Transcription Factors in Long-Term Memory and Synaptic Plasticity
Open accessAbstract
Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory formation. Thus, in the last several years, one main interest of molecular neuroscience has been the identification of families of transcription factors that are involved in both of these processes. Transcription is a highly regulated process that involves the combined interaction and function of chromatin and many other proteins, some of which are essential for the basal process of transcription, while others control the selective activation or repression of specific genes. These regulated interactions ultimately allow a sophisticated response to multiple environmental conditions, as well as control of spatial and temporal differences in gene expression. Evidence based on correlative changes in expression, genetic mutations, and targeted molecular inhibition of gene expression have shed light on the function of transcription in both synaptic plasticity and memory formation. This review provides a brief overview of experimental work showing that several families of transcription factors, including CREB, C/EBP, Egr, AP-1, and Rel, have essential functions in both processes. The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
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The model previously used to predict optimal, irregularly spaced protocols that would enhance LTF was extended to represent induction of c/ebp, a transcription factor known to be essential for LTF.
“In this study, the model previously used85 to predict optimal, irregularly spaced protocols that would enhance LTF (FIG. 4a) was extended to represent induction of c/ebp, a transcription factor known to be essential for LTF96.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [96]
LTF and LTP both rely on cooperative gene induction by pCREB and CBP.
“and both rely on cooperative gene induction by pCREB and CBP53,96,99,100.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [96]
Key molecular mechanisms of memory are substantially conserved from simple model organisms such as A. californica to mammals.
“Although these empirical studies were conducted in A. californica, it should be noted that key molecular mechanisms of memory are substantially conserved from simple model organisms such as A. californica to mammals52,96.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [96]
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Cites
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,148 · see citing works
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Shared Principles in NF-κB Signaling
Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,814 · see citing works
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250 · see citing works
The Emotional Brain: The Mysterious Underpinnings of Emotional Life
LeDoux, J. E. (2004) · Medical Entomology and Zoology · Cited by 4,212 · see citing works
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127 · see citing works
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052 · see citing works
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,001 · see citing works
Squire, L. R. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-268330-5.50013-5 · Cited by 1,932 · see citing works
Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800 · see citing works
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663 · see citing works
Protein synthesis and memory: A review.
Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.518 · Cited by 1,505 · see citing works
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462 · see citing works
A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.
Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S. M., Nishio, Y., Nakajima, T., Hirano, T., & Kishimoto, T. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08316.x · Cited by 1,446 · see citing works
The neurosciences. Third study program
(1975) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/s0300-9629(75)80111-3 · Cited by 1,445 · see citing works
CCAAT/enhancer-binding proteins: structure, function and regulation
Ramji, D. P., & Foka, P. (2002) · Biochemical Journal · doi:10.1042/bj20020508 · Cited by 1,401 · see citing works
Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene
Montminy, M., & Bilezikjian, L. M. (1987) · Nature · doi:10.1038/328175a0 · Cited by 1,390 · see citing works
Herdegen, T., & Leah, J. D. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00018-6 · Cited by 1,352 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Transcription regulation and animal diversity
Levine, M., & Tjian, R. (2003) · Nature · doi:10.1038/nature01763 · Cited by 1,309 · see citing works
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
Petrif, F., Giles, R. H., Dauwerse, H. G., Saris, J. J., Hennekam, R. C. M., Masuno, M., Tommerup, N., van Ommen, G.-J. B., Goodman, R. H., Peters, D. J. M., et al. (1995) · Nature · doi:10.1038/376348a0 · Cited by 1,217 · see citing works
Covalent Modification of DNA Regulates Memory Formation
Miller, C. A., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.022 · Cited by 1,180 · see citing works
Ron, D., & Habener, J. F. (1992) · Genes & Development · doi:10.1101/gad.6.3.439 · Cited by 1,156 · see citing works
Bito, H., Deisseroth, K. A., & Tsien, R. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81816-4 · Cited by 1,123 · see citing works
The long and the short of long–term memory—a molecular framework
Goelet, P., Castellucci, V. F., Schacher, S., & Kandel, E. R. (1986) · Nature · doi:10.1038/322419a0 · Cited by 1,041 · see citing works
The general transcription factors of RNA polymerase II.Preprint
Orphanides, G. M., Lagrange, T., & Reinberg, D. (1996) · Genes & Development · doi:10.1101/gad.10.21.2657 · Cited by 1,036 · see citing works
The role of general initiation factors in transcription by RNA polymerase II
ROEDER, R. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10050-5 · Cited by 1,009 · see citing works
Multiple Forms of DNA-dependent RNA Polymerase in Eukaryotic Organisms
Roeder, R. G., & Rutter, W. J. (1969) · Nature · doi:10.1038/224234a0 · Cited by 971 · see citing works
Stimulus-transcription coupling in neurons: role of cellular immediate-early genes
Morgan, J. I., & Curran, T. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90096-9 · Cited by 969 · cited 1× · see citing works
“Several excellent reviews on the different members of the AP-1 family are available (57, 76, 95, 178, 183).”
