Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses

Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

Braak, H., R�b, U., Gai, W. P., & Del Tredici, K. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0808-2 · Cited by 1,683 · see citing works

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354 · see citing works

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

Unger, M. M., Spiegel, J., Dillmann, K.-U., Grundmann, D., Philippeit, H., Bürmann, J., Faßbender, K., Schwiertz, A., & Schäfer, K.-H. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.08.019 · Cited by 1,159 · see citing works

Gastrointestinal Dysfunction in Parkinson’s Disease

Fasano, A., Visanji, N. P., Liu, L. W. C., Lang, A. E., & Pfeiffer, R. F. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00007-1 · Cited by 1,016 · see citing works

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

Forsyth, C. B., Shannon, K. M., Kordower, J. H., Voigt, R. M., Shaikh, M., Jaglin, J. A., Estes, J. D., Dodiya, H. B., & Keshavarzian, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028032 · Cited by 974 · see citing works

Guidelines on the irritable bowel syndrome: mechanisms and practical management

Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818 · see citing works

Spreading of pathology in neurodegenerative diseases: a focus on human studies

Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

Polymeropoulos, M. H., Higgins, J. J., Golbe, L. I., Johnson, W. G., Ide, S. E., Di Iorio, G., Sanges, G., Stenroos, E. S., Pho, L. T., Schaffer, A. A., et al. (1996) · Science · doi:10.1126/science.274.5290.1197 · Cited by 788 · see citing works

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Mahul-Mellier, A.-L., Burtscher, J., Maharjan, N., Weerens, L., Croisier, M., Kuttler, F., Leleu, M., Knott, G. W., & Lashuel, H. A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913904117 · Cited by 710 · see citing works

Protein transmission in neurodegenerative disease

Peng, C., Trojanowski, J. Q., & Lee, V. M.-Y. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0333-7 · Cited by 625 · see citing works

The bowel and beyond: The enteric nervous system in neurological disorders

Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629 · see citing works

Colonic inflammation in Parkinson's disease

Devos, D., Lebouvier, T., Lardeux, B., Biraud, M., Rouaud, T., Pouclet, H., Coron, E., Bruley des Varannes, S., Naveilhan, P., Nguyen, J.-M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.09.007 · Cited by 627 · see citing works

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

Houser, M. C., & Tansey, M. G. (2017) · npj Parkinson's Disease · doi:10.1038/s41531-016-0002-0 · Cited by 588 · see citing works

Brain-Gut-Microbiota Axis in Parkinson’s Disease

Mulak, A. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10609 · Cited by 583 · see citing works

The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic

Tan, A. H., Lim, S. Y., & Lang, A. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00681-2 · Cited by 392 · see citing works

Exploring Braak’s hypothesis of Parkinson’s disease

Rietdijk, C. D., Perez-Pardo, P., Garssen, J., van Wezel, R. J. A., & Kraneveld, A. D. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00037 · Cited by 395 · see citing works

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

Dickson, D. W., Fujishiro, H., DelleDonne, A., Menke, J., Ahmed, Z., Klos, K. J., Josephs, K. A., Frigerio, R., Burnett, M., Parisi, J. E., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0345-7 · Cited by 364 · see citing works

Multiple organ involvement by alpha-synuclein pathology in lewy body disorders

Gelpi, E., Navarro‐Otano, J., Tolosa, E., Gaig, C., Compta, Y., Rey, M. J., Martí, M. J., Hernández, I., Valldeoriola, F., Reñé, R., et al. (2014) · Movement Disorders · doi:10.1002/mds.25776 · Cited by 361 · see citing works

Gastrointestinal manifestations in Parkinson's disease: Prevalence and occurrence before motor symptoms

Cersosimo, M. G., Raina, G. B., Pecci, C., Pellene, A., Calandra, C. R., Gutiérrez, C., Micheli, F. E., & Benarroch, E. E. (2013) · Journal of Neurology · doi:10.1007/s00415-012-6801-2 · Cited by 314 · see citing works

Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease

Kelly, L. P., Carvey, P. M., Keshavarzian, A., Shannon, K. M., Shaikh, M., Bakay, R. A. E., & Kordower, J. H. (2014) · Movement Disorders · doi:10.1002/mds.25736 · Cited by 308 · see citing works

Gastrointestinal dysfunction in Parkinson's disease

Pfeiffer, R. F. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.08.003 · Cited by 298 · see citing works

The prion hypothesis in Parkinson's disease: braak to the future

Visanji, N. P., Brooks, P. L., Hazrati, L.-N., & Lang, A. E. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-2 · Cited by 278 · see citing works

In Situ and in Vitro Study of Colocalization and Segregation of α-Synuclein, Ubiquitin, and Lipids in Lewy Bodies

Gai, W. P., Yuan, H. X., Li, X. Q., Power, J. T. H., Blumbergs, P. C., & Jensen, P. H. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7527 · Cited by 272 · see citing works

Role of α-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease

Allen Reish, H. E., & Standaert, D. G. (2015) · Journal of Parkinson’s Disease · doi:10.3233/jpd-140491 · Cited by 244 · see citing works

Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?

