Fetal hormones and sexual differentiation

Sobel, Vivian; Zhu, Yuan-Shan; Imperato-McGinley, Julianne

doi:10.1016/j.ogc.2004.08.005

Cited by 44Sexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesUrological Disorders and Treatments

Fetal hormones and sexual differentiation

Sobel, Vivian, Zhu, Yuan-Shan, Imperato-McGinley, Julianne·2004·Obstetrics and Gynecology Clinics of North America

DOI 10.1016/j.ogc.2004.08.005

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Abstract

The process of fetal sexual differentiation, which involves establishment of genetic sex, differentiation of the gonads, and development of phenotypic sex, is summarized. The morphologic changes that occur in utero that lead to development of the male and female gonads, germ cells, reproductive tracts, and external genitalia are described. Most of the article focuses on the hormones that regulate sexual differentiation and development in utero. The genetic factors that regulate sexual differentiation, which constitute a new and emerging field, also are discussed.

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Fetal testicular T is essential for the development of the male internal genitalia, while the local conversion of testicular T to DHT is essential for the development of external genitalia taking place between 8 and 12 weeks of gestation.
“Fetal testicular T is essential for the development of the male internal genitalia, while the local conversion of testicular T to DHT is essential for the development of external genitalia taking place between 8 and 12 weeks of gestation (Krone et al., 2007, Sobel et al., 2004).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Sobel et al., 2004

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Authors: Sobel, V., Zhu, Y.-S., & Imperato-McGinley, J.
Affiliations: Cornell University (US)
ORCID: Zhu, Yuan-Shan
Venue: Obstetrics and Gynecology Clinics of North America
Publisher: Elsevier BV
Published: 2004-12
Volume: 31
Issue: 4
Pages: 837-856
ISSN: 0889-8545 (ISSN-L)
DOI: 10.1016/j.ogc.2004.08.005
OpenAlex: W2011408670
Cited by: 44
References: 129
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 2 · 2015: 1 · 2014: 1 · 2012: 4
FWCI: 0.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Obstetrics and Gynecology Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords: sex determination, gonadal differentiation, external genitalia development, reproductive tract development, germ cells, fetal hormones, phenotypic sex
MeSH terms: Cell Differentiation, Cell Movement, Female, Genitalia, Germ Cells, Humans, Pregnancy, Sex Differentiation, Disorders of Sex Development

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