The Association between Vision Impairment and Incidence of Dementia and Cognitive Impairment
Abstract
Topic The magnitude and direction of the association between vision impairment and incident dementia and cognitive impairment in prospective cohort studies was estimated by systematic review and meta-analysis. The global burden of dementia associated with vision impairment then was estimated. Clinical relevance Because a predominant proportion of vision impairment is preventable or treatable, investigating its association with dementia may help to identify an important modifiable factor for the prevention of dementia. Methods A literature search was conducted using PubMed, Embase, Web of Science, and Google Scholar on September 15, 2020. Relative risks (RRs) were pooled using random-effects models and stratified analyses for subgroups representing different study characteristics. Publication bias was evaluated with funnel plots and the Egger test. The global burden of dementia associated with vision impairment was estimated based on the Global Burden of Disease Study data on the prevalence of dementia and vision impairment. Results In the meta-analysis of 14 prospective cohort studies with 6 204 827 participants and 171 888 dementia patients, the pooled RR associated with vision impairment was 1.47 (95% confidence interval [CI], 1.36-1.60). In the meta-analysis of 12 prospective cohort studies with 45 313 participants and 13 350 patients with cognitive impairment, the pooled RR was 1.35 (95% CI, 1.28-1.41). Stratified analyses showed that the associations of vision impairment…
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Vision impairment was associated with a pooled RR for dementia of 1.47 (1.36-1.60) in a meta-analysis of 14 prospective cohort studies including 6,204,827 older adults who were cognitively intact at baseline.
“Vision impairment was associated with a pooled RR for dementia of 1.47 (1.36 -1.60 see figure 8).”
From Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission (2024) · cites this paper as [251]
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1 retracted
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430 · see citing works
RetractedMild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works
GRADE guidelines: 3. Rating the quality of evidence
Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., & Norris, S. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.015 · Cited by 8,285 · see citing works
GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)
Guyatt, G. H., Oxman, A. D., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Montori, V., Akl, E. A., Djulbegovic, B., & Falck-Ytter, Y. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.017 · Cited by 2,798 · see citing works
GRADE guidelines 6. Rating the quality of evidence—imprecision
Guyatt, G. H., Oxman, A. D., Kunz, R., Brozek, J., Alonso-Coello, P., Rind, D., Devereaux, P. J., Montori, V. M., Freyschuss, B., Vist, G., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.012 · Cited by 2,693 · see citing works
Nichols, E., Szoeke, C. E. I., Vollset, S. E., Abbasi, N., Abd-Allah, F., Abdela, J., Aichour, M. T. E., Akinyemi, R. O., Alahdab, F., Asgedom, S. W., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30403-4 · Cited by 2,412 · see citing works
Zeng, X., Zhang, Y., Kwong, J. S. W., Zhang, C., Li, S., Sun, F., Niu, Y., & Du, L. (2015) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12141 · Cited by 2,082 · see citing works
Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.016 · Cited by 1,660 · see citing works
GRADE guidelines: 9. Rating up the quality of evidence
Guyatt, G. H., Oxman, A. D., Sultan, S., Glasziou, P., Akl, E. A., Alonso-Coello, P., Atkins, D., Kunz, R., Brozek, J., Montori, V., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.06.004 · Cited by 1,336 · see citing works
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Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Livingston, G., Huntley, J., Liu, K. Y., Costafreda, S. G., Selbæk, G., Alladi, S., Ames, D., Banerjee, S., Burns, A., Brayne, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01296-0 · Cited by 3,860 · see citing works
Telemedicine and Dementia Care: A Systematic Review of Barriers and Facilitators
Yi, J. S., Pittman, C. A., Price, C. L., Nieman, C. L., & Oh, E. S. (2021) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2021.03.015 · Cited by 143 · see citing works
Visual impairment, eye diseases, and dementia risk: a systematic review and meta-analysis
Kuźma, E., Littlejohns, T. J., Khawaja, A. P., Llewellyn, D. J., Ukoumunne, O. C., & Thiem, U. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-210250 · Cited by 83 · see citing works
Ehrlich, J. R., Goldstein, J., Swenor, B. K., Whitson, H., Langa, K. M., & Veliz, P. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.0723 · Cited by 69 · see citing works
Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank
Shang, X., Zhu, Z., Huang, Y., Zhang, X., Wang, W., Shi, D., Jiang, Y., Yang, X., & He, M. (2023) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2021-319508 · Cited by 56 · see citing works
Self-citation
- Authors
- Shang, X., Zhu, Z., Wang, W., Ha, J., & He, M.
- Affiliations
- Guangdong Academy of Medical Sciences (CN)
- Sun Yat-sen University (CN)
- Centre for Eye Research Australia (AU)
- Corresponding author
- He, Mingguang
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 128
- Issue
- 8
- Pages
- 1135-1149
- ISSN
- 0161-6420 (ISSN-L)
- OpenAlex
- W3119938821
- Cited by
- 174
- References
- 9
- Citations by year
- 2026: 38 · 2025: 40 · 2024: 45 · 2023: 20 · 2022: 19 · 2021: 12
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Ophthalmology and Visual Impairment Studies
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- visual impairment, dementia, cognitive impairment, dementia risk factors, modifiable risk factors, dementia prevention, economic inequality, older adults, vision screening
- MeSH terms
- Dementia, Humans, Prospective Studies, Risk Factors, Vision Disorders, Incidence, Persons with Visual Disabilities, Visually Impaired Persons, Cognitive Dysfunction
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