Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

Cited by (918)

Items 101–200 of 918

1. Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA
   Weiwen Kong, Yuning Wei, Zirong Dong, Wenjuan Liu, Jiaxin Zhao, Yan Huang, Jinlong Yang, Wei Wu, Haisheng He, Jianping Qi · 2024 · Journal of Nanobiotechnology
2. Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery
   Grayson Tilstra, Julien Couture‐Senécal, Yan Ming Anson Lau, Alanna M. Manning, D. Wong, Wanda W. Janaeska, Titobioluwa A. Wuraola, Janice Pang, Omar F. Khan · 2023 · Journal of the American Chemical Society
3. Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection
   Roy Pattipeiluhu, Ye Zeng, Marco M. R. M. Hendrix, Ilja Karina Voets, Alexander Kros, Thomas Harry Sharp · 2024 · Nature Communications
4. mRNA-Based Vaccines
   Frank Kowalzik, Daniel Schreiner, Christian Jensen, Daniel Teschner, Stephan Gehring, Fred Zepp · 2021 · Vaccines
5. Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients
   Arne Matteo Jörgensen, Richard Wibel, Andreas Bernkop‐Schnürch · 2023 · Small
6. mRNA vaccine trafficking and resulting protein expression after intramuscular administration
   Kimberly J. Hassett, Ivana Liric Rajlic, Kapil Bahl, Rebecca A. White, Kristen B. Cowens, Eric Jacquinet, Kristine E. Burke · 2023 · Molecular Therapy — Nucleic Acids
7. SARS-CoV-2 (Covid-19) vaccines structure, mechanisms and effectiveness: A review
   Hadis Fathizadeh, Saman Afshar, Mahmood Reza Masoudi, Pourya Gholizadeh, Mohammad Asgharzadeh, Khudaverdi Ganbarov, Şükran Köse, Mehdi Yousefi, Hossein Samadi Kafil · 2021 · International Journal of Biological Macromolecules
8. Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid‐Nanoparticle Components for Therapeutic and Vaccine Applications
   Kieu Lam, Ada Leung, Alan Martin, Mark Wood, Petra Schreiner, Lorne Palmer, Owen M. Daly, Wenchen Zhao, Kevin McClintock, James A. Heyes · 2023 · Advanced Materials
9. Nasal vaccination against SARS-CoV-2: Synergistic or alternative to intramuscular vaccines?
   Mattia Tiboni, Luca Casettari, Lisbeth Illum · 2021 · International Journal of Pharmaceutics
10. Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach
    Han Han Ly, Simon Daniel, Shekinah K. V. Soriano, Zoltán Kis, Anna K. Blakney · 2022 · Molecular Pharmaceutics
11. mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond
    Mariona Estapé Sentí, Lucía García del Valle, Raymond Michel Schiffelers · 2024 · Advanced Drug Delivery Reviews
12. Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2
    Javier Tadeo Granados-Riveron, Guillermo Aquino‐Jarquín · 2021 · Biomedicine & Pharmacotherapy
13. Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2
    Samantha Mackin, Pritesh Desai, Bradley M. Whitener, Courtney E. Karl, Meizi Liu, Ralph Steven Baric, Darin K. Edwards, Taras M. Chicz, Ryan P. McNamara, Galit Alter et al. · 2023 · Nature Microbiology
14. Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety
    Vlatkovic, Irena · 2021 · Biomedicines
15. Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues
    Nisha Chander, Genc Basha, Miffy H. Y. Cheng, Dominik Witzigmann, Pieter R. Cullis · 2023 · Molecular Therapy — Methods & Clinical Development
16. Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach
    Elahe Haghighi, Samira Sadat Abolmaali, Ali Dehshahri, Seyed Ali Mousavi Shaegh, Negar Azarpira, Ali Mohammad Tamaddon · 2024 · Journal of Nanobiotechnology
17. Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics
    Hidefumi Mukai, Koki Ogawa, Naoya Kato, Shigeru Kawakami · 2022 · Drug Metabolism and Pharmacokinetics
18. Rapid development and deployment of high‐volume vaccines for pandemic response
    Kis, Zoltán, Kontoravdi, Cleo, Dey, Antu K., Shattock, Robin, Shah, Nilay · 2020 · Journal of Advanced Manufacturing and Processing
19. Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice
    Baoling Ying, Suzanne M. Scheaffer, Bradley M. Whitener, Chieh-Yu Liang, Oleksandr Dmytrenko, Samantha Mackin, Kai Wu, Diana Wing Lee, Laura E. Avena, Zhenlu Chong et al. · 2022 · Cell
20. Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids
    Johannes Bader, Finn Brigger, Jean‐Christophe Leroux · 2024 · Advanced Drug Delivery Reviews
21. Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives
    Zimei Wu, Tonglei Li · 2021 · Pharmaceutical Research
22. Poly(carboxybetaine) lipids enhance mRNA therapeutics efficacy and reduce their immunogenicity
    Sijin Luozhong, Pingchuan Liu, Ruoxin Li, Zhefan Yuan, Erica L. Debley, Yu Chen, Yuping Hu, Zeyu Cao, Meng Cui, Kay McIlhenny et al. · 2025 · Nature Materials
23. Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors
    Shubaash Anthiya, Süleyman Can Öztürk, Hamdullah Yanık, Ece Tavukçuoğlu, Adem Şahin, Dhrubajyoti Datta, Klaus Charissé, David Moreira, María Isabel Loza, Alfonso Calvo et al. · 2023 · Journal of Controlled Release
24. Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations
    Rafał Hołubowicz, Samuel W. Du, Jiin H. Felgner, Roman Šmidák, Elliot H. Choi, Grażyna Palczewska, Carolline Rodrigues Menezes, Zhiqian Dong, Fangyuan Gao, Omar Medani et al. · 2024 · Nature Biomedical Engineering
25. Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice
    2021
26. Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles
    Uri Elia, Srinivas Ramishetti, Ronit Rosenfeld, Niels Dammes, Erez Bar‐Haim, Gonna Somu Naidu, Efi Makdasi, Yfat Yahalom-Ronen, Hadas Tamir, Nir Paran et al. · 2021 · ACS Nano
27. Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
    Gabriela Baldeon Vaca, Michelle Meyer, Ana Cadete, Chiaowen Joyce Hsiao, Anne S. Golding, Albert B. Jeon, Eric Jacquinet, Emily Azcue, Chenxia Monica Guan, Xavier Sanchez-Felix et al. · 2023 · Science Advances
28. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery
    Jilian R. Melamed, Khalid A. Hajj, Namit Chaudhary, Daria Strelkova, Mariah Lynn Arral, Norbert Pardi, Mohamad‐Gabriel Alameh, Jason B. Miller, Lukas Farbiak, Daniel J. Siegwart et al. · 2021 · Journal of Controlled Release
29. The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency
    Giulia Anderluzzi, Gustavo Lou, Stuart Woods, S. Schmidt, Simona Gallorini, Michela Brazzoli, Russell Johnson, Craig W. Roberts, Derek T. O’Hagan, Barbara C. Baudner et al. · 2021 · Journal of Controlled Release
30. Analysis of PEG-lipid anchor length on lipid nanoparticle pharmacokinetics and activity in a mouse model of traumatic brain injury