TRANSCRIPTIONAL REGULATION BY CYCLIC AMP
Montminy, M. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.807 · Cited by 961 · see citing works
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959 · see citing works
The neurosciences : a study program
Quarton, G. C., Melnechuk, T., & Schmitt, F. O. (1967) · Rockefeller University Press eBooks · Cited by 948 · see citing works
Retrieval and reconsolidation: Toward a neurobiology of remembering
Sara, S. J. (2000) · Learning & Memory · doi:10.1101/lm.7.2.73 · Cited by 919 · see citing works
Jones, M. W., Errington, M. L., French, P. J., Fine, A., Bliss, T., Garel, S., Charnay, P., Bozon, B., Laroche, S., & Davis, S. (2001) · Nature Neuroscience · doi:10.1038/85138 · Cited by 899 · see citing works
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works
Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice
Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.021 · Cited by 892 · see citing works
NF-kB: a crucial transcription factor for glial and neuronal cell function
O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 849 · see citing works
Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. G., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 828 · see citing works
CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation
Korzus, E., Rosenfeld, M. G., & Mayford, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.002 · Cited by 823 · see citing works
Hai, T., & Hartman, M. G. (2001) · Gene · doi:10.1016/s0378-1119(01)00551-0 · Cited by 808 · see citing works
Frey, U., Krug, M., Reymann, K. G., & Matthies, H. (1988) · Brain Research · doi:10.1016/0006-8993(88)90008-x · Cited by 806 · see citing works
Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors
Lekstrom-Himes, J., & Xanthopoulos, K. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28545 · Cited by 801 · see citing works
Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769 · see citing works
Epigenetic mechanisms in memory formation
Levenson, J. M., & Sweatt, J. D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1604 · Cited by 767 · see citing works
Principles of Neural Science, 4th ed.
Schultz, S. K. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.662 · Cited by 752 · see citing works
Dash, P. K., Hochner, B., & Kandel, E. R. (1990) · Nature · doi:10.1038/345718a0 · Cited by 747 · see citing works
Guzowski, J. F., Setlow, B., Wagner, E. K., & McGaugh, J. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05089.2001 · Cited by 700 · see citing works
Toward a molecular definition of long-term memory storage
Bailey, C. H., Bartsch, D., & Kandel, E. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13445 · Cited by 691 · see citing works
NF-κB functions in synaptic signaling and behavior
Meffert, M. K., Chang, J. M., Wiltgen, B. J., Fanselow, M. S., & Baltimore, D. (2003) · Nature Neuroscience · doi:10.1038/nn1110 · Cited by 690 · see citing works
Neuronal competition and selection during memory formation
Han, J.-H., Kushner, S. A., Yiu, A. P., Cole, C. J., Matynia, A., Brown, R. A., Neve, R. L., Guzowski, J. F., Silva, A. J., & Josselyn, S. A. (2007) · Science · doi:10.1126/science.1139438 · Cited by 682 · see citing works
Differential expression of immediate early genes in the hippocampus and spinal cord
Wisden, W., Errington, M. L., Williams, S., Dunnett, S. B., Waters, C. M., Hitchcock, D., Evan, G. I., Bliss, T., & Hunt, S. P. (1990) · Neuron · doi:10.1016/0896-6273(90)90118-y · Cited by 674 · see citing works
Rapid and selective induction of BDNF expression in the hippocampus during contextual learning
Hall, J., Thomas, K. L., & Everitt, B. J. (2000) · Nature Neuroscience · doi:10.1038/75698 · Cited by 622 · see citing works
Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus
Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I.-C., Desai, P., Malone, L. M., & Sweatt, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511767200 · Cited by 615 · see citing works
Song presentation induces gene expression in the songbird forebrain.
Mello, C. V., Vicario, D. S., & Clayton, D. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6818 · Cited by 615 · see citing works
The labile nature of consolidation theory
Nader, K., Schafe, G. E., & LeDoux, J. E. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044580 · Cited by 613 · see citing works
Barco, A., Alarcon, J. M., & Kandel, E. (2002) · Cell · doi:10.1016/s0092-8674(02)00657-8 · Cited by 595 · see citing works
Alberini, C. M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.001 · Cited by 594 · see citing works
Self-citationImpey, S., Mark, M., Villacres, E. C., Poser, S., Chavkin, C., & Storm, D. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80120-8 · Cited by 593 · see citing works
Johannessen, M., Delghandi, M. P., & Moens, U. L. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.05.001 · Cited by 592 · see citing works
Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression
Yamamoto, Y., Verma, U. N., Prajapati, S., Kwak, Y.-T., & Gaynor, R. B. (2003) · Nature · doi:10.1038/nature01576 · Cited by 577 · see citing works
Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572 · see citing works
Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery
Hampsey, M. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.465-503.1998 · Cited by 561 · see citing works
Williams, S. C., Cantwell, C. A., & Johnson, P. F. (1991) · Genes & Development · doi:10.1101/gad.5.9.1553 · Cited by 560 · see citing works