Blesa, J., Foffani, G., Dehay, B., Bezard, E., & Obeso, J. A. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00542-9 · Cited by 232 · see citing works

The Microbiome as a Modifier of Neurodegenerative Disease Risk

Fang, P., Kazmi, S. A., Jameson, K. G., & Hsiao, E. Y. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.008 · Cited by 226 · see citing works

Gastrointestinal dysfunction in Parkinson's Disease

Jost, W. H. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.08.020 · Cited by 222 · see citing works

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

Manfredsson, F. P., Luk, K. C., Benskey, M. J., Gezer, A., Garcia, J., Kuhn, N. C., Sandoval, I. M., Patterson, J. R., O'Mara, A., Yonkers, R., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.008 · Cited by 199 · see citing works

Neuronal vulnerability, pathogenesis, and Parkinson's disease

Sulzer, D., & Surmeier, D. J. (2013) · Movement Disorders · doi:10.1002/mds.25187 · Cited by 184 · see citing works

Gastroparesis and Parkinson’s disease: a systematic review

Heetun, Z. S., & Quigley, E. M. M. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.12.004 · Cited by 182 · see citing works

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

Yang, D., Zhao, D., Ali Shah, S. Z., Wu, W., Lai, M., Zhang, X., Li, J., Guan, Z., Zhao, H., Li, W., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01155 · Cited by 162 · see citing works

Clinical Criteria for the Diagnosis of Parkinson’s Disease

Reichmann, H. (2010) · Neurodegenerative Diseases · doi:10.1159/000314478 · Cited by 145 · see citing works

Inflammatory bowel diseases and Parkinson's disease

Brudek, T. (2019) · Journal of Parkinson’s Disease · doi:10.3233/jpd-191729 · Cited by 139 · see citing works

A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease

Pouclet, H., Lebouvier, T., Coron, E., Bruley des Varannes, S., Rouaud, T., Roy, M., Neunlist, M., & Derkinderen, P. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.08.014 · Cited by 138 · see citing works

Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

Brás, I. C., & Outeiro, T. F. (2021) · Cells · doi:10.3390/cells10020375 · Cited by 136 · see citing works

Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments

Poirier, A.-A., Aubé, B., Côté, M., Morin, N., Di Paolo, T., & Soulet, D. (2016) · Parkinson s Disease · doi:10.1155/2016/6762528 · Cited by 130 · see citing works

Reduced striatal tyrosine hydroxylase in incidental Lewy body disease

Beach, T. G., Adler, C. H., Sue, L. I., Peirce, J. B., Bachalakuri, J., Dalsing-Hernandez, J. E., Lue, L. F., Caviness, J. N., Connor, D. J., Sabbagh, M. N., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-007-0313-7 · Cited by 128 · see citing works

Gastrointestinal Dysfunction in Parkinson’s Disease

Pfeiffer, R. F. (2018) · Current Treatment Options in Neurology · doi:10.1007/s11940-018-0539-9 · Cited by 94 · see citing works

Gastrointestinal autonomic dysfunction in patients with Parkinson’s disease

Kim, J.-S., & Sung, H.-Y. (2015) · Journal of Movement Disorders · doi:10.14802/jmd.15008 · Cited by 76 · see citing works

The pathology roadmap in Parkinson disease

Surmeier, D. J., & Sulzer, D. (2013) · Prion · doi:10.4161/pri.23582 · Cited by 74 · see citing works

The gut–brain axis in early Parkinson’s disease: from prodrome to prevention

Oliver, P. J., Civitelli, L., & Hu, M. T. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13138-5 · Cited by 42 · see citing works

Exploring the connection between the gut microbiome and parkinson's disease symptom progression and pathology: implications for supplementary treatment options

Chan, D. G., Ventura, K., Villeneuve, A., Du Bois, P., & Holahan, M. R. (2022) · Journal of Parkinson's Disease · doi:10.3233/jpd-223461 · Cited by 24 · see citing works

Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson’s Disease

Drobny, A., Ngo, P. A., Neurath, M. F., Zunke, F., & López-Posadas, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655123 · Cited by 24 · see citing works