    Lauren E. Waggoner, Katelyn F. Miyasaki, Ester J. Kwon · 2023 · Biomaterials Science
31. Chemistry and Art of Developing Lipid Nanoparticles for Biologics Delivery: Focus on Development and Scale-Up
    Rijo John, Jasmin monpara, Shankar Swaminathan, Rahul S. Kalhapure · 2024 · Pharmaceutics
32. Designing lipid nanoparticles using a transformer-based neural network
    Alvin Chan, Ameya R. Kirtane, Qing Rui Qu, Xisha Huang, Jonathan Woo, Deepak A. Subramanian, Rajib Dey, Rika Semalty, Joshua D. Bernstock, Taksim Ahmed et al. · 2025 · Nature Nanotechnology
33. Messenger RNA-Based Vaccines Against Infectious Diseases
    Alameh, Mohamad-Gabriel, Weissman, Drew, Pardi, Norbert · 2020 · Current Topics in Microbiology and Immunology
34. Advances in RNA vaccines for preventive indications: A case study of a vaccine against rabies
    Armbruster, Nicole, Jasny, Edith, Petsch, Benjamin · 2019 · Vaccines
35. Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants
    Guang Han Ong, Benedict Shi Xiang Lian, Takumi Kawasaki, Taro Kawai · 2021 · Frontiers in Cellular and Infection Microbiology
36. Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates
    Kizzmekia S. Corbett, Matthew Gagné, Danielle A. Wagner, Sarah O’ Connell, Sandeep Narpala, Dillon R. Flebbe, Shayne F. Andrew, Rachel L. Davis, Barbara J. Flynn, Timothy S. Johnston et al. · 2021 · Science
37. Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo
    Tian Zhang, Han Yin, Yu Li, Haiyin Yang, Kun Ge, Jinchao Zhang, Qing Yuan, Xuyan Dai, Abid Naeem, Yuhua Weng et al. · 2024 · iScience
38. Lipid nanoparticle (LNP) mediated mRNA delivery in cardiovascular diseases: Advances in genome editing and CAR T cell therapy
    Setareh Soroudi, Mahmoud Reza Jaafari, Leila Arabi · 2024 · Journal of Controlled Release
39. Safety and Immunogenicity of an mRNA-Based Human Metapneumovirus and Parainfluenza Virus Type 3 Combined Vaccine in Healthy Adults
    Allison August, Christine A. Shaw, Heather Ruth Lee, Conor Knightly, Shiva Kalidindia, Laurence Chu, Brandon J. Essink, William Seger, Tal Z. Zaks, Igor V. Smolenov et al. · 2022 · Open Forum Infectious Diseases
40. Treatment of Hemophilia A Using Factor VIII Messenger RNA Lipid Nanoparticles
    Chen, Chun-Yu, Tran, Dominic M., Cavedon, Alex, Cai, Xiaohe, Rajendran, Raj, Lyle, Meghan J., Martini, Paolo G.V., Miao, Carol H. · 2020 · Molecular Therapy Nucleic Acids
41. A Biopharmaceutical Perspective on Higher-Order Structure and Thermal Stability of mRNA Vaccines
    Marek A. Kloczewiak, Jessica M. Banks, Lin Jin, Mark L. Brader · 2022 · Molecular Pharmaceutics
42. Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein
    Nigel M. Davies, Daniel Hovdal, Nicholas J. Edmunds, Peter Nordberg, Anders Dahlén, Aleksandra P. Dabkowska, Marianna Yanez Arteta, Aurel Rădulescu, Tomas Kjellman, Andreas Höijer et al. · 2021 · Molecular Therapy — Nucleic Acids
43. Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination
    Ai‐Ming Yu, Mei‐Juan Tu · 2021 · Pharmacology & Therapeutics
44. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy
    Oscar Escalona-Rayo, Ye Zeng, Renzo A. Knol, Thomas J. F. Kock, Dennis Aschmann, Bram Slütter, Alexander Kros · 2023 · Biomedicine & Pharmacotherapy