Martin, K. C., Michael, D., Rose, J. C., Barad, M., Casadio, A., Zhu, H., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80330-x · Cited by 545 · see citing works
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
Alberini, C. M., Ghirardl, M., Metz, R., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90386-7 · Cited by 523 · see citing works
Self-citationA nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression
Anest, V., Ostrander, J. H., Cogswell, P. C., Steinbrecher, K. A., Strahl, B. D., & Baldwin, A. S. (2003) · Nature · doi:10.1038/nature01648 · Cited by 522 · see citing works
Molecular taxonomy of major neuronal classes in the adult mouse forebrain
Sugino, K., Hempel, C. M., Miller, M. N., Hattox, A. M., Shapiro, P., Wu, C., Huang, Z. J., & Nelson, S. B. (2006) · Nature Neuroscience · doi:10.1038/nn1618 · Cited by 521 · see citing works
CBP and p300: HATs for different occasions
Kalkhoven, E. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.03.045 · Cited by 499 · see citing works
Bernabeu, R., Bevilaqua, L. R., Ardenghi, P. G., Bromberg, E., Schmitz, P. K., Bianchin, M. M., Izquierdo, I., & Medina, J. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7041 · Cited by 499 · see citing works
Guan, Z., Giustetto, M., Lomvardas, S., Kim, J.-H., Miniaci, M. C., Schwartz, J. H., Thanos, D., & Kandel, E. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01074-7 · Cited by 497 · see citing works
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
Abel, T. G., & Zukin, R. S. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.002 · Cited by 495 · see citing works
The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration
Raivich, G., Bohatschek, M., Costa, C. D., Iwata, O., Galiano, M., Hristova, M., Nateri, A. S., Makwana, M., Riera-Sans, L., Wolfer, D. P., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.005 · Cited by 489 · see citing works
Guzowski, J. F., & McGaugh, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2693 · Cited by 481 · see citing works
MEYER, T. E., & Habener, J. F. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-3-269 · Cited by 467 · see citing works
Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., & Kandel, E. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00684-0 · Cited by 464 · see citing works
Rites of Passage of the Engram
Dudai, Y., & Eisenberg, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.003 · Cited by 455 · see citing works
Activation of immediate early genes and memory formation
Tischmeyer, W., & Grimm, R. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050315 · Cited by 422 · see citing works
The consolidation of new but not reactivated memory requires hippocampal C/EBPβ
Taubenfeld, S. M., Milekic, M. H., Monti, B., & Alberini, C. M. (2001) · Nature Neuroscience · doi:10.1038/90520 · Cited by 420 · see citing works
Self-citationExpression Mechanisms Underlying NMDA Receptor‐Dependent Long‐Term Potentiation
Nicoll, R., & Malenka, R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11320.x · Cited by 417 · see citing works
Miller, C. A., Campbell, S. L., & Sweatt, J. D. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.07.016 · Cited by 417 · see citing works
Turner, B. M. (2007) · Nature Cell Biology · doi:10.1038/ncb0107-2 · Cited by 392 · see citing works
Hall, J., Thomas, K. L., & Everitt, B. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02186.2001 · Cited by 381 · see citing works
Initiation of Transcription by RNA Polymerase II: A Multi-step Process
Zawel, L. S., & Reinberg, D. (1993) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60217-2 · Cited by 375 · see citing works
Bartsch, D., Casadio, A., Karl, K. A., Serodio, P., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81752-3 · Cited by 373 · see citing works
A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?
Knapska, E., & Kaczmarek, L. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.007 · Cited by 371 · see citing works
Metz, R., & Ziff, E. B. (1991) · Genes & Development · doi:10.1101/gad.5.10.1754 · Cited by 358 · see citing works
Sonnenberg, J. L., Macgregor-Leon, P. F., Curran, T., & Morgant, J. I. (1989) · Neuron · doi:10.1016/0896-6273(89)90260-2 · Cited by 350 · see citing works
Neuroplasticity Mediated by Altered Gene Expression
McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347 · see citing works
Worley, P. F., Bhat, R., Baraban, J. M., Erickson, C. A., McNaughton, B. L., & Barnes, C. A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04776.1993 · Cited by 346 · see citing works
Mello, C. V., & Clayton, D. F. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06652.1994 · Cited by 344 · see citing works
Wood, M. A., Kaplan, M. P., Park, A., Blanchard, E. J., Oliveira, A. M. M., Lombardi, T. L., & Abel, T. G. (2005) · Learning & Memory · doi:10.1101/lm.86605 · Cited by 333 · see citing works
Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
Sigurdsson, T., Doyère, V., Cain, C. K., & LeDoux, J. E. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.022 · Cited by 325 · see citing works
Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element
Ubeda, M., Wang, X.-Z., Zinszner, H., Wu, I., Habener, J. F., & Ron, D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1479 · Cited by 310 · see citing works
Epigenetic codes in cognition and behaviour
Gräff, J., & Mansuy, I. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.01.021 · Cited by 307 · see citing works
Igaz, L. M., Vianna, M. R. M. R., Medina, J. H., & Izquierdo, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06781.2002 · Cited by 305 · see citing works
