Mucositis: The impact, biology and therapeutic opportunities of oral mucositis

Sonis, Stephen T.

doi:10.1016/j.oraloncology.2009.08.006

Cited by 525Oral health in cancer treatmentChemotherapy-related skin toxicityOral Health Pathology and Treatment

Mucositis: The impact, biology and therapeutic opportunities of oral mucositis

Sonis, Stephen T.·2009·Oral Oncology

DOI 10.1016/j.oraloncology.2009.08.006

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Abstract

The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinicians, no effective treatment existed. Fortunately, the situation is changing; ongoing research is leading to a comprehensive understanding of the biology of mucositis, which has resulted in the development of novel interventions. While the FDA's approval of palifermin in 2004 was limited to only a small percentage of the at-risk population, the fact that the first registered anti-OM agent derived its efficacy from its pleotropic activities was conceptually demonstrative of the therapeutic potential of drugs that selectively interfere with mucositis' pathogenesis. A number of eclectic molecules, all designed to interfere with pathways that lead to injury are in pre-clinical and clinical development.

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ROS can mediate the deleterious effects of radiation and contribute to DNA damage and activation of senescence pathways in cells.
“reactive oxygen species (ROS) can mediate the deleterious effects of radiation and contribute to DNA damage and the activation of senescence pathways in cells (Diehn et al., 2009; Kuilman et al., 2010; Sonis, 2009; Spitz et al., 2004).”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009
mTOR inhibition might ameliorate mucositis by preventing the release of a pro-senescent and pro-inflammatory secretome from normal and irradiated cells.
“suggesting that mTOR inhibition might also ameliorative mucositis by preventing the release of a pro-senescent and pro-inflammatory secretome from normal and irradiated cells (Sonis, 2009)”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009
Generation of ROS is an important mediator of cellular alterations caused by radiation exposure, including mucositis.
“The generation of ROS is also an important mediator of the cellular alterations caused by radiation exposure (Diehn et al., 2009; Sonis, 2009; Spitz et al., 2004), including mucositis (Citrin et al., 2010; Cotrim et al., 2007; Cotrim et al., 2005).”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009

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OUP accepted manuscript
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Authors: Sonis, S. T.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Sonis, Stephen T.
ORCID: Sonis, Stephen T.
Venue: Oral Oncology
Publisher: Elsevier BV
Published: 2009-12
Volume: 45
Issue: 12
Pages: 1015-1020
ISSN: 1368-8375 (ISSN-L)
DOI: 10.1016/j.oraloncology.2009.08.006
OpenAlex: W2145063848
Cited by: 525
References: 42
Citations by year: 2026: 22 · 2025: 37 · 2024: 39 · 2023: 34 · 2022: 35 · 2021: 52 · 2020: 35 · 2019: 30 · 2018: 24 · 2017: 31 · 2016: 28 · 2015: 33 · 2014: 35 · 2013: 30 · 2012: 24
FWCI: 2.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Oral Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Oral health in cancer treatment
Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
Keywords: oral mucositis, radiation-induced mucositis, chemotherapy-induced mucositis, palifermin, mucositis treatment, cancer treatment side effects, preclinical drug development
MeSH terms: Animals, Drug Therapy, Female, Cricetinae, Head and Neck Neoplasms, Humans, Male, Mouth Mucosa, Radiotherapy, Risk Factors, Stomatitis, Drug-Related Side Effects and Adverse Reactions

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Mucositis: The impact, biology and therapeutic opportunities of oral mucositis

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