Myocardial protection by nitrite

Calvert, J. W.; Lefer, D. J.

doi:10.1093/cvr/cvp079

Cited by 82Cardiac Ischemia and ReperfusionNitric Oxide and Endothelin EffectsNeurological Disorders and Treatments

Myocardial protection by nitrite

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Calvert, J. W., Lefer, D. J.·2009·Cardiovascular Research

DOI 10.1093/cvr/cvp079PMC PMC2701719

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Abstract

Nitrite has long been considered to be an inert oxidative metabolite of nitric oxide (NO). Recent work, however, has demonstrated that nitrite represents an important tissue storage form of NO that can be reduced to NO during ischaemic or hypoxic events. This exciting series of discoveries has created an entirely new field of research that involves the investigation of the molecular, biochemical, and physiological activities of nitrite under a variety of physiological and pathophysiological states. This has also led to a re-evaluation of the role that nitrite plays in health and disease. As a result there has been an interest in the use of nitrite as a therapeutic strategy for the treatment of acute myocardial infarction. Nitrite therapy has now been studied in several animal models and has proven to be an effective means to reduce myocardial ischaemia-reperfusion injury. This review article will provide a brief summary of the key findings that have led to the re-evaluation of nitrite and highlight the evidence supporting the cardioprotective actions of nitrite and also highlight the potential clinical application of nitrite therapy to cardiovascular diseases.

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Another possible cytoprotective effect of nitrite may be mediated by S-nitrosylation effects on intracellular Ca2+ handling, which decreases Ca2+ entry by inhibiting L-type Ca2+ channels and increases sarcoendoplasmic reticulum Ca2+ uptake by activating SERCA2a.
“Another possible cytoprotective effects of nitrite may be mediated by the effects of S-nitrosylation on the intracellular Ca2+ handling, which decreases Ca2+ entry by inhibiting L-type Ca2+ channels and increasing the sarcoendoplasmic reticulum (SR) Ca2+ uptake by activating SR Ca2+ transport ATPase (SERCA2a) [102].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [102]