Correlations between immediate early gene induction and the persistence of long-term potentiation
Abraham, W. C., Mason, S. E., Demmer, J., Williams, J. M., Richardson, C. L., Tate, W. P., Lawlor, P. A., & Dragunow, M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90369-q · Cited by 303 · see citing works
Physiological functions for brain NF-κB
Meffert, M. K., & Baltimore, D. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.002 · Cited by 292 · see citing works
Schulz, D. J., Goaillard, J.-M., & Marder, E. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705827104 · Cited by 288 · see citing works
Role of the CCAAT Enhancer Binding Proteins (C/EBPs) in Adipocyte Differentiation
Lane, M. D., Tang, Q.-Q., & Jiang, M.-S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1885 · Cited by 281 · see citing works
Davis, S., Bozon, B., & Laroche, S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00421-7 · Cited by 281 · see citing works
Chen, A. Y.-C., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., Cepeda, I. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00501-4 · Cited by 276 · see citing works
Naranjo, J. R., Mellström, B., Achaval, M., & Sassone‐Corsi, P. (1991) · Neuron · doi:10.1016/0896-6273(91)90063-6 · Cited by 274 · see citing works
Frey, U., Frey, S., Schollmeier, F., & Krug, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021179 · Cited by 273 · see citing works
The role of protein synthesis in memory consolidation: Progress amid decades of debate
Hernandez, P. J., & Abel, T. G. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.09.010 · Cited by 264 · see citing works
Lamprecht, R., Hazvi, S., & Dudai, Y. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08443.1997 · Cited by 263 · see citing works
Drug discovery with engineered zinc-finger proteins
Jamieson, A., Miller, J. C., & Pabo, C. (2003) · Nature reviews. Drug discovery · doi:10.1038/nrd1087 · Cited by 263 · see citing works
Localized neuronal activation in the zebra finch brain is related to the strength of song learning
Bolhuis, J. J., Zijlstra, G. G. O., den Boer‐Visser, A. M., & van der Zee, E. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030539097 · Cited by 261 · see citing works
Behaviourally driven gene expression reveals song nuclei in hummingbird brain
Jarvis, E., Ribeiro, S., da Silva, M. D., Ventura, D., Vielliard, J. M. E., & Mello, C. (2000) · Nature · doi:10.1038/35020570 · Cited by 257 · see citing works
The role of immediate early genes in the stabilization of long-term potentiation
Abraham, W. C., Dragunow, M., & Tate, W. P. (1991) · Molecular Neurobiology · doi:10.1007/bf02935553 · Cited by 254 · see citing works
Bredy, T. W., & Barad, M. (2008) · Learning & Memory · doi:10.1101/lm.801108 · Cited by 248 · see citing works
Tsokas, P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0599-05.2005 · Cited by 245 · see citing works
The C/EBP Family of Transcription Factors
Wedel, A., & Lömsziegler-Heitbrock, H. W. (1995) · Immunobiology · doi:10.1016/s0171-2985(11)80541-3 · Cited by 245 · see citing works
Jenkins, R., & Hunt, S. P. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90731-8 · Cited by 245 · see citing works
Chwang, W. B., Arthur, J. S. C., Schumacher, A., & Sweatt, J. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2522-07.2007 · Cited by 239 · see citing works
Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction.
Lattal, K. M., Barrett, R. M., & Wood, M. A. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.5.1125 · Cited by 236 · see citing works
The IκB Kinase Regulates Chromatin Structure during Reconsolidation of Conditioned Fear Memories
Lubin, F. D., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.039 · Cited by 234 · see citing works
Transcriptional regulation by cyclic AMP-responsive factors
Cesare, D. D., & Sassone‐Corsi, P. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)64009-6 · Cited by 232 · see citing works
Bittinger, M. A., McWhinnie, E. A., Meltzer, J., Iourgenko, V., Latario, B., Liu, X., Chen, C. H., Song, C., Garza, D., & Labow, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.002 · Cited by 230 · see citing works
Balschun, D., Wolfer, D. P., Gass, P., Mantamadiotis, T., Welzl, H., Schütz, G., Frey, J. U., & Lipp, H.-P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06304.2003 · Cited by 229 · see citing works
Kaltschmidt, B., Ndiaye‐Lobry, D., Körte, M., Pothion, S., Arbibe, L., Prüllage, M., Pfeiffer, J., Lindecke, A., Staiger, V., Israël, A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2936-2946.2006 · Cited by 229 · see citing works
Role of the AP-1 transcription factor c-Jun in developing, adult and injured brain
Raivich, G., & Behrens, A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.03.006 · Cited by 222 · see citing works
Long-Term Potentiation of Thalamocortical Transmission in the Adult Visual CortexIn Vivo
Heynen, A. J., & Bear, M. F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09801.2001 · Cited by 220 · see citing works
Gene expression of the transcription factor NF-κ B in hippocampus: regulation by synaptic activity
Meberg, P. J., Kinney, W. R., Valcourt, E. G., & Routtenberg, A. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00229-l · Cited by 215 · see citing works
Schrem, H., Klempnauer, J. L., & Borlak, J. T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.5 · Cited by 210 · see citing works
Rosen, J. B., Fanselow, M. S., Young, S. L., Sitcoske, M., & Maren, S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00294-7 · Cited by 196 · see citing works
