Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice
Open accessAbstract
Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-кB), which are present before the neuronal activity induced by training. It was proposed that the activation of these types of TFs allows a second step in gene regulation by induction of immediate-early genes (IEGs) whose protein products are, in turn, TFs. Between these IEGs, zif268 has been found to play a critical role in long-term memory formation and reprocessing after retrieval. Here we found in mice hippocampus that, on one hand, NF-кB was activated 45 min after training in a novel object recognition (NOR) task and that inhibiting NF-кB immediately after training by intrahippocampal administration of NF-кB Decoy DNA impaired NOR memory consolidation. On the other hand, Zif268 protein expression was induced 45 min after NOR training and the administration of DNA antisense to its mRNA post-training impaired recognition memory. Finally, we found that the inhibition of NF-кB by NF-кB Decoy DNA reduced significantly the training-induced Zif268 increment, indicating that NF-кB is involved in the regulation of Zif268 expression. Thus, the present results support the involvement of NF-кB activity-dependent Zif268 expression in the hippocampus during recognition memory consolidation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Expression of NF-kB and the immediate-early gene zif268 were increased after object exploration, and post-trial intra-hippocampal inhibition of NF-kB or zif268 impaired NOP memory.
“Expression of the nuclear factor kappa B (NF-kB) and the immediate-early gene zif268 were increased after object exploration, and post-trial intra-hippocampal inhibition of NF-kB or zif268 impaired NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Zalcman et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I
Glowinski, J., & Iversen, L. L. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb09873.x · Cited by 5,436 · see citing works
Cole, A. J., Saffen, D. W., Baraban, J. M., & Worley, P. F. (1989) · Nature · doi:10.1038/340474a0 · Cited by 1,010 · see citing works
Transcription Factors in Long-Term Memory and Synaptic Plasticity
Alberini, C. M. (2009) · Physiological Reviews · doi:10.1152/physrev.00017.2008 · Cited by 991 · see citing works
Jones, M. W., Errington, M. L., French, P. J., Fine, A., Bliss, T., Garel, S., Charnay, P., Bozon, B., Laroche, S., & Davis, S. (2001) · Nature Neuroscience · doi:10.1038/85138 · Cited by 899 · see citing works
Guzowski, J. F., Setlow, B., Wagner, E. K., & McGaugh, J. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05089.2001 · Cited by 700 · see citing works
NF-κB functions in synaptic signaling and behavior
Meffert, M. K., Chang, J. M., Wiltgen, B. J., Fanselow, M. S., & Baltimore, D. (2003) · Nature Neuroscience · doi:10.1038/nn1110 · Cited by 690 · see citing works
Differential expression of immediate early genes in the hippocampus and spinal cord
Wisden, W., Errington, M. L., Williams, S., Dunnett, S. B., Waters, C. M., Hitchcock, D., Evan, G. I., Bliss, T., & Hunt, S. P. (1990) · Neuron · doi:10.1016/0896-6273(90)90118-y · Cited by 674 · see citing works
Rapid and selective induction of BDNF expression in the hippocampus during contextual learning
Hall, J., Thomas, K. L., & Everitt, B. J. (2000) · Nature Neuroscience · doi:10.1038/75698 · Cited by 622 · see citing works
Activation of immediate early genes and memory formation
Tischmeyer, W., & Grimm, R. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050315 · Cited by 422 · see citing works
Guzowski, J. F. (2002) · Hippocampus · doi:10.1002/hipo.10010 · Cited by 392 · see citing works
The Ubiquitin Proteasome System Acutely Regulates Presynaptic Protein Turnover and Synaptic Efficacy
Speese, S. D., Trotta, N., Rodesch, C. K., Aravamudan, B., & Broadie, K. S. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00338-5 · Cited by 236 · see citing works
The IκB Kinase Regulates Chromatin Structure during Reconsolidation of Conditioned Fear Memories
Lubin, F. D., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.039 · Cited by 234 · see citing works
The Transcription Factor Zif268/Egr1, Brain Plasticity, and Memory
Veyrac, A., Besnard, A., Caboche, J., Davis, S., & Laroche, S. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-420170-5.00004-0 · Cited by 184 · see citing works
Jarome, T. J., Werner, C. T., Kwapis, J. L., & Helmstetter, F. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024349 · Cited by 182 · see citing works
Bozon, B., Davis, S., & Laroche, S. (2002) · Hippocampus · doi:10.1002/hipo.10100 · Cited by 172 · see citing works
Juo, P., & Kaplan, J. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.010 · Cited by 164 · see citing works
Katche, C., Bekinschtein, P., Slipczuk, L. N., Goldin, A. P., Izquierdo, I., Cammarota, M., & Medina, J. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912931107 · Cited by 152 · see citing works
NF‐κB/Egr‐1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death
Thyss, R., Virolle, V., Imbert, V., Peyron, J., Aberdam, D., & Virolle, T. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600501 · Cited by 151 · see citing works
Lamprecht, R., & Dudai, Y. (1996) · Learning & Memory · doi:10.1101/lm.3.1.31 · Cited by 149 · see citing works
Ahn, H. J., Hernandez, C. M., Levenson, J. M., Lubin, F. D., Liou, H.-C., & Sweatt, J. D. (2008) · Learning & Memory · doi:10.1101/lm.866408 · Cited by 144 · see citing works
A Role of Fos Expression in the CA3 Region of the Hippocampus in Spatial Memory Formation in Rats
He, J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00332-3 · Cited by 133 · see citing works
Malkani, S., & Rosen, J. B. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00058-0 · Cited by 120 · see citing works
Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation
Gräff, J., Woldemichael, B. T., Berchtold, D., Dewarrat, G., & Mansuy, I. M. (2012) · Nature Communications · doi:10.1038/ncomms1997 · Cited by 119 · see citing works
Neurite Outgrowth in PC12 Cells
Obin, M. S., Mesco, E. R., Gong, X., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11789 · Cited by 102 · see citing works
A Requirement of Nuclear Factor-κB Activation in Fear-potentiated Startle
Yeh, S.-H., Lin, C.-H., Lee, C.-F., & Gean, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206258200 · Cited by 99 · see citing works
Maddox, S. A., Monsey, M. S., & Schafe, G. E. (2010) · Learning & Memory · doi:10.1101/lm.1980211 · Cited by 99 · see citing works
NF‐κB transcription factor is required for inhibitory avoidance long‐term memory in mice
Freudenthal, R., Boccia, M. M., Acosta, G. B., Blake, M. G., Merlo, E., Baratti, C. M., & Romano, A. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04126.x · Cited by 98 · see citing works
Self-citationRegulation of the neuronal proteasome by Zif268 (Egr1)
James, A. B., Conway, A.-M., & Morris, B. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4199-05.2006 · Cited by 94 · see citing works
de la Fuente, V., Freudenthal, R., & Romano, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6066-10.2011 · Cited by 94 · see citing works
Self-citationActivation of Hippocampal Nuclear Factor-κB by Retrieval Is Required for Memory Reconsolidation
Boccia, M. M., Freudenthal, R., Blake, M. G., de la Fuente, V., Acosta, G. B., Baratti, C. M., & Romano, A. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4430-07.2007 · Cited by 87 · see citing works
Self-citationRoles for NF-κB and Gene Targets of NF-κB in Synaptic Plasticity, Memory, and Navigation
Snow, W. M., Stoesz, B. M., Kelly, D. M., & Albensi, B. C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8555-y · Cited by 86 · see citing works
Role of nuclear factor kappaB in the central nervous system.
Małek, R., Borowicz, K. K., Jargiello, M., & Czuczwar, S. J. (2007) · PubMed · Cited by 82 · see citing works
Federman, N., de la Fuente, V., Zalcman, G., Corbi, N., Onori, A., Passananti, C., & Romano, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4181-12.2013 · Cited by 73 · see citing works
Self-citationSoule, J. D., Penke, Z., Kanhema, T., Alme, M. N., Laroche, S., & Bramham, C. R. (2008) · Neural Plasticity · doi:10.1155/2008/269097 · Cited by 66 · see citing works
Maintenance of long-term memory storage is dependent on late posttraining Egr-1 expression
Katche, C., Goldin, A. P., González, M. C., Bekinschtein, P., & Medina, J. H. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.08.001 · Cited by 42 · see citing works
Shi, W., Pun, C., Smith, P. L., & Bunney, B. S. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200002)35:2 · Cited by 41 · see citing works
Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
Merlo, E., & Romano, A. G. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.022 · Cited by 39 · see citing works
Self-citationSol Fustiñana, M., de la Fuente, V., Federman, N., Freudenthal, R., & Romano, A. (2014) · Learning & Memory · doi:10.1101/lm.035998.114 · Cited by 39 · see citing works
Self-citationde la Fuente, V., Federman, N., Fustiñana, M. S., Zalcman, G., & Romano, A. G. (2014) · Hippocampus · doi:10.1002/hipo.22334 · Cited by 30 · see citing works
Self-citationSynaptic Protein Degradation in Memory Reorganization
Kaang, B., & Choi, J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_10 · Cited by 29 · see citing works
Deckmann, K., Rörsch, F., Geißlinger, G., et al. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.09.025 · Cited by 19 · see citing works
Poplawski, S. G., Schoch, H., Wimmer, M. E., Hawk, J. D., Walsh, J. L., Giese, K.-P., & Abel, T. G. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.09.002 · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Romano, A. (2012). NF-rB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction. In B. C. Albensi (Ed.), Transcription factors CREB and NF-rb: Involvement in synaptic plasticity and memory formation. Bentham e-books, p. 97-112.
Cited by
Sorted by citations
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Physiological impact of CB1 receptor expression by hippocampal GABAergic interneurons
Albayram, Ö., Passlick, S., Bilkei-Gorzo, A., Zimmer, A., & Steinhäuser, C. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1782-5 · Cited by 42 · see citing works
Snow, W. M., Cadonic, C., Cortes-Perez, C., Roy Chowdhury, S. K., Djordjevic, J., Thomson, E., Bernstein, M. J., Suh, M., Fernyhough, P., & Albensi, B. C. (2018) · Learning & Memory · doi:10.1101/lm.046284.117 · Cited by 31 · see citing works
- Authors
- Zalcman, G., Federman, N., de la Fuente, V., & Romano, A.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Max Planck Society (DE)
- Corresponding author
- Romano, Arturo
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 119
- Pages
- 10-17
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W1996900694
- Cited by
- 23
- References
- 43
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 2
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- Funders
- National Agency of Scientific and Technological Promotion of Argentina (PICT1482, PICT2369)
- National Council of Research (X198)
- University of Buenos Aires
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- NF-κB, Zif268, immediate early genes, hippocampus, recognition memory, memory consolidation, novel object recognition, transcription factor regulation, antisense RNA, long-term memory formation
- MeSH terms
- Animals, Gene Expression Regulation, Hippocampus, Male, Signal Transduction, NF-kappa B, Recognition, Psychology, Mice, Early Growth Response Protein 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
