The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Hepatic lipid metabolism and non-alcoholic fatty liver disease
Abstract
Non-alcoholic fatty liver disease (NAFLD) is an increasingly recognized pathology with a high prevalence and a possible evolution to its inflammatory counterpart (non-alcoholic steatohepatitis, or NASH). The pathophysiology of NAFLD and NASH has many links with the metabolic syndrome, sharing a causative factor in insulin resistance. According to a two-hit hypothesis, increased intrahepatic triglyceride accumulation (due to increased synthesis, decreased export, or both) is followed by a second step (or "hit"), which may lead to NASH. The latter likely involves oxidative stress, cytochrome P450 activation, lipid peroxidation, increased inflammatory cytokine production, activation of hepatic stellate cells and apoptosis. However, both "hits" may be caused by the same factors. The aim of this article is to overview the biochemical steps of fat regulation in the liver and the alterations occurring in the pathogenesis of NAFLD and NASH.
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“Excess triglyceride stores are found in livers of patients with nonalcoholic fatty liver disease (129).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [129]
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Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
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Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
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Molecular mediators of hepatic steatosis and liver injury
Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
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Periago, M. J., & García-Alonso, F.-J. (2016) · Nutraceutical science and technology · doi:10.1201/b19490-52
Abomandour, A., Bakr, A. G., ElGhandour, A. M., Elewa, H., Rhman, M. A., & Zalat, Z. (2023) · Research Square · doi:10.21203/rs.3.rs-2551241/v1
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Lean NAFLD: Prevalence, risk factors/pathogenesis, natural history, and treatment
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Metabolic disorders associated with liver dysfunction
Akash, M. S. H., & Rehman, K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36312-2.00007-3
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Protective Effects of Lingonberry Against Cardiovascular Disease and Its Associated Risk Factors
Hewage, S. M., Prashar, S., Karmin, O., & Siow, Y. L. (2026) · Advances in biochemistry in health and disease · doi:10.1007/978-3-032-14441-6_20
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Metadata
- Authors
- Tessari, P., Coracina, A., Cosma, A., & Tiengo, A.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Tessari, P.
- ORCID
- Tessari, P.
- Venue
- Nutrition, Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 19
- Issue
- 4
- Pages
- 291-302
- ISSN
- 0939-4753 (ISSN-L)
- OpenAlex
- W1978723895
- Cited by
- 314
- References
- 128
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 21 · 2023: 10 · 2022: 18 · 2021: 17 · 2020: 19 · 2019: 14 · 2018: 25 · 2017: 15 · 2016: 24 · 2015: 17 · 2014: 28 · 2013: 24 · 2012: 27
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, hepatic lipid metabolism, insulin resistance, metabolic syndrome, two-hit hypothesis, oxidative stress, cytochrome P450 activation, lipid peroxidation, hepatic stellate cells, inflammation, apoptosis, inflammatory cytokines
- MeSH terms
- Animals, Diet, Fatty Acids, Fatty Liver, Humans, Lipolysis, Lipoproteins, Liver, Oxidation-Reduction, Signal Transduction, Lipogenesis, Lipid Metabolism, Adipokines, AMP-Activated Protein Kinases
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