Quevedo, J., Vianna, M. R. M. R., Roesler, R., de Paris, F., Izquierdo, I., & Rose, S. P. R. (1999) · Learning & Memory · doi:10.1101/lm.6.6.600 · Cited by 194 · see citing works
Sangha, S., Scheibenstock, A., & Lukowiak, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-22-08034.2003 · Cited by 190 · see citing works
A role for immediate-early transcription factors in learning and memory
Dragunow, M. (1996) · Behavior Genetics · doi:10.1007/bf02359385 · Cited by 188 · see citing works
Bernabeu, R. (1997) · Medical Entomology and Zoology · Cited by 188 · see citing works
CREB, Synapses and Memory Disorders: Past Progress and Future Challenges
Josselyn, S. A., & Nguyen, P. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/156800705774322058 · Cited by 187 · see citing works
Rapid Rise in Transcription Factor mRNAs in Rat Brain After Electroshock‐Induced Seizures
Cole, A. J., Abu‐Shakra, S., Saffen, D. W., Baraban, J. M., & Worley, P. F. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb05777.x · Cited by 186 · see citing works
Hayward, M. D., Duman, R. S., & Nestler, E. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90872-9 · Cited by 181 · see citing works
AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila
Sanyal, S., Sandstrom, D. J., Hoeffer, C. A., & Ramaswami, M. (2002) · Nature · doi:10.1038/416870a · Cited by 181 · see citing works
Wessel, T. C., JOH, T. H., & Volpe, B. T. (1991) · Brain Research · doi:10.1016/0006-8993(91)90800-b · Cited by 180 · see citing works
Taubenfeld, S. M., Wiig, K. A., Monti, B., Dolan, B., Pollonini, G., & Alberini, C. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00084.2001 · Cited by 179 · see citing works
Self-citationKovács, K. A., Steullet, P., Steinmann, M., Kim, Q., Magistretti, P. J., Halfon, O., & Cardinaux, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607524104 · Cited by 179 · see citing works
Heurteaux, C., Bertaina‐Anglade, V., Widmann, C., & Lazdunski, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9431 · Cited by 179 · see citing works
The role of protein synthesis during the labile phases of memory: Revisiting the skepticism
Alberini, C. M. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.007 · Cited by 178 · see citing works
Self-citationStanciu, M., Radulović, J., & Spiess, J. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00174-7 · Cited by 178 · see citing works
The role of ATF/CREB family members in cell growth, survival and apoptosis
Persengiev, S. P., & Green, M. R. (2003) · APOPTOSIS · doi:10.1023/a:1023633704132 · Cited by 175 · see citing works
Protein synthesis-dependent formation of protein kinase Mzeta in long- term potentiation
Osten, P., Valsamis, L., Harris, A. Z., & Sacktor, T. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02444.1996 · Cited by 173 · see citing works
Bozon, B., Davis, S., & Laroche, S. (2002) · Hippocampus · doi:10.1002/hipo.10100 · Cited by 172 · see citing works
Richardson, C. L., Tate, W. P., Mason, S. E., Lawlor, P. A., Dragunow, M., & Abraham, W. C. (1992) · Brain Research · doi:10.1016/0006-8993(92)90938-6 · Cited by 171 · see citing works
Levenson, J. M., Choi, S., Lee, S.-Y., Cao, Y. A., Ahn, H. J., Worley, K. C., Pizzi, M., Liou, H.-C., & Sweatt, J. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5646-03.2004 · Cited by 171 · see citing works
White, J. D., & Gall, C. M. (1987) · Molecular Brain Research · doi:10.1016/0169-328x(87)90040-4 · Cited by 168 · see citing works
Chapter 27 Chapter Seizures, neuropeptide regulation, and mRNA expression in the hippocampus
Gall, C. M., Lauterborn, J. C., Isackson, P. J., & White, J. D. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)61263-7 · Cited by 165 · see citing works
Schulz, S., Siemer, H., Krug, M., & Höllt, V. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05683.1999 · Cited by 153 · see citing works
Kockel, L., Zeitlinger, J., Staszewski, L. M., Mlodzik, M., & Bohmann, D. (1997) · Genes & Development · doi:10.1101/gad.11.13.1748 · Cited by 152 · see citing works
McBindall—A Better Name for CCAAT/Enhancer Binding Proteins?
McKnight, S. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00543-8 · Cited by 152 · see citing works
Barzilai, A., Kennedy, T. E., Sweatt, J. D., & Kandel, E. R. (1989) · Neuron · doi:10.1016/0896-6273(89)90046-9 · Cited by 150 · see citing works
Sterneck, E., Paylor, R. E., Jackson-Lewis, V. R., Libbey, M., Przedborski, S., Tessarollo, L., Crawley, J. N., & Johnson, P. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10908 · Cited by 150 · see citing works
Lamprecht, R., & Dudai, Y. (1996) · Learning & Memory · doi:10.1101/lm.3.1.31 · Cited by 149 · see citing works
Immediate-early genes, kindling and long-term potentiation
Dragunow, M., Currie, R. W., Faull, R. L. M., Robertson, H. A., & Jansen, K. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80066-1 · Cited by 147 · see citing works
Hippocampal CRE-mediated gene expression is required for contextual memory formation
Athos, J., Impey, S., Pineda, V. V., Chen, X., & Storm, D. R. (2002) · Nature Neuroscience · doi:10.1038/nn951 · Cited by 145 · see citing works
Learning‐induced Increase of Immediate Early Gene Messenger RNA in the Chick Forebrain
Anokhin, K. V., & Rose, S. P. R. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00076.x · Cited by 142 · see citing works
Michael, D., Martin, K. C., Seger, R., Ning, M., Baston, R., & Kandel, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1864 · Cited by 141 · see citing works
Cellular responses to chronic treatment with drugs of abuse.
