Role of beta-2 adrenergic receptor polymorphism (rs1042714) on body weight and glucose metabolism response to a meal-replacement hypocaloric diet
Open accessAbstract
The beta-2 adrenergic receptor (ADRB2) is involved in energy balance regulation. The objective of our study was to evaluate the role of the rs1042714 genetic variant of ADRB2 gene on weight loss, body composition, and metabolic changes secondary to partial meal replacement (pMR) hypocaloric diet in women with obesity. We conducted an interventional study in 95 premenopausal women with body mass index ≥ 35 kg/m2. The subjects received two intakes per day of a normocaloric hyperproteic formula during 12 wk of a pMR diet. Body weight, body mass index, fat mass, waist circumference, lipid profile, fasting insulin levels, and homeostasis model assessment for insulin resistance were determined. All patients were genotyped rs1042714 and evaluated in a dominant model (CC versus CG + GG). Genotype frequencies were 31 (37.3%), 38 (45.8%), and 14 (16.9%) for the CC, CG, and GG genotypes, respectively. We found significant interaction effects between ADRB2 variant and pMR-induced changes (CC versus CG + GG) on body weight (–7.1 ± 0.3 versus –13.5 ± 0.5 kg; P = 0.03), body mass index (–0.9 ± 0.1 versus –1.2 ± 0.2 kg/m2; P = 0.03), fat mass (–4.9 ± 0.5 versus –10.2 ±1.2 kg; P = 0.01), waist circumference (–5.1 ± 0.2 versus –10.1 ± 1.9 cm; P = 0.03), glucose (–5.1 ± 1.3 versus –12.5 ± 2.5 mg/dL; P = 0.03), total cholesterol (–18.1 ± 9.3 versus –33.5 ± 4.5 mg/dL; P = 0.03), low-density lipoprotein cholesterol (–9.1 ± 5.3 versus –24.5 ± 4.1 mg/dL; P = 0.04), triacylglycerol levels (–6.1 ± 5.3 versus –31.5 ± 9.5 mg/dL; P = 0.04), fasting insulin levels (–1.8 ± 0.3 versus –6.3 ± 0.5 IU/L; P = 0.03), and homeostasis model assessment for insulin resistance (–0.6 ± 0.3 versus –1.9 ± 0.5 U; P = 0.03). The odds ratio to improve alteration in glucose metabolism adjusted by age and weight loss throughout the study was 0.26 (95% CI, 0.07–0.95; P = 0.02) in G allele carriers. The G allele of rs1042714 predicts the magnitude of weight loss resulting from a pMR diet. These adiposity improvements produce a better improvement of insulin resistance and percentage of impaired glucose metabolism in G allele carriers.
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Individuals with heightened β-adrenergic sensitivity experience faster lipolysis, mobilizing fat stores more efficiently during restriction, whereas those with reduced sensitivity may struggle to achieve the same level of fat oxidation.
“Individuals with heightened β-adrenergic sensitivity experience faster lipolysis, mobilizing fat stores more efficiently during restriction, whereas those with reduced receptor sensitivity may struggle to achieve the same level of fat oxidation.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [70]
Genetic differences in β2- and β3-adrenergic receptors affect receptor responsiveness, modulating the rate at which stored triglycerides are hydrolyzed into FFAs.
“Genetic differences in β2-adrenergic receptor and β3-adrenergic receptor affect receptor responsiveness, modulating the rate at which stored triglycerides are hydrolyzed into FFAs.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [70]
The rate of lipolysis in adipose tissue during caloric restriction depends on sensitivity of β-adrenergic receptors to catecholamines like norepinephrine.
“The rate of lipolysis in adipose tissue during caloric restriction depends on the sensitivity of β-adrenergic receptors to catecholamines like norepinephrine.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [70]
β2-adrenergic receptor Arg16Gly and Gln27Glu polymorphisms alter β2-adrenergic receptor sensitivity, impacting lipolytic response to catecholamines.
“The β2-adrenergic receptor Arg16Gly and Gln27Glu polymorphisms alter β2-adrenergic receptor sensitivity, impacting lipolytic response to catecholamines.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [70]
Individuals with high β-adrenergic sensitivity mobilize fat stores more effectively, supporting greater fat loss.
“Individuals with high β-adrenergic sensitivity mobilize fat stores more effectively, supporting greater fat loss [70,71].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [70]
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- Authors
- de Luis, D. A., Izaola, O., Primo, D., & Gómez, J. J. L.
- Affiliations
- Universidad de Valladolid (ES)
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2023-12
- Volume
- 116
- Pages
- 112170
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W4385163422
- Cited by
- 9
- References
- 24
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nutrition (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Hispana (publishedVersion, cc-by)
- University of Valladolid Documentary Repository (University of Valladolid) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- beta2-adrenergic receptor, ADRB2, rs1042714, genetic polymorphism, meal replacement, hypocaloric diet, obesity, weight loss, body composition, fat mass, waist circumference, glucose metabolism, insulin resistance, premenopausal women, lipid profile, fasting insulin, energy balance, gene-diet interaction
- MeSH terms
- Body Weight, Diet, Reducing, Female, Genotype, Glucose, Humans, Insulin Resistance, Cholesterol, LDL, Obesity, Weight Loss, Receptors, Adrenergic, beta-2, Polymorphism, Single Nucleotide, Insulins
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