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Baker, J. E., Su, J., Fu, X., Hsu, A., Gross, G. J., Tweddell, J. S., & Hogg, N. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.07.057 · Cited by 137 · see citing works
Nitrite is an alternative source of NO in vivo
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NO-synthase and nitrite-reductase components of nitric oxide cycle.
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Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice
Palazzo, A. J., Jones, S. P., Girod, W. G., Anderson, D. C., Granger, D. N., & Lefer, D. J. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.6.h2300 · Cited by 116 · see citing works
Plasma Nitroso Compounds Are Decreased in Patients With Endothelial Dysfunction
Heiß, C., Lauer, T., Dejam, A., Kleinbongard, P., Hamada, S., Rassaf, T., Matern, S., Feelisch, M., & Kelm, M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.089 · Cited by 115 · see citing works
Nitric Oxide Modulates Mitochondrial Respiration in Failing Human Heart
Loke, K. E., Laycock, S. K., Mital, S. R., Wolin, M. S., Bernstein, R. D., Oz, M. C., Addonizio, L. J., Kaley, G., & Hintze, T. H. (1999) · Circulation · doi:10.1161/01.cir.100.12.1291 · Cited by 107 · see citing works
Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion
Johnson, G., Tsao, P. S., Mulloy, D., & Lefer, A. M. (1990) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13354-5 · Cited by 104 · cited 1× · see citing works
“5– 50 mmol/kg/h) during myocardial ischaemia significantly reduced I/R injury in cats.(57) These studies took advantage of the reducing capacity of the acidified solutions to generate NO from nitrite and in so doing simply created an NO donor.”
Background
Cardiomyocyte-Specific Overexpression of NO Synthase-3 Protects Against Myocardial Ischemia-Reperfusion Injury
Elrod, J. W., Greer, J. J. M., Bryan, N. S., Langston, W., Szot, J. F., Gebregzlabher, H., Janssens, S. P., Feelisch, M., & Lefer, D. J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000224324.52466.e6 · Cited by 98 · see citing works
Enhanced S -Nitroso-Albumin Formation From Inhaled NO During Ischemia/Reperfusion
Ng, E. S. M., Jourd’heuil, D., McCord, J. M., Hernandez, D., Yasui, M., Knight, D., & Kubes, P. (2004) · Circulation Research · doi:10.1161/01.res.0000117771.63140.d6 · Cited by 97 · see citing works
HMG‐CoA reductase inhibition protects the diabetic myocardium from ischemia‐reperfusion injury
Lefer, D. J., Scalia, R. G., Jones, S. P., Sharp, B. R., Hoffmeyer, M. R., Farvid, A., Gibson, M. F., & Lefer, A. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0819fje · Cited by 96 · see citing works
Differential response to myocardial reperfusion injury in eNOS-deficient mice
Sharp, B. R., Jones, S. P., Rimmer, D. M., & Lefer, D. J. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00855.2001 · Cited by 95 · see citing works
Untitled work
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Gene Therapy With Inducible Nitric Oxide Synthase Protects Against Myocardial Infarction via a Cyclooxygenase-2–Dependent Mechanism
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Endothelial Nitric Oxide Synthase Plays an Obligatory Role in the Late Phase of Ischemic Preconditioning by Activating the Protein Kinase Cε–p44/42 Mitogen-Activated Protein Kinase–pSer-Signal Transducers and Activators of Transcription1/3 Pathway
Xuan, Y., Guo, Y., Zhu, Y., Wang, O.-L., Rokosh, G. D., & Bolli, R. (2007) · Circulation · doi:10.1161/circulationaha.107.689471 · Cited by 78 · see citing works
Cardioprotection in females: a role for nitric oxide and altered gene expression
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Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine
Troncy, É., Francoeur, M., Salazkin, I., Yang, F., Charbonneau, M., Leclerc, G., Vinay, P., & Blaise, G. A. (1997) · British Journal of Anaesthesia · doi:10.1093/bja/79.5.631 · Cited by 76 · see citing works
Improved Monte Carlo method for ion transport in ion-molecule asymmetric systems at high electric fields
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Noninvasive Determination of Spatially Resolved and Time-Resolved Tissue Perfusion in Humans During Nitric Oxide Inhibition and Inhalation by Use of a Visible-Reflectance Hyperspectral Imaging Technique
