Cited by 218Drug-Induced Hepatotoxicity and ProtectionAntioxidant Activity and Oxidative StressSeaweed-derived Bioactive Compounds

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Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats

Gad, Ahmed S., Khadrawy, Yasser A., El-Nekeety, Aziza A., Mohamed, Sherif R., Hassan, Nabila S., Abdel-Wahhab, Mosaad A.·2011·Nutrition

DOI 10.1016/j.nut.2010.04.002

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Abstract

Objectives The aims of the present study were to evaluate the antioxidant, radical scavenging, and metal-chelating activity of whey protein concentrate (WPC) and Spirulina alone or in combination in vitro and to evaluate their hepatoprotective effects against CCl(4) in vivo.Methods Five concentrations (20, 40, 60, 80, and 100 mg/100 mL) of WPC, Spirulina, and their combination were tested in vitro. In the in vivo study, eight groups of male rats comprised the control group and the groups treated with WPC, Spirulina alone, or in combination with or without CCl(4) were used.Results The in vitro study showed that WPC and Spirulina showed antioxidant, radical scavenging, and metal-chelating activities in dose-dependent manner. The in vivo study showed that both agents succeeded in preventing liver damage induced by CCl(4). This prevention was more pronounced in rats receiving the combination of WPC and Spirulina.Conclusion Whey protein concentrate and Spirulina have free radical scavenging properties and antioxidant activity.

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Authors: Gad, A. S., Khadrawy, Y. A., El-Nekeety, A. A., Mohamed, S. R., Hassan, N. S., & Abdel-Wahhab, M. A.
Affiliations: National Research Centre (EG)
Corresponding author: Abdel-Wahhab, Mosaad A.
ORCID: Gad, Ahmed S.
Khadrawy, Yasser A.
Hassan, Nabila S.
Abdel-Wahhab, Mosaad A.
Venue: Nutrition
Publisher: Elsevier BV
Published: 2011-05
Volume: 27
Issue: 5
Pages: 582-589
ISSN: 0899-9007 (ISSN-L)
DOI: 10.1016/j.nut.2010.04.002
OpenAlex: W2053062973
Cited by: 218
References: 83
Citations by year: 2026: 6 · 2025: 7 · 2024: 6 · 2023: 23 · 2022: 19 · 2021: 25 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 12 · 2016: 18 · 2015: 18 · 2014: 6 · 2013: 10 · 2012: 11
FWCI: 8.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords: whey protein concentrate, Spirulina, antioxidant activity, hepatoprotection, free radical scavenging, metal chelating activity, carbon tetrachloride-induced liver injury, combination supplementation, liver injury prevention
MeSH terms: Whey Proteins, Administration, Oral, Animals, Antioxidants, Carbon Tetrachloride, Chelating Agents, Dose-Response Relationship, Drug, Iron, Liver Diseases, Male, Milk Proteins, Lipid Peroxidation, Free Radical Scavengers, Rats, Sprague-Dawley, Oxidative Stress, Rats, Spirulina

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Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats

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