Cited by 314Liver Disease Diagnosis and TreatmentLiver physiology and pathologyLipid metabolism and biosynthesis

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Hepatic lipid metabolism and non-alcoholic fatty liver disease

Tessari, P., Coracina, A., Cosma, A., Tiengo, A.·2009·Nutrition, Metabolism and Cardiovascular Diseases

DOI 10.1016/j.numecd.2008.12.015

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is an increasingly recognized pathology with a high prevalence and a possible evolution to its inflammatory counterpart (non-alcoholic steatohepatitis, or NASH). The pathophysiology of NAFLD and NASH has many links with the metabolic syndrome, sharing a causative factor in insulin resistance. According to a two-hit hypothesis, increased intrahepatic triglyceride accumulation (due to increased synthesis, decreased export, or both) is followed by a second step (or "hit"), which may lead to NASH. The latter likely involves oxidative stress, cytochrome P450 activation, lipid peroxidation, increased inflammatory cytokine production, activation of hepatic stellate cells and apoptosis. However, both "hits" may be caused by the same factors. The aim of this article is to overview the biochemical steps of fat regulation in the liver and the alterations occurring in the pathogenesis of NAFLD and NASH.

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Authors: Tessari, P., Coracina, A., Cosma, A., & Tiengo, A.
Affiliations: University of Padua (IT)
Corresponding author: Tessari, P.
ORCID: Tessari, P.
Venue: Nutrition, Metabolism and Cardiovascular Diseases
Publisher: Elsevier BV
Published: 2009-05
Volume: 19
Issue: 4
Pages: 291-302
ISSN: 0939-4753 (ISSN-L)
DOI: 10.1016/j.numecd.2008.12.015
OpenAlex: W1978723895
Cited by: 314
References: 128
Citations by year: 2026: 4 · 2025: 5 · 2024: 21 · 2023: 10 · 2022: 18 · 2021: 17 · 2020: 19 · 2019: 14 · 2018: 25 · 2017: 15 · 2016: 24 · 2015: 17 · 2014: 28 · 2013: 24 · 2012: 27
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
PubMed (publishedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, hepatic lipid metabolism, insulin resistance, metabolic syndrome, two-hit hypothesis, oxidative stress, cytochrome P450 activation, lipid peroxidation, hepatic stellate cells, inflammation, apoptosis, inflammatory cytokines
MeSH terms: Animals, Diet, Fatty Acids, Fatty Liver, Humans, Lipolysis, Lipoproteins, Liver, Oxidation-Reduction, Signal Transduction, Lipogenesis, Lipid Metabolism, Adipokines, AMP-Activated Protein Kinases

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Hepatic lipid metabolism and non-alcoholic fatty liver disease

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