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Beneficial effects of SPM-5185, a cysteine-containing NO donor in myocardial ischemia-reperfusion
Siegfried, M. R., Carey, C. M., Ma, X. L., & Lefer, A. M. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.3.h771 · Cited by 75 · see citing works
S-Nitrosohemoglobin in the Fetal Circulation May Represent a Cycle for Blood Pressure Regulation
Funai, E. F., Davidson, A., Seligman, S. P., & Finlay, T. H. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7565 · Cited by 74 · see citing works
Sildenafil-mediated acute cardioprotection is independent of the NO/cGMP pathway
Elrod, J. W., Greer, J. J. M., & Lefer, D. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00306.2006 · Cited by 69 · see citing works
Endothelial dysfunction in the coronary microcirculation: a new clinical entity or an experimental finding?
Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116156 · Cited by 65 · see citing works
Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury.
Lefer, A. M., Xl, M., Weyrich, A. S., & Dj, L. (1993) · PubMed · Cited by 57 · see citing works
Nitrite metabolism by skeletal muscle mitochondria in relation to haem pigments
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Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation
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Inhaled NO impacts vascular but not extravascular compartments in postischemic peripheral organs
Kubes, P., Payne, D., Grisham, M. B., Jourd’heuil, D., & Fox‐Robichaud, A. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h676 · Cited by 47 · see citing works
Myocardial Protection by Nitrite: Evidence That This Reperfusion Therapeutic Will Not Be Lost in Translation
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Role of S-nitrosothiol transport in the cardioprotective effects of S-nitrosocysteine in rat hearts
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Roles of cGMP/cGMP-dependent protein kinase in platelet activation
Walter, U., & Gambaryan, S. P. (2004) · Blood · doi:10.1182/blood-2004-06-2389 · Cited by 33 · see citing works
Nitrite therapy for protection against ischemia-reperfusion injury
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Evidence for in vivo transport of bioactive nitric oxide in human plasma
Rassaf, T., Preik, M., Kleinbongard, P., Lauer, T., Heiß, C., Strauer, B. E., Feelisch, M., & Kelm, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200214995 · Cited by 30 · see citing works
Myocardial protective actions of nitric oxide donors after myocardial ischemia and reperfusion.
Lefer, D. J. (1995) · PubMed · Cited by 29 · see citing works
Cardiopulmonary effects of inhaled nitric oxide in normal dogs and during E. coli pneumonia and sepsis
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Exogenous nitric oxide triggers classic ischemic preconditioning by preventing intracellular Ca2+ overload in cardiomyocytes
Rickover, O., Zinman, T., Kaplan, D., & Shainberg, A. (2007) · Cell Calcium · doi:10.1016/j.ceca.2007.06.003 · Cited by 25 · see citing works
[Nitrate and nitrite reductase activity of milk xanthine oxidase].
Alikulov, Z. A., Np, L., & Vl, K. (1980) · PubMed · Cited by 25 · see citing works
Sildenafil-induced cardioprotection in rabbits
Kukreja, R. C. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.002 · Cited by 24 · see citing works
Hepatobiliary & Pancreatic Diseases International (HBPD INT)
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Statin therapy and myocardial no‐reflow
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Anti-ischemic effects of sildenafil, vardenafil and tadalafil in heart
Kukreja, R. C., Salloum, F. N., & Xi, L. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901533 · Cited by 15 · see citing works
Commentaries on this month's Controversy articles
Lefer, D. J., & Lefer, A. M. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.12.2282b · Cited by 6 · see citing works
Cardiovascular effects of sildenafil in experimental ischemia–reperfusion (reply to “Sildenafil-induced cardioprotection in rabbits, by Kukreja, R.C., Ockaili, R., Salloum, F., Xi, L.”)
Reffelmann, T. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.001 · Cited by 6 · see citing works
Commentaries on this month's Controversy articles
Moore, P. K. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.12.2282a · Cited by 3 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