45. A comprehensive comparison of DNA and RNA vaccines
    Chunxi Wang, Fan Yuan · 2024 · Advanced Drug Delivery Reviews
46. Beyond the Endosomal Bottleneck: Understanding the Efficiency of mRNA/LNP Delivery
    Haiyin Liu, Moore Z. Chen, Thomas J. Payne, Christopher J. H. Porter, Colin William Pouton, Angus P. R. Johnston · 2024 · Advanced Functional Materials
47. A flexible, thermostable nanostructured lipid carrier platform for RNA vaccine delivery
    Alana Gerhardt, Emily A. Voigt, Michelle C. Archer, Sierra Reed, Elise Larson, Neal Van Hoeven, Ryan M. Kramer, Christopher B. Fox, Corey Casper · 2022 · Molecular Therapy — Methods & Clinical Development
48. Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains
    Ying, Baoling, Whitener, Bradley, VanBlargan, Laura A., Hassan, Ahmed O., Shrihari, Swathi, Liang, Chieh-Yu, Karl, Courtney E., Mackin, Samantha, Chen, Rita E., Kafai, Natasha M. et al. · 2022 · Science Translational Medicine
49. Current State of the First COVID-19 Vaccines
    Birgit M. Prüβ · 2021 · Vaccines
50. An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties in mice and non-human primates
    Manon Ripoll, Marie‐Clotilde Bernard, Céline Vaure, Emilie Bazin, Sylvie Commandeur, Vladimir Perkov, Katia Lemdani, Marie‐Claire Nicolaï, Patrick Bonifassi, Antoine Kichler et al. · 2022 · Biomaterials
51. Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications
    Carolina Lopes, Joana S. Cristóvão, Vânia Silvério, Paulo Roque Lino, Pedro Fonte · 2022 · Expert Opinion on Drug Delivery
52. Advanced technologies for the development of infectious disease vaccines
    Akash Gupta, Arnab Rudra, Kaelan Reed, Róbert Langer, Daniel G. Anderson · 2024 · Nature Reviews Drug Discovery
53. A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice
    Claude Roth, Tineke Cantaert, Chloé Colas, Matthieu Prot, Isabelle Casadémont, Laurine Levillayer, Jessie Thalmensi, Pierre Langlade‐Demoyen, Christiane Gerke, Kapil Bahl et al. · 2019 · Frontiers in Immunology
54. Engineering Gene Therapy: Advances and Barriers
    Alireza Shahryari, Ingo Burtscher, Zahra Nazari, Heiko Lickert · 2021 · Advanced Therapeutics
55. Rational design and combinatorial chemistry of ionizable lipids for RNA delivery
    Yue Xu, Alex Golubovic, Shufen Xu, Anni Pan, Bowen Li · 2023 · Journal of Materials Chemistry B
56. The mixing method used to formulate lipid nanoparticles affects mRNA delivery efficacy and organ tropism
    Daria M. Strelkova Petersen, Namit Chaudhary, Mariah Lynn Arral, Ryan M. Weiss, Kathryn A. Whitehead · 2023 · European Journal of Pharmaceutics and Biopharmaceutics
57. In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors
    Xuexiang Han, Junchao Xu, Ying Xu, Mohamad‐Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan D. El-Mayta, Rohan Palanki, Claude C. Warzecha, Gan Zhao et al. · 2024 · Nature Communications
58. Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles
    Douglas W. Brown, Ping Wee, Prakash Bhandari, Amirali B. Bukhari, Liliya Grin, Héctor Vega, Maryam Hejazi, Deborah L. Sosnowski, Jailal Ablack, Eileen K. Clancy et al. · 2024 · Cell
59. Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System
