Biologic correlation between glucose transporters, hexokinase-II, Ki-67 and FDG uptake in malignant melanoma
Abstract
Introduction The purpose of this study was to investigate the correlative association between tumoral 2-deoxy-2-[(18)F]-fluoro-D-glucose (FDG) uptake, and the expressions of glucose transporter 1 (GLUT-1), glucose transporter 3 (GLUT-3), hexokinase II (HK-2), and Ki-67 expression in malignant melanoma. Methods Nineteen patients with histologically proven malignant melanoma and pretreatment FDG PET/CT performance were involved in this preliminary study. For semi-quantitative analysis of FDG PET/CT, maximal standardized uptake values (SUVmax) were estimated. Immunohistochemical staining of tumor sections was performed for GLUT-1, GLUT-3, and HK-2, and for the cell proliferation maker Ki-67. Especially, by combining proportions and intensity of immunochemical staining, we evaluated modified immunohistologic scores of GLUT-1 and GLUT-3. Results The SUVmax of malignant melanoma lesions ranged from 2 to 18.7 (average; 9.1±5.4). Comparison between nodal and extranodal lesions revealed no significant difference of SUVmax (p=0.97). GLUT-1 staining showed the most positive expression level (89.5%, 17/19) among the diverse immunohistochemical markers. There were significant relationships between FDG uptake of malignant melanoma and GLUT-1 proportion (p Conclusions The data in this preliminary study indicate that FDG uptake in malignant melanoma is determined by GLUT-1 and GLUT-3, whereas HK-2 and Ki-67 play no role in FDG uptake of malignant melanoma.
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[18F]FDG uptake in tumors, inflammatory cells and brain tissue is mainly brought about by insulin-independent glucose transporters GLUT1 or GLUT3.
“[18F]FDG uptake in tumors, inflammatory cells and brain tissue is mainly brought about by insulin-independent glucose transporters (GLUT) 1 or 3 [13,14,15,16,17,18,19].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [16]
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- Authors
- Park, S. G., Lee, J. H., Lee, W. A., & Han, K. M.
- Affiliations
- Dankook University Hospital (KR)
- Corresponding author
- Lee, Jai Hyuen
- Venue
- Nuclear Medicine and Biology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 39
- Issue
- 8
- Pages
- 1167-1172
- ISSN
- 0969-8051 (ISSN-L)
- OpenAlex
- W1972427825
- Cited by
- 51
- References
- 41
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 2 · 2013: 3
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nuclear Medicine and Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dankook University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Keywords
- melanoma, FDG uptake, glucose transporters, GLUT1, GLUT3, hexokinase 2, Ki-67, cell proliferation, FDG PET/CT, SUVmax, immunohistochemistry scoring, tumor glucose metabolism
- MeSH terms
- Adult, Aged, Aged, 80 and over, Hexokinase, Humans, Immunohistochemistry, Male, Melanoma, Middle Aged, Gene Expression Regulation, Neoplastic, Ki-67 Antigen, Fluorodeoxyglucose F18, Glucose Transporter Type 1, Glucose Transporter Type 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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