The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
The nuclear matrix protein Matr3 regulates processing of the synaptic microRNA-138-5p
Abstract
microRNA-dependent post-transcriptional control represents an important gene-regulatory layer in post-mitotic neuronal development and synaptic plasticity. We recently identified the brain-enriched miR-138 as a negative regulator of dendritic spine morphogenesis in rat hippocampal neurons. A potential involvement of miR-138 in cognition is further supported by a recent GWAS study on memory performance in a cohort of aged (>60 years) individuals. The expression of miR-138, which is encoded in two independent genomic loci (miR-138-1 and -2), is subject to both cell-type and developmental stage-specific regulation, the underlying molecular mechanisms however are poorly understood. Here, we show that miR-138-2 is the primary source of mature miR-138 in developing rat hippocampal neurons. Furthermore, we obtained evidence for the regulation of miR-138-2 biogenesis at the level of primary miRNA processing. Using biochemical pull-down assays, we identified the nuclear matrix protein Matrin-3 as pri/pre-miR-138 interacting protein and mapped the interaction to the pri/pre-miR-138-2 loop region. Matrin-3 loss-of-function experiments in HEK293 cells and primary neurons together with protein localization studies suggest an inhibitory function of Matrin-3 in nuclear pri-miR-138-2 processing. Together, our experiments unravel a new mechanism of miR-138 regulation in neurons, with important implications for miR-138 regulation during neuronal development, synaptic plasticity and memory-rela…
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“It has been described that mir-138-5p increases its expression during neuronal development in vitro [69]”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [69]
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Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
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Self-citationPost-transcriptional regulation of microRNA expression
Obernosterer, G., Leuschner, P. J. F., Alenius, M., & Martinez, J. (2006) · RNA · doi:10.1261/rna.2322506 · Cited by 474
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
ITALSGEN, Johnson, J. O., Pioro, E. P., Boehringer, A., Chia, R., Feit, H., Renton, A. E., Pliner, H. A., Abramzon, Y., Marangi, G., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3688 · Cited by 445
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Self-citationA Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis
Treiber, T., Treiber, N., Plessmann, U., Harlander, S., Daiß, J.-L., Eichner, N., Lehmann, G., Schall, K., Urlaub, H., & Meister, G. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.03.014 · Cited by 302
Self-citationAltered microRNA regulation in Huntington's disease models
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Potent degradation of neuronal miRNAs induced by highly complementary targets
de la Mata, M., Gaidatzis, D., Vitanescu, M., Stadler, M. B., Wentzel, C., Scheiffele, P., Filipowicz, W., & Großhans, H. (2015) · The EMBO Reports · doi:10.15252/embr.201540078 · Cited by 193
Activity-dependent spatially localized miRNA maturation in neuronal dendrites
Sambandan, S., Akbalık, G., Kochen, L., Rinne, J. S., Kahlstatt, J., Glock, C., Tushev, G., Alvarez‐Castelao, B., Heckel, A., & Schuman, E. M. (2017) · Science · doi:10.1126/science.aaf8995 · Cited by 187
Cited by
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
Brennan, G. P., & Henshall, D. C. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0369-8 · Cited by 169
Maza, R. M., Barreda-Manso, M. A., Reigada, D., Silván, Á., Muñoz-Galdeano, T., Soto, A., del Águila, Á., & Nieto-Díaz, M. (2022) · Biomedicines · doi:10.3390/biomedicines10071559 · Cited by 12
Metadata
- Authors
- Weiss, K., Treiber, T., Meister, G., & Schratt, G.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 159
- Pages
- 36-45
- ISSN
- 1074-7427
- Cited by
- 18
- References
- 24
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Funders
- Deutsche Forschungsgemeinschaft (SCHR 1136/8-1)
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- Weiss, K., Treiber, T., Meister, G., & Schratt, G. (2019). The nuclear matrix protein Matr3 regulates processing of the synaptic microRNA-138-5p. Neurobiology of Learning and Memory. https://doi.org/10.1016/j.nlm.2019.02.008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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