    Laura Catenacci, Rachele Rossi, Francesca Sechi, Daniela Buonocore, Milena Sorrenti, Sara Perteghella, Marco Peviani, Maria Cristina Bonferoni · 2024 · Pharmaceutics
60. Rational design of anti‐inflammatory lipid nanoparticles for mRNA delivery
    Hanwen Zhang, Xuexiang Han, Mohamad‐Gabriel Alameh, Sarah J. Shepherd, Marshall Scott Padilla, Lulu Xue, Kamila Butowska, Drew Weissman, Michael J. Mitchell · 2022 · Journal of Biomedical Materials Research Part A
61. Design and lyophilization of lipid nanoparticles for mRNA vaccine and its robust immune response in mice and nonhuman primates
    Yuta Suzuki, Takayuki Miyazaki, Hiroki Muto, Kenji Kubara, Yohei Mukai, Ryuji Watari, Shinya Sato, Keita Kondo, Shin‐ichi Tsukumo, Koji Yasutomo et al. · 2022 · Molecular Therapy — Nucleic Acids
62. The role of helper lipids in optimising nanoparticle formulations of self-amplifying RNA
    Beatriz Dias Barbieri, David J. Peeler, Karnyart Samnuan, Suzanne Day, Kai Hu, Hadijatou Sallah, John S. Tregoning, Paul F. McKay, Robin J. Shattock · 2024 · Journal of Controlled Release
63. Lipid Nanoparticle Delivery Systems to Enable mRNA-Based Therapeutics
    Sean C. Semple, Robert D. Leone, Christopher Barbosa, Ying K. Tam, Paulo J.C. Lin · 2022 · Pharmaceutics
64. Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines
    Iman Mohammed Alfagih, Basmah Nasser Aldosari, Bushra T. AlQuadeib, Alanood S. Almurshedi, Mariyam M. Alfagih · 2020 · Pharmaceutics
65. Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo
    Lili Cui, Morag Rose Hunter, Silvia Sonzini, Sara G. T. Pereira, Steven M. Romanelli, Kai Liu, Weimin Li, Lihuan Liang, Bin Yang, Najet Mahmoudi et al. · 2021 · Small
66. mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy
    Kosuke Sasaki, Yusuke Sato, Kento Okuda, Kazuki Iwakawa, Hideyoshi Harashima · 2022 · Pharmaceutics
67. Process Robustness in Lipid Nanoparticle Production: A Comparison of Microfluidic and Turbulent Jet Mixing
    Matthew N. O’Brien, Antonio P. Costa, Yareli Maciel Cebrero, Johnson Joseph, Apoorva Sarode, Nanzhi Zang, Lee Joon Kim, Kate Hofmann, Shirley Wang, Alexandre Goyon et al. · 2023 · Molecular Pharmaceutics
68. Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing
    Apoorva Sarode, Yuchen Fan, Amy E. Byrnes, Michal Hammel, Greg L. Hura, Yige Fu, Ponien Kou, Chloe Hu, Flora I. Hinz, Jasmine Roberts et al. · 2022 · Nanoscale Advances
69. Spray dried lipid nanoparticle formulations enable intratracheal delivery of mRNA
    Kristina Pagh Friis, Sandra Gracin, Steven Oag, Alexandra Leijon, Elin Sand, Botilda Lindberg, Elisa Lázaro‐Ibáñez, Johnny Lindqvist, Kathryn A. Whitehead, Annette Bak · 2023 · Journal of Controlled Release
70. Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery
    Magdalena M. Żak, Lior Zangi · 2021 · Pharmaceutics
71. Unlocking the Therapeutic Applicability of LNP-mRNA: Chemistry, Formulation, and Clinical Strategies
    Xiaonan Huang, Yishan Ma, Guanghui Ma, Yufei Xia · 2024 · Research
72. Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics
    Pieter Vervaeke, Sven Even Borgos, Niek N. Sanders, Francis Combes · 2022 · Advanced Drug Delivery Reviews
73. mRNA vaccines: Past, present, future
    Mia Karam, Georges Daoud · 2022 · Asian Journal of Pharmaceutical Sciences