Nestler, E. J. (1993) · PubMed · Cited by 140 · see citing works
Song‐Induced Gene Expression: A Window on Song Auditory Processing and Perception
Mello, C. V., Velho, T., & Pinaud, R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1298.021 · Cited by 136 · see citing works
Inducible repression of CREB function disrupts amygdala-dependent memory
Josselyn, S. A. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.05.008 · Cited by 136 · see citing works
A molecular correlate of memory and amnesia in the hippocampus
Taubenfeld, S. M., Wiig, K. A., Bear, M. F., & Alberini, C. M. (1999) · Nature Neuroscience · doi:10.1038/7217 · Cited by 135 · see citing works
Self-citationGass, P., Herdegen, T., Bravo, R., & Kiessling, M. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00944.x · Cited by 127 · see citing works
The Role of cAMP Response Element-Binding Protein in Drosophila Long-Term Memory
Perazzona, B., Isabel, G., Préat, T., & Davis, R. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4542-03.2004 · Cited by 126 · see citing works
Protein synthesis inhibition and memory: Formation vs amnesia
Gold, P. E. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.10.006 · Cited by 125 · see citing works
Chronic cocaine‐mediated changes in non‐human primate nucleus accumbens gene expression
Freeman, W. M., Nader, M. A., Nader, S. H., Robertson, D. J., Gioia, L., Mitchell, S. M., Daunais, J. B., Porrino, L. J., Friedman, D. P., & Vrana, K. E. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00252.x · Cited by 122 · see citing works
Malkani, S., & Rosen, J. B. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00058-0 · Cited by 120 · see citing works
Winston, S. M., Hayward, M. D., Nestler, E. J., & Duman, R. S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04892.x · Cited by 119 · see citing works
Jarvis, E. D., Mello, C. V., & Nottebohm, F. (1995) · Learning & Memory · doi:10.1101/lm.2.2.62 · Cited by 119 · see citing works
Retrograde Transport of Transcription Factor NF-κB in Living Neurons
Wellmann, H., Kaltschmidt, B., & Kaltschmidt, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009253200 · Cited by 116 · see citing works
Molecular Mechanisms of Long-Term Potentiation in the Insular CortexIn Vivo
Jones, M. W., French, P. J., Bliss, T. V. P., & Rosenblum, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-j0002.1999 · Cited by 116 · see citing works
Participation of Rel/NF-κB transcription factors in long-term memory in the crab Chasmagnathus
Freudenthal, R., & Romano, A. G. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02358-6 · Cited by 114 · see citing works
Morrow, B. A., Elsworth, J. D., Inglis, F. M., & Roth, R. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05666.1999 · Cited by 114 · see citing works
Herdegen, T., Kummer, W., Fiallos-Estrada, C. E., Leah, J. D., & Bravo, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90237-i · Cited by 112 · see citing works
Ahmed, T., & FREY, J. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.04.018 · Cited by 110 · see citing works
Altered protein synthesis is a trigger for long-term memory formation
Klann, E., & Sweatt, J. D. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.009 · Cited by 109 · see citing works
Kamińska, B., Filipkowski, R. K., Żurkowska, G., et al. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00546.x · Cited by 109 · see citing works
Mikenberg, I., Widera, D., Kaus, A., Kaltschmidt, B., & Kaltschmidt, C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000589 · Cited by 107 · see citing works
Papa, M., Pellicano, M., Welzl, H., & Sadile, A. G. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90299-q · Cited by 107 · see citing works
Merlo, E., Freudenthal, R., Maldonado, H., & Romano, A. G. (2005) · Learning & Memory · doi:10.1101/lm.82705 · Cited by 104 · see citing works
French, P. J., O'Connor, V. M., Jones, M. W., Davis, S., Errington, M. L., Voss, K. L., Truchet, B., Wotjak, C. T., Stean, T., Doyère, V., et al. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01467.x · Cited by 103 · see citing works
Kassed, C. A., Willing, A. E., Garbuzova-Davis, S., Sanberg, P. R., & Pennypacker, K. R. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7967 · Cited by 103 · see citing works
Yamagata, K., Kaufmann, W. E., Lanahan, A. A., Papapavlou, M., Barnes, C. A., Andreasson, K. I., & Worley, P. F. (1994) · Learning & Memory · doi:10.1101/lm.1.2.140 · Cited by 103 · see citing works
Herdegen, T., Tölle, T. R., Bravo, R., Zieglgänsberger, W., & Zimmermann, M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90466-7 · Cited by 102 · see citing works
Genes, nerve cells, and the remembrance of things past
Kandel, E. R. (1989) · Journal of Neuropsychiatry · doi:10.1176/jnp.1.2.103 · Cited by 101 · see citing works
Alberini, C. M. (1999) · Journal of Experimental Biology · doi:10.1242/jeb.202.21.2887 · Cited by 100 · see citing works
Self-citationA Requirement of Nuclear Factor-κB Activation in Fear-potentiated Startle
Yeh, S.-H., Lin, C.-H., Lee, C.-F., & Gean, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206258200 · Cited by 99 · see citing works
Krox20 may play a key role in the stabilization of long-term potentiation
Williams, J. M., Dragunow, M., Lawlor, P. A., et al. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00187-j · Cited by 99 · see citing works
Kassed, C. A., & Herkenham, M. A. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.03.026 · Cited by 99 · see citing works
NF‐κB transcription factor is required for inhibitory avoidance long‐term memory in mice
Freudenthal, R., Boccia, M. M., Acosta, G. B., Blake, M. G., Merlo, E., Baratti, C. M., & Romano, A. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04126.x · Cited by 98 · see citing works
The IκB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus
Merlo, E., Freudenthal, R., & Romano, A. G. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00049-0 · Cited by 97 · see citing works
Tinsley, M. R., Quinn, J. J., & Fanselow, M. S. (2004) · Learning & Memory · doi:10.1101/lm.70204 · Cited by 97 · see citing works
Thomas, K. L., Hall, J., & Everitt, B. J. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02247.x · Cited by 92 · see citing works
Long‐term stability of fear memory depends on the synthesis of protein but not mRNA in the amygdala
