Cited by 41Neurological diseases and metabolismIron Metabolism and DisordersParkinson's Disease Mechanisms and Treatments

Long-term improvement under deferiprone in a case of neurodegeneration with brain iron accumulation

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Kwiatkowski, A., Ryckewaert, G., Jissendi Tchofo, P., Moreau, C., Vuillaume, I., Chinnery, P.F., Destée, A., Defebvre, L. +1 more·2012·Parkinsonism & Related Disorders

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Crossref · 10.1016/j.parkreldis.2011.06.024

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5 of 5 references verified0 citation errors · 0 not checkable

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  • In a patient with moderate parkinsonism, deferiprone 30 mg/kg per day given orally for 32 months improved many symptoms after 6 months and improved Unified Parkinson's Disease Rating Scale score after 1 year, with rapid decrease in iron accumulation in bilateral dentate nuclei, milder and later reduction in substantia nigra, but no significant changes in red nuclei.

    “After 6 months many of the symptoms had improved, and after 1 year an improvement was recorded in the Unified Parkinson’s Disease Rating Scale score. T2*-weighted MRI showed a rapid decrease in iron accumulation in the bilateral dentate nuclei, with a milder and later reduction in the substantia nigra, but no significant changes in the red nuclei.213”

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Authors
Kwiatkowski, A., Ryckewaert, G., Jissendi Tchofo, P., Moreau, C., Vuillaume, I., Chinnery, P. F., Destée, A., Defebvre, L., & Devos, D.
Venue
Parkinsonism & Related Disorders
Publisher
Elsevier BV
Published
2012-01
Volume
18
Issue
1
Pages
110-112
ISSN
1353-8020 (ISSN-L)
OpenAlex
W2061326167
Cited by
41
References
5
Citations by year
2025: 2 · 2024: 2 · 2022: 5 · 2021: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 5
FWCI
2.83
Type
journal article
Language
en
Open access
Locations
  • Parkinsonism & Related Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
  • Wellcome Trust (096919)
  • National Institute for Health and Care Research (NF-SI-0509-10011)
  • Indian Council of Agricultural Research
Topics
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
neurodegeneration with brain iron accumulation, deferiprone
MeSH terms
Deferiprone, Female, Humans, Iron Chelating Agents, Middle Aged, Pyridones, Time Factors, Treatment Outcome, Iron Overload, Neurodegenerative Diseases

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