74. Acidification-Induced Structure Evolution of Lipid Nanoparticles Correlates with Their In Vitro Gene Transfections
    Zongyi Li, Jessica Carter, Luis Santos, Carl I. Webster, Christopher F. van der Walle, Peixun Li, Sarah E. Rogers, Jian Ren Lu · 2023 · ACS Nano
75. Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution
    Xuexiang Han, Mohamad‐Gabriel Alameh, Ying Xu, Rohan Palanki, Rakan D. El-Mayta, Garima Dwivedi, Kelsey L. Swingle, Junchao Xu, Ningqiang Gong, Lulu Xue et al. · 2024 · Nature Biomedical Engineering
76. Use of Microfluidics to Prepare Lipid-Based Nanocarriers
    Alicia Vogelaar, Samantha Marcotte, Jiaqi Cheng, Benazir Oluoch, Jennica L. Zaro · 2023 · Pharmaceutics
77. Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates
    Matthew Gagné, Barbara J. Flynn, Shayne F. Andrew, Josue Marquez, Dillon R. Flebbe, Anna Mychalowych, Evan Lamb, Meredith E. Davis-Gardner, Matthew R. Burnett, Leonid Serebryannyy et al. · 2024 · Nature Immunology
78. In vivo fate and intracellular trafficking of vaccine delivery systems
    Jaiwoo Lee, Dongyoon Kim, Junho Byun, Yina Wu, Jin-Won Park, Yu‐Kyoung Oh · 2022 · Advanced Drug Delivery Reviews
79. Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
    Marine Z. C. Hatit, Curtis N. Dobrowolski, Melissa P. Lokugamage, David Loughrey, Huanzhen Ni, Chiara Zurla, Alejandro J. Da Silva Sanchez, Afsane Radmand, Sebastian G. Huayamares, Ryan Zenhausern et al. · 2023 · Nature Chemistry
80. Ionizable Lipid Nanoparticles for mRNA Delivery
    Xuefeng Tang, Ying Zhang, Xiaojun Han · 2023 · Advanced NanoBiomed Research
81. Chimeric Fusion (F) and Attachment (G) Glycoprotein Antigen Delivery by mRNA as a Candidate Nipah Vaccine
    Rebecca J. Loomis, Anthony T. DiPiazza, Samantha Falcone, Tracy J. Ruckwardt, Kaitlyn M. Morabito, Olubukola M. Abiona, Lauren A. Chang, Ria T. Caringal, Vladimir Presnyak, Elisabeth Narayanan et al. · 2021 · Frontiers in Immunology
82. A Multidimensional Approach to Modulating Ionizable Lipids for High‐Performing and Organ‐Selective mRNA Delivery
    Zepeng He, Zhicheng Le, Yi Shi, Lixin Liu, Zhijia Liu, Yongming Chen · 2023 · Angewandte Chemie International Edition
83. Trends in Drug Delivery Systems for Natural Bioactive Molecules to Treat Health Disorders: The Importance of Nano-Liposomes
    Raiane Vieira Cardoso, Patrícia Ribeiro Pereira, Cyntia Silva Freitas, Vânia Margaret Flosi Paschoalin · 2022 · Pharmaceutics
84. Exploring the impact of commonly used ionizable and pegylated lipids on mRNA-LNPs: A combined in vitro and preclinical perspective
    Burcu Binici, Zahra Rattray, Assaf Zinger, Yvonne Perrie · 2024 · Journal of Controlled Release
85. The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery
    Akari Hashiba, Manaya Toyooka, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima · 2020 · Journal of Controlled Release
86. mRNA-carrying lipid nanoparticles that induce lysosomal rupture activate NLRP3 inflammasome and reduce mRNA transfection efficiency
    James Forster, Dipika Nandi, Ashish A. Kulkarni · 2022 · Biomaterials Science
87. Machine learning empowered formulation design, optimization and characterization of nanoparticulate drug delivery systems: Current applications, challenges, and future perspectives
