Messenger RNA-Based Vaccines Against Infectious Diseases
Abstract
In vitro-transcribed, messenger RNA-based infectious disease vaccines have the potential to successfully address many of the weaknesses of traditional vaccine platforms, such as the lack of potency and/or durability of vaccine protection, time-consuming, and expensive manufacturing, and, in some cases, safety issues. This optimism is fueled by a great deal of impressive recent data demonstrating that mRNA vaccines have many of the attributes that are necessary for a viable new vaccine class for human use. This review briefly describes mRNA vaccine types, discusses the most relevant and recent publications on infectious disease mRNA vaccines, and highlights the hurdles that need to be overcome to bring this promising novel vaccine modality to the clinic.
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Upscaling of cell-free vaccine production is relatively straightforward, providing a cutting-edge tool for rapid response in epidemics and pandemics.
“Furthermore, the upscaling of cell-free vaccine production is relatively straightforward, thereby providing a cutting-edge tool for rapid response in epidemics and pandemics.4, 5, 6, 7”
From COVID-19 mRNA vaccines: Platforms and current developments (2022) · cites this paper as [4]
The success of mRNA vaccines in the COVID-19 vaccine race emphasized the promising potential of this technology in a wide variety of future applications, including other infectious diseases, cancer therapy, and protein replacement therapies.
“The success of mRNA vaccines in the COVID-19 vaccine race emphasized the promising potential of this technology in a wide variety of future applications,176,177 including other infectious diseases,4 cancer therapy,178,179 and protein replacement therapies,180,181”
From COVID-19 mRNA vaccines: Platforms and current developments (2022) · cites this paper as [4]
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Alameh, M.-G., Tombácz, I., Bettini, E., Lederer, K., Ndeupen, S., Sittplangkoon, C., Wilmore, J. R., Gaudette, B. T., Soliman, O. Y., Pine, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.001 · Cited by 775 · see citing works
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- Authors
- Alameh, M.-G., Weissman, D., & Pardi, N.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Weissman, Drew
- Venue
- Current Topics in Microbiology and Immunology
- Publisher
- Springer International Publishing
- Published
- 2020
- Volume
- 440
- Pages
- 111-145
- ISSN
- 0070-217X (ISSN-L)
- 2196-9965
- OpenAlex
- W3016350657
- Cited by
- 96
- References
- 39
- Citations by year
- 2026: 3 · 2025: 18 · 2024: 18 · 2023: 11 · 2022: 18 · 2021: 20 · 2020: 8
- FWCI
- 21.32
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current topics in microbiology and immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- mRNA vaccines, infectious disease vaccines, in vitro transcription, vaccine durability, vaccine potency, vaccine production, vaccine safety, clinical translation, vaccine adjuvants
- MeSH terms
- Communicable Diseases, Humans, RNA, Messenger, Vaccines, Synthetic
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