Becker BF, Heindl B, Kupatt C, Zahler S. Endothelial function and hemos- tasis. Z Kardiol 2000;89:160-167.
Lefer DJ, Lefer AM. Nitric oxide homeostasis control as therapy for car- diovascular diseases. Cardiovasc Res 1993;27:2282.

Sorted by citations

How biology handles nitrite
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases
Zordoky, B. N. M., Robertson, I. M., & Dyck, J. R. B. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.016 · Cited by 340 · see citing works
Novel Insights Into Hydrogen Sulfide–Mediated Cytoprotection
Calvert, J. W., Coetzee, W. A., & Lefer, D. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2882 · Cited by 312 · see citing works
Insulin says NO to cardiovascular disease
Yu, Q., Gao, F., & Ma, X. L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq349 · Cited by 172 · see citing works
Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)
Siddiqi, N., Neil, C., Bruce, M., MacLennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N. H., Lim, P. O., Hildick‐Smith, D., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu096 · Cited by 155 · see citing works
Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms
Brinks, H., Boucher, M., Gao, E., Chuprun, J. K., Pesant, S., Raake, P. W. J., Huang, Z. M., Wang, X., Qiu, G., Gumpert, A. M., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.221010 · Cited by 136 · see citing works
Mediterranean diet and cardioprotection: The role of nitrite, polyunsaturated fatty acids, and polyphenols
Nadtochiy, S. M., & Redman, E. (2011) · Nutrition · doi:10.1016/j.nut.2010.12.006 · Cited by 121 · see citing works
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94 · see citing works
Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases
Maia, L. B., & Moura, J. J. G. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-014-1234-2 · Cited by 86 · see citing works
Nitrite and Nitrite Reductases: From Molecular Mechanisms to Significance in Human Health and Disease
Castiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 79 · see citing works
Ginsenoside Rb1 Preconditioning Enhances eNOS Expression and Attenuates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats
Xia, R., Zhao, B., Wu, Y., Hou, J., Zhang, L., Xu, J., & Xia, Z. (2011) · BioMed Research International · doi:10.1155/2011/767930 · Cited by 74 · see citing works
Clinical translation of nitrite therapy for cardiovascular diseases
Calvert, J. W., & Lefer, D. J. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.001 · Cited by 72 · see citing works
Nitric oxide synthase regulation of cardiac excitation–contraction coupling in health and disease
Simon, J. N., Duglan, D., Casadei, B., & Carnicer, R. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.03.004 · Cited by 72 · see citing works
The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic heart disease
Østergaard, L., Kristiansen, S. B., Angleys, H., Frøkiær, J., Hasenkam, J. M., Jespersen, S. N., & Bøtker, H. E. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0409-x · Cited by 70 · see citing works
Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure—How Strong Is That Link?
Bajić, Z., Šobot, T., Škrbić, R., Stojiljković, M. P., Ponorac, N., Matavulj, A., & Djuric, D. M. (2022) · Biomolecules · doi:10.3390/biom12040536 · Cited by 65 · see citing works
Nitrite in organ protection
Rassaf, T., Ferdinandy, P., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12291 · Cited by 62 · see citing works
Emergent role of gasotransmitters in ischemia-reperfusion injury
Moody, B. F., & Calvert, J. W. (2011) · Medical Gas Research · doi:10.1186/2045-9912-1-3 · Cited by 61 · see citing works
Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy
Vitturi, D. A., & Patel, R. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.037 · Cited by 59 · see citing works
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: The role of endothelial nitric oxide synthase
Lv, L., Shi-sen, J., Xu, J., Gong, J., & Cheng, Y. F. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05628.x · Cited by 59 · see citing works
Nitrite as a mediator of ischemic preconditioning and cytoprotection
Murillo, D., Kamga, C., Mo, L., & Shiva, S. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.01.003 · Cited by 57 · see citing works
Dramatic increase of nitrite levels in hearts of anoxia-exposed crucian carp supporting a role in cardioprotection
Sandvik, G. K., Nilsson, G., & Jensen, F. B. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00538.2011 · Cited by 57 · see citing works
(-)-Epicatechin-induced recovery of mitochondria from simulated diabetes: Potential role of endothelial nitric oxide synthase
Ramírez‐Sánchez, I., Rodríguez, A., Moreno‐Ulloa, A., Ceballos, G. M., & Villarreal, F. J. (2016) · Diabetes and Vascular Disease Research · doi:10.1177/1479164115620982 · Cited by 57 · see citing works
ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway
Chang, L., Wang, Z., Ma, F., Tran, B., Zhong, R. M., Xiong, Y., Dai, T., Wu, J., Xin, X., Guo, W., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6173685 · Cited by 53 · see citing works
On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease
Saijo, F., Milsom, A. B., Bryan, N. S., Bauer, S. M., Vowinkel, T., Ivanovic, M., Andry, C., Granger, D. N., Rodriguez, J., & Feelisch, M. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.009 · Cited by 51 · see citing works
Dietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?
Woessner, M. N., McIlvenna, L. C., Ortiz de Zevallos, J., Neil, C. J., & Allen, J. D. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00414.2017 · Cited by 50 · see citing works
Nitrite and myocardial ischaemia reperfusion injury. Where are we now?
Griffiths, K., Lee, J. J., Frenneaux, M. P., Feelisch, M., & Madhani, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107819 · Cited by 46 · see citing works
Safety and pharmacokinetics of sodium nitrite in patients with subarachnoid hemorrhage: a Phase IIA study