    Chunyan Shen, Mengyan Zhang, Meiting Lu, Errong Chang, Ziting Gao, Weikang Ban, Qiang Liu, Zhong Zuo, Cuiping Jiang · 2025 · Acta Pharmaceutica Sinica B
88. pH‐Responsive β‐Glucans‐Complexed mRNA in LNPs as an Oral Vaccine for Enhancing Cancer Immunotherapy
    Po-Kai Luo, Hui‐Min Ho, Min‐Chun Chiang, Li‐An Chu, Ya‐Han Chuang, Pingchiang C. Lyu, I‐Chen Hu, Wan-An Chang, Sheng‐Yao Peng, Jayachandran Jayakumar et al. · 2024 · Advanced Materials
89. mRNA-Based Therapeutics in Cancer Treatment
    Han Sun, Yu Zhang, Ge Wang, Wen Yang, Yingjie Xu · 2023 · Pharmaceutics
90. The impact of nucleoside base modification in mRNA vaccine is influenced by the chemistry of its lipid nanoparticle delivery system
    Marie‐Clotilde Bernard, Emilie Bazin, Nadine Petiot, Katia Lemdani, Sylvie Commandeur, Cécile Verdelet, Sylvie Margot, Vladimir Perkov, Manon Ripoll, Marie Garinot et al. · 2023 · Molecular Therapy — Nucleic Acids
91. Enabling mRNA Therapeutics: Current Landscape and Challenges in Manufacturing
    Maryam Youssef, Cynthia Hitti, Julia Puppin Chaves Fulber, Amine Kamen · 2023 · Biomolecules
92. CRISPR–Cas9 delivery strategies for the modulation of immune and non-immune cells
    Shahad K. Alsaiari, Behnaz Eshaghi, Bujie Du, Maria Kanelli, Gang Li, Xunhui Wu, Linzixuan Zhang, Mehr Chaddah, Alicia Lau, Xin Yang et al. · 2024 · Nature Reviews Materials
93. Impact of ionizable lipid type on the pharmacokinetics and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection
    Yuxiang Ren, Lihuan Lin, Mohammad Abdallah, Xueting Zhu, Haiyin Liu, Stewart A. Fabb, Thomas J. Payne, Colin William Pouton, Angus P. R. Johnston, Natalie L. Trevaskis · 2025 · Journal of Controlled Release
94. pH-Dependent Phase Behavior and Stability of Cationic Lipid–mRNA Nanoparticles
    Nicholas R. Larson, Gang Hu, Yangjie Wei, Anthony D. Tuesca, Marcus Laird Forrest, Charles Russell Middaugh · 2021 · Journal of Pharmaceutical Sciences
95. Engineered multi-domain lipid nanoparticles for targeted delivery
    Zhaoyu Liu, Jingxun Chen, Mingkun Xu, Sherwin Ho, Yuanyuan Wei, Ho‐Pui Ho, Ken‐Tye Yong · 2025 · Chemical Society Reviews
96. Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications
    Máté Vadovics, Wenchen Zhao, Emily F. Daley, Kieu Lam, Owen M. Daly, Khalid Rashid, Hailey R. Lee, Petra Schreiner, Kendall A. Lundgreen, Brian T. Gaudette et al. · 2025 · Nature Nanotechnology
97. Brain gene therapy with Trojan horse lipid nanoparticles
    William M. Pardridge · 2023 · Trends in Molecular Medicine
98. Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates
    Maureen Buckley, Mariluz Araínga, Laura Maiorino, Ivan Susin Pires, Byungji Kim, Katarzyna Kaczmarek Michaels, Jonathan Dye, Kashif Qureshi, Yiming J. Zhang, Howard H. Mak et al. · 2025 · Molecular Therapy
99. Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components
    Fan Wu, Nei Li, Yi Xiao, Rohan Palanki, Hannah M. Yamagata, Michael J. Mitchell, Xuexiang Han · 2025 · Small Methods
100. Application of lipid-based nanoparticles in cancer immunotherapy
     Zhongkun Zhang, Siyu Yao, Yingwen Hu, Xiaobin B. Zhao, Robert J. Lee · 2022 · Frontiers in Immunology