The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Mucositis: The impact, biology and therapeutic opportunities of oral mucositis
Abstract
The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinicians, no effective treatment existed. Fortunately, the situation is changing; ongoing research is leading to a comprehensive understanding of the biology of mucositis, which has resulted in the development of novel interventions. While the FDA's approval of palifermin in 2004 was limited to only a small percentage of the at-risk population, the fact that the first registered anti-OM agent derived its efficacy from its pleotropic activities was conceptually demonstrative of the therapeutic potential of drugs that selectively interfere with mucositis' pathogenesis. A number of eclectic molecules, all designed to interfere with pathways that lead to injury are in pre-clinical and clinical development.
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“reactive oxygen species (ROS) can mediate the deleterious effects of radiation and contribute to DNA damage and the activation of senescence pathways in cells (Diehn et al., 2009; Kuilman et al., 2010; Sonis, 2009; Spitz et al., 2004).”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009
In the citing paper
“suggesting that mTOR inhibition might also ameliorative mucositis by preventing the release of a pro-senescent and pro-inflammatory secretome from normal and irradiated cells (Sonis, 2009)”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009
In the citing paper
“The generation of ROS is also an important mediator of the cellular alterations caused by radiation exposure (Diehn et al., 2009; Sonis, 2009; Spitz et al., 2004), including mucositis (Citrin et al., 2010; Cotrim et al., 2007; Cotrim et al., 2005).”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as Sonis, 2009
Citations
Cites
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Palifermin for Oral Mucositis after Intensive Therapy for Hematologic Cancers
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Oral Mucositis and the Clinical and Economic Outcomes of Hematopoietic Stem-Cell Transplantation
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Metadata
- Authors
- Sonis, S. T.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Sonis, Stephen T.
- ORCID
- Sonis, Stephen T.
- Venue
- Oral Oncology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 45
- Issue
- 12
- Pages
- 1015-1020
- ISSN
- 1368-8375 (ISSN-L)
- OpenAlex
- W2145063848
- Cited by
- 525
- References
- 42
- Citations by year
- 2026: 22 · 2025: 37 · 2024: 39 · 2023: 34 · 2022: 35 · 2021: 52 · 2020: 35 · 2019: 30 · 2018: 24 · 2017: 31 · 2016: 28 · 2015: 33 · 2014: 35 · 2013: 30 · 2012: 24
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › General Dentistry › Oral health in cancer treatment
- Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
- Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
- Keywords
- oral mucositis, radiation-induced mucositis, chemotherapy-induced mucositis, palifermin, mucositis treatment, cancer treatment side effects, preclinical drug development
- MeSH terms
- Animals, Drug Therapy, Female, Cricetinae, Head and Neck Neoplasms, Humans, Male, Mouth Mucosa, Radiotherapy, Risk Factors, Stomatitis, Drug-Related Side Effects and Adverse Reactions
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