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Determinants of behavioral and psychological symptoms of dementia: A scoping review of the evidence
Open accessAbstract
Background Behavioral and psychological symptoms of dementia (BPSD) are prevalent in people with neurodegenerative diseases.Purpose In this scoping review the Kales, Gitlin and Lykestos framework is used to answer the question: What high quality evidence exists for the patient, caregiver and environmental determinants of five specific BPSD: aggression, agitation, apathy, depression and psychosis?Method An a priori review protocol was developed; 692 of 6013 articles retrieved in the search were deemed eligible for review. Gough's Weight of Evidence Framework and the Cochrane Collaboration's tool for assessing risk of bias were used. The findings from 56 high quality/low bias articles are summarized.Discussion Each symptom had its own set of determinants, but many were common across several symptoms: neurodegeneration, type of dementia, severity of cognitive impairments, and declining functional abilities, and to a lesser extent, caregiver burden and communication.Conclusion Research and policy implications are relevant to the National Plan to Address Alzheimer's Disease.
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“Common and persistent non-cognitive symptoms in dementia, NPS are broadly understood to have personal, caregiving, and environmental determinants.8”
From Discharge Communication of Dementia-Related Neuropsychiatric Symptoms and Care Management Strategies during Hospital to Skilled Nursing Facility Transitions (2021) · cites this paper as [8]
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Metadata
- Authors
- Kolanowski, A., Boltz, M., Galik, E., Gitlin, L. N., Kales, H. C., Resnick, B., Van Haitsma, K. S., Knehans, A., Sutterlin, J. E., Sefcik, J. S., Liu, W., Petrovsky, D. V., Massimo, L., Gilmore-Bykovskyi, A., MacAndrew, M., Brewster, G., Nalls, V., Jao, Y.-L., Duffort, N., & Scerpella, D.
- Affiliations
- Pennsylvania State University (US)
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- University of Michigan (US)
- University of Pennsylvania (US)
- University of Iowa (US)
- Queensland University of Technology (AU)
- Corresponding author
- Kolanowski, Ann
- ORCID
- Venue
- Nursing Outlook
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 65
- Issue
- 5
- Pages
- 515-529
- ISSN
- 0029-6554 (ISSN-L)
- PMC
- PMC6579119
- OpenAlex
- W2625547843
- Cited by
- 165
- References
- 100
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 13 · 2023: 22 · 2022: 27 · 2021: 30 · 2020: 24 · 2019: 14 · 2018: 12 · 2017: 2
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nursing Outlook (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (K99AG056054)
- National Institute of Nursing Research (F32NR014777)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Geriatric Care and Nursing Homes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Keywords
- behavioral and psychological symptoms of dementia, dementia, aggression, agitation, apathy, depression, psychosis, risk factors, neurodegeneration, cognitive impairment severity, functional decline, caregiver burden, communication, Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Aggression, Alzheimer Disease, Dementia, Depression, Female, Humans, Male, Middle Aged, Psychomotor Agitation, Psychotic Disorders, Apathy
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