & Karunakaran, C. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.10.039 · Cited by 44 · see citing works
Self-citationChtourou, Y., Garoui, E. M., Boudawara, T. S., & Zeghal, N. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112455674 · Cited by 41 · see citing works
Ling, W. C., Mustafa, M. R., Vanhoutte, P. M., & Murugan, D. D. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.05.003 · Cited by 40 · see citing works
Cabrales, P., & Friedman, J. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5099.test · Cited by 37 · see citing works
Stacey, B. S., Hoiland, R. L., Caldwell, H. G., Howe, C. A., Vermeulen, T. D., Tymko, M. M., Vizcardo‐Galindo, G. A., Bermúdez, D., Figueroa‐Mujíca, R., Gasho, C., et al. (2023) · The Journal of Physiology · doi:10.1113/jp283362 · Cited by 34 · see citing works
Cabrales, P., & Friedman, J. M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5099 · Cited by 44 · see citing works
Justice, J. N., Gioscia‐Ryan, R. A., Johnson, L. C., Battson, M. L., de Picciotto, N., Beck, H. J., Jiang, H., Sindler, A. L., Bryan, N. S., Enoka, R. M., et al. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00608.2014 · Cited by 31 · see citing works
Pinheiro, L. C., Amaral, J. H., Ferreira, G. C., Montenegro, M. F., Oliveira‐Paula, G. H., & Tanus-Santos, J. E. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.05.009 · Cited by 26 · see citing works
Jing, L., Shao, J., Sun, W., Lan, T., Jia, Z., Ma, H., & Wang, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.037 · Cited by 26 · see citing works
Balamurugan, M., Thangamuthu, M., Manickam, P., Bhargava, K., Sethy, N. K., & Karunakaran, C. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.01.025 · Cited by 24 · see citing works
Self-citationAcclimatization to long-term hypoxia: gene expression in ovine carotid arteries
Goyal, R., & Longo, L. D. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00073.2014 · Cited by 24 · see citing works
Singh, M., Padhy, G., Vats, P., Bhargava, K., & Sethy, N. K. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.015 · Cited by 22 · see citing works
Self-citationBiswas, I., Garg, I., Singh, B., & Khan, G. A. (2012) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2012.05.001 · Cited by 19 · see citing works
Gangwar, A., Paul, S., Ahmad, Y., & Bhargava, K. (2018) · Biochimie · doi:10.1016/j.biochi.2018.03.009 · Cited by 17 · see citing works
Self-citationBahadoran, Z., Mirmiran, P., Jeddi, S., Carlström, M., Azizi, F., & Ghasemi, A. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1587168 · Cited by 17 · see citing works
Protective effect of exogenous nitrite in postoperative ileus
Cosyns, S., Shiva, S., & Lefebvre, R. A. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13255 · Cited by 13 · see citing works
Anti-oxidant effect of nitrite in the pancreatic islets of type 2 diabetic male rats.
Ghasemi, A., Gheibi, S., Kashfi, K., & Jeddi, S. (2023) · PubMed Central · doi:10.22038/ijbms.2023.68245.14900 · Cited by 11 · see citing works
Dietary nitrate supplementation mitigates age‐related changes at the neuromuscular junction in mice
Rossi, M., Zuccarelli, L., Brocca, L., Sazzi, C., Gissi, C., Rossi, P., Grassi, B., Porcelli, S., Bottinelli, R., & Pellegrino, M. A. (2025) · The Journal of Physiology · doi:10.1113/jp287592 · Cited by 7 · see citing works
Liu, P., Fu, L., Li, B., Man, M., Ji, Y., Kang, Q., Sun, X., Shen, D., & Chen, L. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-23688-0 · Cited by 7 · see citing works
Ahmad, Y., Mishra, S., Arya, A., Paul, S., Sharma, M., Prasad, J., & Bhargava, K. (2016) · Functional & Integrative Genomics · doi:10.1007/s10142-016-0483-2 · Cited by 7 · see citing works
Self-citationNitrate and Nitrite in Aging and Age-Related Disease
Johnson, L. C., DeVan, A. E., Justice, J. N., & Seals, D. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_18 · Cited by 5 · see citing works
Rebelo, M. A., Cássia-Barros, A., Conde-Tella, S. O., Frugeri, S. F., Ovídio, P. P., Jordão, A. A., Filho, C. K. C., Lacchini, R., Silva, A. O., Tirapellli, C. R., et al. (2025) · Antioxidants · doi:10.3390/antiox14111307 · Cited by 2 · see citing works
Петенкова, А. А., Kovalenko, R., & Ad, N. (2013) · Doklady Biological Sciences · doi:10.1134/s0012496613030083 · Cited by 1 · see citing works
Кулева, Н. В., Krasovskaia, I. E., & Евгеньевна, Ш. Т. (2014) · BIOPHYSICS · doi:10.1134/s0006350914050121 · Cited by 1 · see citing works
High Altitude Related Diseases: Milder Effects, HACE, HAPE, and Effect on Various Organ Systems
Singh, S., & Ansari, M. A. (2022) · Springer eBooks · doi:10.1007/978-981-19-1008-1_3 · Cited by 1 · see citing works
Guimarães, D. A., & Tanus-Santos, J. E. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13835 · Cited by 1 · see citing works
Plotkin, B. J., Sigar, I. M., & Kaminski, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.24.445475
Putative pathways fueling anaerobic mitochondrial respiration
Plotkin, B. J., Sigar, I. M., Kaminski, A., & Konaklieva, M. I. (2022) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2022.14.2.0464
Nanoceria and Hypoxia: Promises and Challenges
Arya, A., Singh, S., & Kumar, A. (2023) · Smart nanomaterials technology · doi:10.1007/978-981-99-1718-1_21
Self-citationInvestigating the role of nitric oxide clones in cardiovascular conditions
Arif, S. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
- Authors
- Singh, M., Arya, A., Kumar, R., Bhargava, K., & Sethy, N. K.
- Affiliations
- Defence Research and Development Organisation (IN)
- Corresponding author
- Bhargava, Kalpana
- Sethy, Niroj Kumar
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 26
- Issue
- 1
- Pages
- 61-73
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W2065234547
- Cited by
- 38
- References
- 59
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 3 · 2021: 1 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 8 · 2013: 4 · 2012: 3
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- dietary nitrite, sodium nitrite, hypobaric hypoxia, oxidative stress, antioxidant genes, cardioprotection, HIF-1α stability, NO/cGMP signaling, cardiac transcriptome, inflammation, heart
- MeSH terms
- Animals, Hypoxia, Antioxidants, Gene Expression Regulation, Cyclic GMP, Heart, Male, Myocardium, Nitric Oxide, Nitrites, Signal Transduction, Rats, Sprague-Dawley, Oxidative Stress, Dietary Supplements, Rats, Hypoxia-Inducible Factor 1, alpha Subunit, Nitric Oxide Synthase Type III, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
