Correlation of Glut-1 glucose transporter expression with [18F]FDG uptake in non-small cell lung cancer
Abstract
Positron emission tomography (PET) with [(18)F]2-fluoro-2-deoxy-D-glucose (FDG) may show negative results for bronchioloalveolar lung carcinoma. We investigated the correlation of Glut-1 glucose transporter expression with [(18)F]FDG uptake in non-small cell lung cancer. Thirty-two patients with 34 non-small cell lung cancers (7 bronchioloalveolar carcinomas, 23 non-bronchioloalveolar adenocarcinomas, 3 squamous cell carcinomas, and 1 adenosquamous cell carcinoma) were studied. Final diagnoses were established by histology (via thoracotomy) in all patients. [(18)F]FDG PET was performed 40 min after i.v. injection of 185 MBq [(18)F]FDG. For semi-quantitative analysis of [(18)F]FDG uptake, standardized uptake values (SUVs) were calculated. Glut-1 expression was studied in terms of the immunohistochemistry of paraffin sections using anti-Glut-1 antibody to determine the intensity (0-3) of Glut-1 immunoreactivity and percentage of the Glut-1-positive area. Of seven bronchioloalveolar carcinomas, six (85.7%) were negative for the expression of Glut-1, while only one (4.3%) of 23 non-bronchioloalveolar adenocarcinomas was negative (P<0.0001). The percentages of Glut-1-positive area, as well as the SUVs, were significantly lower in bronchioloalveolar carcinomas (n=7) (2.86%±7.56% and 1.25±0.75, respectively) than in non-bronchioloalveolar adenocarcinomas (n=23) (54.83%±25.64%, P<0.0001, and 3.94±1.93, P=0.001, respectively). The degree of cell differentiation correlated with the per…
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[18F]FDG uptake in tumors, inflammatory cells and brain tissue is mainly brought about by insulin-independent glucose transporters GLUT1 or GLUT3.
“[18F]FDG uptake in tumors, inflammatory cells and brain tissue is mainly brought about by insulin-independent glucose transporters (GLUT) 1 or 3 [13,14,15,16,17,18,19].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [14]
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- Authors
- Higashi, K., Ueda, Y., Sakurai, A., MingWang, X., Xu, L., Murakami, M., Seki, H., Oguchi, M., Taki, S., Nambu, Y., Tonami, H., Katsuda, S., & Yamamoto, I.
- Affiliations
- Kanazawa Medical University (JP)
- Corresponding author
- Higashi, Kotaro
- Venue
- European Journal of Nuclear Medicine
- Published
- 2000-10-12
- Volume
- 27
- Issue
- 12
- Pages
- 1778-1785
- ISSN
- 1619-7070 (ISSN-L)
- 0340-6997
- 1619-7089
- OpenAlex
- W1522571942
- Cited by
- 210
- References
- 30
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 11 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 15 · 2012: 11
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- FDG uptake, non-small cell lung cancer, bronchioloalveolar carcinoma, lung adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, standardized uptake value, immunohistochemistry, cell differentiation, tumor glucose metabolism, PET imaging biomarkers
- MeSH terms
- Aged, Aged, 80 and over, Bronchial Neoplasms, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Cell Differentiation, Female, Humans, Immunohistochemistry, Lung Neoplasms, Male, Middle Aged, Monosaccharide Transport Proteins, Tomography, Emission-Computed, Paraffin Embedding, Radiopharmaceuticals, Fluorodeoxyglucose F18, Glucose Transporter Type 1
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