Parsons, R. G., Gafford, G. M., Baruch, D. E., Riedner, B. A., & Helmstetter, F. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04723.x · Cited by 92 · see citing works
Freudenthal, R., Locatelli, F. F., Hermitte, G., Maldonado, H., Lafourcade, C., Delorenzi, A., & Romano, A. G. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00059-7 · Cited by 90 · see citing works
Warburton, E. C., Glover, C. P. J., Massey, P. V., Wan, H., Johnson, B., Bienemann, A. S., Deuschle, U., Kew, J. N. C., Aggleton, J. P., Bashir, Z. I., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0506-05.2005 · Cited by 90 · see citing works
Transcription factor NF‐κB activation after in vivo perforant path LTP in mouse hippocampus
Freudenthal, R., Romano, A. G., & Routtenberg, A. (2004) · Hippocampus · doi:10.1002/hipo.20020 · Cited by 88 · see citing works
T HE R OLE OF C/EBP IN N UTRIENT AND H ORMONAL R EGULATION OF G ENE E XPRESSION
Roesler, W. J. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.141 · Cited by 88 · see citing works
A Molecular Switch for the Consolidation of Long‐Term Memory: cAMP‐Inducible Gene Expression
Alberini, C. M., Ghirardi, M., Huang, Y.-Y., Nguyen, P., & Kandel, E. R. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb24833.x · Cited by 87 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- [15]Alberts B Johnson A Lewis J Raff M Roberts K Walter P Chapter 7 Molecular Biology of the Cell 2002 New York Garland Science
- [72]Frey JU Richter D Long-lasting hippocampal plasticity: cellular model from memory consolidation? Cell polarity and subcellular RNA localization Results and problems in cell differentiation 2001 34 Berlin, Heidelberg Springer-Verlag 27 40 11288677
- [223]Squire LR Memory and brain 1987 New York Oxford
- [233]Thiel G Transcription factors in the nervous system 2006 Wiley-VCH
Cited by
Sorted by citations
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711 · see citing works
Self-citationYoung blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works
Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012 · see citing works
HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation
McQuown, S. C., Barrett, R. M., Matheos, D. P., Post, R. J., Rogge, G. A., Alenghat, T., Mullican, S. E., Jones, S., Rusche, J. R., Lazar, M. A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5052-10.2011 · Cited by 507 · see citing works
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
Yang, J., Ruchti, E., Petit, J.-M., Jourdain, P., Grenningloh, G., Allaman, I., & Magistretti, P. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322912111 · Cited by 504 · see citing works
Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434 · see citing works
Genetic and Epigenetic Networks in Intellectual Disabilities
van Bokhoven, H. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132512 · Cited by 382 · see citing works
The Regulation of Transcription in Memory Consolidation
Alberini, C. M., & Kandel, E. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021741 · Cited by 362 · see citing works
Self-citationThe right time to learn: Mechanisms and optimization of spaced learning
Smolen, P., Zhang, Y., & Byrne, J. H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.18 · Cited by 326 · see citing works
Dysfunction of NMDA receptors in Alzheimer’s disease
Zhang, Y., Li, P., Feng, J., & Wu, M. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2546-5 · Cited by 282 · see citing works
“Phosphorylation of CREB at residue ser-133 is particularly important for its transcriptional activity, which is decreased in AD [36].”
BackgroundMemory Retrieval and the Passage of Time: From Reconsolidation and Strengthening to Extinction
Inda, M. C., Muravieva, E. V., & Alberini, C. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4736-10.2011 · Cited by 261 · see citing works
Self-citationBarrett, R. M., Malvaez, M., Kramar, E., Matheos, D. P., Arrizon, A., Cabrera, S. M., Lynch, G., Greene, R. W., & Wood, M. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.61 · Cited by 243 · see citing works
Biochemical Computation for Spine Structural Plasticity
Nishiyama, J., & Yasuda, R. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.043 · Cited by 199 · see citing works
DNA methylation in social insects: how epigenetics can control behavior and longevity
Yan, H., Bonasio, R., Simola, D. F., Liebig, J., Berger, S. L., & Reinberg, D. (2015) · Annual Review of Entomology · doi:10.1146/annurev-ento-010814-020803 · Cited by 183 · see citing works
Epigenetic mechanisms of major depression: Targeting neuronal plasticity
Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works
Regulation of Memory Formation by the Transcription Factor XBP1
Martínez, G., Vidal, R. L., Mardones, P., Serrano, F. G., Ardiles, A. O., Wirth, C., Valdés, P., Thielen, P., Schneider, B. L., Kerr, B., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.028 · Cited by 163 · see citing works
Marco, A., Meharena, H. S., Dileep, V., Raju, R. M., Davila-Velderrain, J., Zhang, A. L., Adaikkan, C., Young, J. Z., Gao, F., Kellis, M., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00717-0 · Cited by 159 · see citing works
A Positive Autoregulatory BDNF Feedback Loop via C/EBPβ Mediates Hippocampal Memory Consolidation
Bambah-Mukku, D., Travaglia, A., Chen, D. Y., Pollonini, G., & Alberini, C. M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0324-14.2014 · Cited by 145 · see citing works
Self-citationShort term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT
Dakic, V., Minardi Nascimento, J., Costa Sartore, R., Maciel, R. D. M., de Araujo, D. B., Ribeiro, S., Martins-de-Souza, D., & Rehen, S. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-12779-5 · Cited by 134 · see citing works
Manipulating a “Cocaine Engram” in Mice
Hsiang, H.-L. (., Epp, J. R., van den Oever, M. C., Yan, C., Rashid, A. J., Insel, N., Ye, L., Niibori, Y., Deisseroth, K., Frankland, P. W., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-14.2014 · Cited by 131 · see citing works
Jefsen, O. H., Elfving, B., Wegener, G., & Müller, H. K. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881120959614 · Cited by 127 · see citing works
HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: Where do we stand?
