The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
Medical Comorbidities in Autism: Challenges to Diagnosis and Treatment
Open accessAbstract
Ever since its original description by Leo Kanner in l943, autism has been generally defined by its clinical characteristics and core symptoms that include impaired social skills, isolated areas of interest, and delayed and disordered language. Over time, it has become apparent that autism is a heterogeneous disorder with regard to its clinical presentation, etiology, underlying neurobiology, and degree of severity. As a result, the termed diagnosis of autism spectrum disorders (ASDs) has come into common usage. With advancements in clinical care, there has come the appreciation that many ASD children, adolescents, and adults may have medically relevant disorders that may negatively impact their developmental progress and behavior, but which frequently go undetected. Many of these medical conditions are treatable, often resulting in improved developmental gains and quality of life for the patient and family. In addition, the possibility exists that some of these medical conditions may suggest the presence of important genetic and/or biologic markers, which, if identified, can refine our ability to be more precise in categorizing clinical and genetic subtypes within the autism spectrum.
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“In clinical cases, other neurodevelopmental conditions, psychiatric disorders and somatic disorders are often co-occurring complications [13–15].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [15]
In the citing paper
“A variety of gastrointestinal (GI) issues commonly occur in ASD, including lower GI symptoms (i.e., constipation, diarrhea) and upper GI symptoms (i.e., nausea and vomiting, stomach aches and pains) (2–10), but the etiology is poorly understood.”
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“Non-verbal patients may also demonstrate GI distress as constant eating or drinking, chewing on non-edible objects and abdominal pressure 40.”
From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [40]
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Cites
(1943) · The Nervous child · Cited by 8,870
Autistic disturbances of affective contact.
Kanner, L. (1968) · PubMed · Cited by 2,282
Handbook of Autism and Pervasive Developmental Disorders
(2005) · Wiley eBooks · doi:10.1002/9780470939352 · Cited by 2,262
The Epidemiology of Autism Spectrum Disorders
Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., Mandell, D. S., Miller, L. A., Pinto-Martin, J., Reaven, J., et al. (2007) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.28.021406.144007 · Cited by 1,228
Buie, T., Campbell, D. B., Fuchs, G. J., Furuta, G. T., Levy, J., VandeWater, J., Whitaker, A. H., Atkins, D., Bauman, M. L., Beaudet, A. L., et al. (2010) · Pediatrics · doi:10.1542/peds.2009-1878c · Cited by 872
Self-citationMitochondrial Energetics and Therapeutics
Wallace, D. C., Fan, W., & Procaccio, V. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092314 · Cited by 747
Development in infants with autism spectrum disorders: a prospective study
Landa, R., & Garrett‐Mayer, E. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01531.x · Cited by 730
Richdale, A. L., & Schreck, K. A. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.02.003 · Cited by 708
Prevalence of motor impairment in autism spectrum disorders
Ming, X., Brimacombe, M., & Wagner, G. C. (2007) · Brain and Development · doi:10.1016/j.braindev.2007.03.002 · Cited by 613
Pardo, C. A., & Eberhart, C. G. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00102.x · Cited by 514
Cited by
Sorted by citations
Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
Hyman, S. L., Levy, S. E., Myers, S. M., COUNCIL ON CHILDREN WITH DISABILITIES, S. O. D. A. B. P., Kuo, D. Z., Apkon, S., Davidson, L. F., Ellerbeck, K. A., Foster, J. E. A., Noritz, G. H., et al. (2020) · Pediatrics · doi:10.1542/peds.2019-3447 · Cited by 1,798
The health status of adults on the autism spectrum
Croen, L. A., Zerbo, O., Qian, Y., Massolo, M. L., Rich, S., Sidney, S., & Kripke, C. (2015) · Autism · doi:10.1177/1362361315577517 · Cited by 1,110
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
Masi, A., DeMayo, M. M., Glozier, N., & Guastella, A. J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0100-y · Cited by 987
Zwaigenbaum, L., Bauman, M. L., Choueiri, R., Kasari, C., Carter, A., Granpeesheh, D., Mailloux, Z., Smith Roley, S., Wagner, S., Fein, D., et al. (2015) · Pediatrics · doi:10.1542/peds.2014-3667e · Cited by 856
Self-citationBannister, S. J. (2009) · Cited by 749
Metadata
- Authors
- Bauman, M. L.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Bauman, Margaret L.
- ORCID
- Bauman, Margaret L.
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 7
- Issue
- 3
- Pages
- 320-327
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC5084236
- OpenAlex
- W1987839624
- Cited by
- 372
- References
- 46
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 23 · 2023: 20 · 2022: 30 · 2021: 42 · 2020: 32 · 2019: 36 · 2018: 34 · 2017: 23 · 2016: 20 · 2015: 26 · 2014: 18 · 2013: 17 · 2012: 15
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4789 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neurotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, comorbidities, autism heterogeneity, developmental outcomes, quality of life, genetic markers, autism subtypes
- MeSH terms
- Autistic Disorder, Endocrine System Diseases, Epilepsy, Gastrointestinal Diseases, Humans, Metabolic Diseases, Sleep Wake Disorders, Comorbidity
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