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Cited by 274Parkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disordersGut microbiota and health

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Small intestinal bacterial overgrowth in Parkinson's disease

Tan, Ai Huey, Mahadeva, Sanjiv, Thalha, Abdul Malik, Gibson, Peter R., Kiew, Chiun Khang, Yeat, Chia Ming, Ng, Sheang Wen, Ang, Sheau Phing, Chow, Siew Kian, Tan, Chong Tin, Yong, Hoi Sen, Marras, Connie, Fox, Susan H., Lim, Shen-Yang·2014·Parkinsonism & Related Disorders
DOI 10.1016/j.parkreldis.2014.02.019
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Abstract

Background Recent studies reported a high prevalence of small intestinal bacterial overgrowth (SIBO) in Parkinson's disease (PD), and a possible association with gastrointestinal symptoms and worse motor function. We aimed to study the prevalence and the potential impact of SIBO on gastrointestinal symptoms, motor function, and quality of life in a large cohort of PD patients.Methods 103 Consecutive PD patients were assessed using the lactulose-hydrogen breath test; questionnaires of gastrointestinal symptoms and quality of life (PDQ-39); the Unified PD Rating Scale (UPDRS) including "on"-medication Part III (motor severity) score; and objective and quantitative measures of bradykinesia (Purdue Pegboard and timed test of gait). Patients and evaluating investigators were blind to SIBO status.Results 25.3% of PD patients were SIBO-positive. SIBO-positive patients had a shorter mean duration of PD (5.2 ± 4.1 vs. 8.1 ± 5.5 years, P = 0.007). After adjusting for disease duration, SIBO was significantly associated with lower constipation and tenesmus severity scores, but worse scores across a range of "on"-medication motor assessments (accounting for 4.2-9.0% of the variance in motor scores). There was no association between SIBO and motor fluctuations or PDQ-39 Summary Index scores.Conclusions This is the largest study to date on SIBO in PD. SIBO was detected in one quarter of patients, including patients recently diagnosed with the disease. SIBO was not associated with worse gastrointestinal symptoms, but independently predicted worse motor function. Properly designed treatment trials are needed to confirm a causal link between SIBO and worse motor function in PD.

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Crossref · 10.1016/j.parkreldis.2014.02.019

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Metadata

Authors
Tan, A. H., Mahadeva, S., Thalha, A. M., Gibson, P. R., Kiew, C. K., Yeat, C. M., Ng, S. W., Ang, S. P., Chow, S. K., Tan, C. T., Yong, H. S., Marras, C., Fox, S. H., & Lim, S.-Y.
Affiliations
  • University of Malaya (MY)
  • The Alfred Hospital (AU)
  • University of Toronto (CA)
Corresponding author
Lim, Shen-Yang
ORCID
Venue
Parkinsonism & Related Disorders
Publisher
Elsevier BV
Published
2014-05
Volume
20
Issue
5
Pages
535-540
ISSN
1353-8020 (ISSN-L)
DOI
10.1016/j.parkreldis.2014.02.019
OpenAlex
W1983564695
Cited by
274
References
34
Citations by year
2026: 8 · 2025: 19 · 2024: 21 · 2023: 24 · 2022: 29 · 2021: 39 · 2020: 34 · 2019: 25 · 2018: 28 · 2017: 20 · 2016: 11 · 2015: 15 · 2014: 1
FWCI
10.21
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Parkinsonism & Related Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
Malaysian Ministry of Higher Education
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
small intestinal bacterial overgrowth, Parkinson's disease
MeSH terms
Aged, Bacterial Infections, Female, Humans, Hydrogen, Intestinal Diseases, Lactulose, Male, Middle Aged, Parkinson Disease, Quality of Life, Surveys and Questionnaires, Regression Analysis, Severity of Illness Index, Prevalence

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