Whittle, N., & Singewald, N. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130233 · Cited by 117 · see citing works
McNulty, S. E., Barrett, R. M., Vogel-Ciernia, A., Malvaez, M., Hernandez, N., Davatolhagh, M. F., Matheos, D. P., Schiffman, A., & Wood, M. A. (2012) · Learning & Memory · doi:10.1101/lm.026385.112 · Cited by 117 · see citing works
Sustained Effects of Rapidly Acting Antidepressants Require BDNF-Dependent MeCP2 Phosphorylation
Kim, J.-W., Autry, A. E., Na, E. S., Adachi, M., Björkholm, C., Kavalali, E. T., & Monteggia, L. M. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00868-8 · Cited by 113 · see citing works
Ljungberg, M. C., Ali, Y. O., Zhu, J., Wu, C.-S., Oka, K., Zhai, R. G., & Lu, H.-C. (2012) · Human Molecular Genetics · doi:10.1093/hmg/ddr492 · Cited by 107 · see citing works
Regulation of habit formation in the dorsal striatum
Malvaez, M., & Wassum, K. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.11.005 · Cited by 96 · see citing works
de la Fuente, V., Freudenthal, R., & Romano, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6066-10.2011 · Cited by 94 · see citing works
p300/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear
Wei, W., Coelho, C. M., Li, X., Marek, R., Yan, S., Anderson, S., Meyers, D., Mukherjee, C., Sbardella, G., Castellano, S., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0178-12.2012 · Cited by 93 · see citing works
Epigenetic mechanisms in fear conditioning: Implications for treating post-traumatic stress disorder
Kwapis, J. L., & Wood, M. A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.005 · Cited by 87 · see citing works
Computational design of enhanced learning protocols
Zhang, Y., Liu, R.-Y., Heberton, G. A., Smolen, P., Baxter, D. A., Cleary, L. J., & Byrne, J. H. (2012) · Nature Neuroscience · doi:10.1038/nn.2990 · Cited by 80 · see citing works
Federman, N., de la Fuente, V., Zalcman, G., Corbi, N., Onori, A., Passananti, C., & Romano, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4181-12.2013 · Cited by 73 · see citing works
Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism
Pei, L., Mu, Y., Leblanc, M., Alaynick, W., Barish, G. D., Pankratz, M., Tseng, T. W., Kaufman, S., Liddle, C., Yu, R. T., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.004 · Cited by 65 · see citing works
Bridging Rapid and Sustained Antidepressant Effects of Ketamine
Kim, J.-W., Suzuki, K., Kavalali, E. T., & Monteggia, L. M. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.02.003 · Cited by 59 · see citing works
Liu, R.-Y., Cleary, L. J., & Byrne, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5071-10.2011 · Cited by 60 · see citing works
Habits are negatively regulated by histone deacetylase 3 in the dorsal striatum
Malvaez, M., Greenfield, V. Y., Matheos, D. P., Angelillis, N. A., Murphy, M. D., Kennedy, P. J., Wood, M. A., & Wassum, K. M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.025 · Cited by 56 · see citing works
Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction
Perfitt, T. L., Wang, X., Dickerson, M. T., Stephenson, J. R., Nakagawa, T., Jacobson, D. A., & Colbran, R. J. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0893-19.2020 · Cited by 54 · see citing works
Da Silva, W. C., Cardoso, G., Bonini, J. S., Benetti, F., & Izquierdo, I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302356110 · Cited by 52 · see citing works
Sol Fustiñana, M., de la Fuente, V., Federman, N., Freudenthal, R., & Romano, A. (2014) · Learning & Memory · doi:10.1101/lm.035998.114 · Cited by 39 · see citing works
Involvement of hippocampal CAMKII/CREB signaling in the spatial memory retention induced by creatine
Souza, M. A., Magni, D. V., Guerra, G. P., Oliveira, M. S., Furian, A. F., Pereira, L., Marquez, S. V., Ferreira, J., Fighera, M. R., & Royes, L. F. F. (2012) · Amino Acids · doi:10.1007/s00726-012-1329-4 · Cited by 42 · see citing works
Serotonin- and training-induced dynamic regulation of CREB2 in <i>Aplysia</i>
Liu, R.-Y., Shah, S., Cleary, L. J., & Byrne, J. H. (2011) · Learning & Memory · doi:10.1101/lm.2112111 · Cited by 24 · see citing works
Zalcman, G., Federman, N., de la Fuente, V., & Romano, A. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.12.013 · Cited by 23 · see citing works
Jee, S.-C., Lee, K. M., Kim, M., Lee, Y.-J., Kim, S., Park, J.-O., & Sung, J.-S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239202 · Cited by 15 · see citing works
“Activation of CREB is required for the formation and retention of memory, which is the main physiological parameter of AD [54].”
BackgroundQuerfurth, H., Marshall, J., Parang, K., Rioult-Pedotti, M. S., Tiwari, R., Kwon, B., Reisinger, S., & Lee, H.-K. (2022) · PLOS ONE · doi:10.1371/journal.pone.0261696 · Cited by 9 · see citing works
- Authors
- Alberini, C. M.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Alberini, Cristina M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2009-01
- Volume
- 89
- Issue
- 1
- Pages
- 121-145
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC3883056
- OpenAlex
- W2172149172
- Cited by
- 991
- References
- 269
- Citations by year
- 2026: 24 · 2025: 53 · 2024: 48 · 2023: 57 · 2022: 55 · 2021: 63 · 2020: 62 · 2019: 52 · 2018: 69 · 2017: 62 · 2016: 67 · 2015: 57 · 2014: 80 · 2013: 62 · 2012: 56
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01 MH65635, R01-MH-74736, R01MH074736, R01MH065635)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- transcription factors, long-term memory, synaptic plasticity, gene expression regulation, chromatin, CREB, C/EBP, Egr transcription factors, AP-1, Rel transcription factors, memory formation, synaptic changes
- MeSH terms
- Animals, Chromatin, Humans, Memory, Neuronal Plasticity, Synapses, Transcription Factors, Cyclic AMP Response Element-Binding Protein, CCAAT-Enhancer-Binding Proteins, Early Growth Response Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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