Cited by 344Endometriosis Research and TreatmentUterine Myomas and TreatmentsGynecological conditions and treatments

Pathogenesis of uterine adenomyosis, invagination or metaplasia?

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García-Solares, Javier, Donnez, Jacques, Donnez, Olivier, Dolmans, Marie-Madeleine·2018·Fertility and Sterility

Abstract

Adenomyosis is a commonly diagnosed estrogen-dependent gynecological disorder that causes pelvic pain, abnormal uterine bleeding, and infertility. Despite its prevalence and severity of symptoms, its pathogenesis and etiology have not yet been elucidated. The aim of this manuscript is to review the different hypotheses on the origin of adenomyotic lesions and the mechanisms involved in the evolution and progression of the disease. Two main theories have been proposed to explain the origin of adenomyosis. The most common suggests involvement of tissue injury and the repair mechanism and claims that adenomyosis results from invagination of the endometrial basalis into the myometrium. An alternative theory maintains that adenomyotic lesions result from metaplasia of displaced embryonic pluripotent Müllerian remnants or differentiation of adult stem cells. Previous investigations performed in human adenomyotic lesions and corroborated by studies in mice supported the involvement of the epithelial-mesenchymal transition process in the early stages of progression and spread of adenomyosis. However, studies conducted in a recently developed baboon model indicate that collective cell migration may be implicated in the later events of invasion. This suggests that the invasiveness of this complex uterine disorder is not driven by a single mechanism of migration but by a time-dependent combination of two processes.

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Crossref · 10.1016/j.fertnstert.2017.12.030

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  • Adenomyosis is a common gynecologic disorder with poorly understood pathogenesis and pathophysiology.

    “Adenomyosis, defined as the presence of endometrial glands and stroma infiltrated deep and haphazardly into the myometrium [1], is a common gynecologic disorder with poorly understood pathogenesis and pathophysiology [2,3,4].”

    From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [4]

  • Currently there are two major prevailing and competing theories of adenomyosis pathogenesis: invagination and metaplasia.

    “Currently, there are essentially two major prevailing and competing theories: invagination and metaplasia [4].”

    From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [4]

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Authors
García-Solares, J., Donnez, J., Donnez, O., & Dolmans, M.-M.
Affiliations
  • UCLouvain (BE)
  • Cliniques Universitaires Saint-Luc (BE)
Corresponding author
Dolmans, Marie-Madeleine
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2018-03
Volume
109
Issue
3
Pages
371-379
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2794246050
Cited by
339
References
100
Citations by year
2026: 39 · 2025: 46 · 2024: 33 · 2023: 48 · 2022: 57 · 2021: 53 · 2020: 41 · 2019: 17 · 2018: 4
FWCI
4.55
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
adenomyosis, pathogenesis, metaplasia, Müllerian remnants, stem cell differentiation, epithelial-mesenchymal transition, collective cell migration, baboon model, myometrium, estrogen-dependent disease
MeSH terms
Animals, Cell Movement, Estradiol, Female, Humans, Metaplasia, Mullerian Ducts, Time Factors, Uterine Diseases, Uterus, Signal Transduction, Disease Progression, Pluripotent Stem Cells, Epigenesis, Genetic, Embryonic Stem Cells, Adult Stem Cells, Epithelial-Mesenchymal Transition, Adenomyosis

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