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Cited by 218Drug-Induced Hepatotoxicity and ProtectionAntioxidant Activity and Oxidative StressSeaweed-derived Bioactive Compounds

The DOI matches its Crossref record; 80 of the 83 references it cites were found in a registry or an index.

Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats

Gad, Ahmed S., Khadrawy, Yasser A., El-Nekeety, Aziza A., Mohamed, Sherif R., Hassan, Nabila S., Abdel-Wahhab, Mosaad A.·2011·Nutrition
DOI 10.1016/j.nut.2010.04.002
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Abstract

Objectives The aims of the present study were to evaluate the antioxidant, radical scavenging, and metal-chelating activity of whey protein concentrate (WPC) and Spirulina alone or in combination in vitro and to evaluate their hepatoprotective effects against CCl(4) in vivo.Methods Five concentrations (20, 40, 60, 80, and 100 mg/100 mL) of WPC, Spirulina, and their combination were tested in vitro. In the in vivo study, eight groups of male rats comprised the control group and the groups treated with WPC, Spirulina alone, or in combination with or without CCl(4) were used.Results The in vitro study showed that WPC and Spirulina showed antioxidant, radical scavenging, and metal-chelating activities in dose-dependent manner. The in vivo study showed that both agents succeeded in preventing liver damage induced by CCl(4). This prevention was more pronounced in rats receiving the combination of WPC and Spirulina.Conclusion Whey protein concentrate and Spirulina have free radical scavenging properties and antioxidant activity.

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Research works printed but not linked: 4

  1. Sukkar, 2004, The role of whey protein in antioxidant defense, Riv Ital Nutr Parent Enter, 22, 193
  2. Anema, 1999, Analysis of whey protein denaturation: a comparative study of alternative methods, Milchwissenschaft, 54, 30
  3. Abd El-Baky, 2004, Production of antioxidant by the green alga Dunaliella salina, Int J Agric Biol, 6, 49
  4. Bounous, 2000, Whey protein concentrate (WPC) and glutathione modulation in cancer treatment, Anticancer Res, 20, 4785

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Metadata

Authors
Gad, A. S., Khadrawy, Y. A., El-Nekeety, A. A., Mohamed, S. R., Hassan, N. S., & Abdel-Wahhab, M. A.
Affiliations
National Research Centre (EG)
Corresponding author
Abdel-Wahhab, Mosaad A.
ORCID
Venue
Nutrition
Publisher
Elsevier BV
Published
2011-05
Volume
27
Issue
5
Pages
582-589
ISSN
0899-9007 (ISSN-L)
DOI
10.1016/j.nut.2010.04.002
OpenAlex
W2053062973
Cited by
218
References
83
Citations by year
2026: 6 · 2025: 7 · 2024: 6 · 2023: 23 · 2022: 19 · 2021: 25 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 12 · 2016: 18 · 2015: 18 · 2014: 6 · 2013: 10 · 2012: 11
FWCI
8.08
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords
whey protein concentrate, Spirulina, antioxidant activity, hepatoprotection, free radical scavenging, metal chelating activity, carbon tetrachloride-induced liver injury, combination supplementation, liver injury prevention
MeSH terms
Whey Proteins, Administration, Oral, Animals, Antioxidants, Carbon Tetrachloride, Chelating Agents, Dose-Response Relationship, Drug, Iron, Liver Diseases, Male, Milk Proteins, Lipid Peroxidation, Free Radical Scavengers, Rats, Sprague-Dawley, Oxidative Stress, Rats, Spirulina

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