Oldfield, E. H., Loomba, J. J., Monteith, S. J., Crowley, R. W., Medel, R., Gress, D. R., Kassell, N. F., Dumont, A. S., & Sherman, C. R. (2013) · Journal of neurosurgery · doi:10.3171/2013.3.jns13266 · Cited by 42 · see citing works
Neuroprotection by inhaled nitric oxide in a murine stroke model is concentration and duration dependent
Li, Y., Shemmer, B., Stone, E., Nardi, M. A., Jonas, S., & Quartermain, D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.031 · Cited by 42 · see citing works
The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injury
Frantz, S., Adamek, A., Fraccarollo, D., Tillmanns, J., Widder, J. D., Dienesch, C., Schäfer, A., Podolskaya, A. A., Held, M. C., Ruetten, H., et al. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0041-3 · Cited by 41 · see citing works
The Preventive Effects of Diminazene Aceturate in Renal Ischemia/Reperfusion Injury in Male and Female Rats
Malek, M., & Nematbakhsh, M. (2014) · Advances in Preventive Medicine · doi:10.1155/2014/740647 · Cited by 40 · see citing works
Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases
Liu, Y., Croft, K. D., Hodgson, J. M., Mori, T., & Ward, N. C. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.006 · Cited by 41 · see citing works
Dietary nitrite attenuates oxidative stress and activates antioxidant genes in rat heart during hypobaric hypoxia
Singh, M., Arya, A., Kumar, R., Bhargava, K., & Sethy, N. K. (2012) · Nitric Oxide · doi:10.1016/j.niox.2011.12.002 · Cited by 38 · see citing works
A Bioactive Chemical Markers Based Strategy for Quality Assessment of Botanical Drugs: Xuesaitong Injection as a Case Study
Yang, Z., Shao, Q., Ge, Z., Ai, N., Zhao, X., & Fan, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-02305-y · Cited by 36 · see citing works
Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a “2‐Hit” Murine Model
LaPenna, K. B., Li, Z., Doiron, J. E., Sharp, T. E., Xia, H., Moles, K., Koul, K., Wang, J. S., Polhemus, D. J., Goodchild, T. T., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.028480 · Cited by 29 · see citing works
Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction
Rodriguez, C., Vitturi, D. A., He, J., Vandromme, M., Brandon, A., Hutchings, A., Rue, L. W., Kerby, J. D., & Patel, R. P. (2009) · Biochemical Journal · doi:10.1042/bj20090735 · Cited by 31 · see citing works
Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway
Hsu, S., Chang, T., Wu, Y.-K., Lin, K., Shi, L.-S., & Lee, S. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1524-z · Cited by 32 · see citing works
Atorvastatin Protects against Ischemia-Reperfusion Injury in Fructose-Induced Insulin Resistant Rats
Prakash, P., Khanna, V., Singh, V., Jyoti, A., Jain, M. K., Keshari, R. S., Barthwal, M. K., & Dikshit, M. (2011) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-011-6312-x · Cited by 28 · see citing works
Preconditioning via Angiotensin Type 2 Receptor Activation Improves Therapeutic Efficacy of Bone Marrow Mononuclear Cells for Cardiac Repair
Xu, Y., Hu, X., Wang, L., Jiang, Z., Liu, X., Yu, H., Zhang, Z., Chen, H., Chen, H., Steinhoff, G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082997 · Cited by 25 · see citing works
Protective Effects of Shenfu Injection against Myocardial Ischemia–Reperfusion Injury via Activation of eNOS in Rats
Wang, Y., Li, Y., Lin, L., Yang, D., Zhou, K., & Li, Y. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00212 · Cited by 26 · see citing works
Periodic acceleration (pGz) prior to whole body Ischemia reperfusion injury provides early cardioprotective preconditioning
Adams, J. A., Wu, H., Bassuk, J. A., Arias, J., Uryash, A., Jorapur, V., Lamas, G. A., & Kurlansky, P. A. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.02.022 · Cited by 22 · see citing works
Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane
Lenčová-Popelová, O., Jirkovský, E., Jansová, H., Jirkovská, A., Vostatková, L., Mazurová, Y., Adamcová, M., Chládek, J., Hroch, M., Pokorná, Z., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.021 · Cited by 21 · see citing works
Low-Dose Sodium Nitrite Fluid Resuscitation Prevents Lethality From Crush Syndrome by Improving Nitric Oxide Consumption and Preventing Myoglobin Cytotoxicity in Kidney in A Rat Model
Murata, I., Miyake, Y., Takahashi, N., Suzuki, R., Fujiwara, T., Sato, Y., Inoue, Y., Kobayashi, J., & Kanamoto, I. (2016) · Shock · doi:10.1097/shk.0000000000000817 · Cited by 19 · see citing works
Polyphenols in Obesity and Metabolic Syndrome
Pastor‐Villaescusa, B., Rodriguez, E. S., & Rangel-Huerta, Ó. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812504-5.00011-8 · Cited by 18 · see citing works
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Authors: Calvert, J. W., & Lefer, D. J.
Affiliations: Emory University (US)
Corresponding author: Lefer, D. J.
ORCID: Calvert, J. W.
Lefer, D. J.
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2009-02-27
Volume: 83
Issue: 2
Pages: 195-203
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1093/cvr/cvp079
PMC: PMC2701719
OpenAlex: W1978288131
Cited by: 82
References: 119
Citations by year: 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 7
FWCI: 1.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cardiovascular Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Emory University
National Institutes of Health
National Heart, Lung, and Blood Institute (2R01HL-060849-09, R01HL060849)
National Institute of Diabetes and Digestive and Kidney Diseases (F32DK077380)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords: nitrite, cardioprotection, nitric oxide, nitrite therapy, acute myocardial infarction, myocardial ischemia-reperfusion injury, hypoxia, oxidative metabolism, cardiovascular disease
MeSH terms: Animals, Homeostasis, Humans, Myocardial Infarction, Myocardium, Nitric Oxide, Nitrites, Risk Factors, Myocardial Reperfusion Injury, Treatment Outcome, Cytoprotection

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