The DOI matches its Crossref record; 70 of the 72 references it cites were found in a registry or an index.
Gastroparesis and Parkinson’s disease: A systematic review
Abstract
Some of the gastrointestinal (GI) symptoms commonly experienced by patients with Parkinson's disease (PD) have been attributed to gastroparesis; however, the precise prevalence and relevance of gastric emptying delay in PD is unclear. The definition of gastroparesis varies; currently the most widely accepted definition (from the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium) is the presence of appropriate symptoms (including nausea, retching, vomiting, stomach fullness, and inability to finish a meal) for ≥ 12 weeks, together with delayed gastric emptying on scintigraphy and the absence of any obstructive lesions on upper GI endoscopy. In PD patients, gastroparesis has the potential to affect nutrition and quality of life, as well as the absorption of PD medications, including L-dopa. This reduced absorption of L-dopa has implications for the control of the PD motor symptoms for which it is administered. We performed a systematic review of the literature on gastroparesis in PD with the aim of developing an evidence-based approach to its management. Based on this review, we conclude that while gastric emptying has been reported to be frequently delayed in PD, the existing data do not permit definitive conclusions concerning its true prevalence, relationship to the underlying disease process, relevance to PD management, or the optimal therapy of related GI symptoms. Further study of these important issues is, therefo…
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“Gastric motor dysfunction can impair levodopa pharmacokinetics and contribute to motor fluctuations (Pfeiffer et al., 2020); systematic reviews support the association between PD and gastroparesis (Heetun et al., 2012).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Heetun et al., 2012
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1 retracted
Janssen, P., Oudenhove, L. V., Bisschops, R., & Tack, J. F. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.078 · Cited by 19
RetractedStaging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Gastrointestinal dysfunction in Parkinson's disease
Pfeiffer, R. F. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00307-7 · Cited by 933
Where Does Parkinson Disease Pathology Begin in the Brain?
Del Tredici, K., Rüb, U., de Vos, R. A. I., Bohl, J. R. E., & Braak, H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.5.413 · Cited by 773
Soykan, I., Sivri, B., Sarosiek, I., Kiernan, B., & Mccallum, R. W. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1026665728213 · Cited by 575
Gastric electrical stimulation for medically refractory gastroparesis
Abell, T. L., McCallum, R. W., Hocking, M. P., Koch, K. L., Abrahamsson, H., Leblanc, I., Lindberg, G., Konturek, J. W., Nowak, T. V., Quigley, E. M. M., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00878-3 · Cited by 563
Self-citationParkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses
Wakabayashi, K., Takahashi, H., Takeda, S., Ohama, E., & Ikuta, F. (1988) · Acta Neuropathologica · doi:10.1007/bf00687767 · Cited by 528
Gastric pacing improves emptying and symptoms in patients with gastroparesis
McCallum, R. W., Chen, J. D. Z., Lin, Z., Schirmer, B. D., Williams, R. D., & Ross, R. A. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70528-1 · Cited by 415
Revicki, D. A., Rentz, A. M., Dubois, D., Kahrilas, P. J., Stanghellini, V., Talley, N. J., & Tack, J. F. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01612.x · Cited by 382
Gastrointestinal symptoms in Parkinson's disease
Edwards, L. L., Pfeiffer, R. F., Quigley, E. M. M., Hofman, R., & Balluff, M. (1991) · Movement Disorders · doi:10.1002/mds.870060211 · Cited by 373
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Gastrointestinal Dysfunction in Parkinson’s Disease
Fasano, A., Visanji, N. P., Liu, L. W. C., Lang, A. E., & Pfeiffer, R. F. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00007-1 · Cited by 1,016
Li, W., Wu, X., Hu, X., Wang, T., Liang, S., Duan, Y., Jin, F., & Qin, B. (2017) · Science China Life Sciences · doi:10.1007/s11427-016-9001-4 · Cited by 406
Ma, K., Xiong, N., Shen, Y., Han, C., Liu, L., Zhang, G., Wang, L., Guo, S., Guo, X., Xia, Y. F., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00001 · Cited by 394
Chen, Z., Li, G., & Liu, J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104700 · Cited by 364
Vinarov, Z., Abdallah, M., Agúndez, J. A. G., Allegaert, K., Basit, A. W., Braeckmans, M., Ceulemans, J., Corsetti, M., Griffin, B. T., Grimm, M. F., et al. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105812 · Cited by 396
Metadata
- Authors
- Heetun, Z. S., & Quigley, E. M. M.
- Affiliations
- University College Cork (IE)
- Corresponding author
- Quigley, Eamonn M.M.
- ORCID
- Quigley, Eamonn M.M.
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 18
- Issue
- 5
- Pages
- 433-440
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2077886817
- Cited by
- 182
- References
- 72
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 7 · 2023: 16 · 2022: 15 · 2021: 20 · 2020: 12 · 2019: 12 · 2018: 9 · 2017: 13 · 2016: 15 · 2015: 13 · 2014: 11 · 2013: 7 · 2012: 4
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- UCB Pharma
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- gastroparesis, Parkinson's disease
- MeSH terms
- Antiparkinson Agents, Humans, Levodopa, Parkinson Disease, Quality of Life, Databases, Bibliographic, Gastroparesis
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