Intestinal Permeability and Orocaecal Transit Time in Elderly Patients with Parkinson’s Disease
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The aetiology of weight loss in patients with Parkinson's disease is likely to be multifactorial. We studied 15 patients with Parkinson's disease and 15 age- and sex-matched controls and looked for evidence of malabsorption due to small bowel bacterial overgrowth or alteration of intestinal permeability. There was a marked increase in orocaecal transit time in the patients with Parkinson's disease, although lactulose hydrogen breath testing did not show evidence of small bowel bacterial contamination. Intestinal permeability measured by the differential sugar absorption test was also deranged. There was reduced absorption of mannitol in patients with Parkinson's disease while lactulose absorption was similar in both groups, suggesting decreased non-mediated uptake across the enterocyte brush border membrane in patients with Parkinson's disease.
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Abnormal lactulose/mannitol ratio and sucrose concentration values found in subjects with Parkinson's disease have been associated with tight junction alterations.
“abnormal lactulose/mannitol ratio and sucrose concentration values found in subjects with PD have been associated with tight junction alterations [138,139]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [139]
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- Authors
- Davies, K. N., King, D., Billington, D., & Barrett, J. A.
- Affiliations
- Clatterbridge Hospital (GB)
- Liverpool John Moores University (GB)
- Corresponding author
- Davies, K N
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-03-01
- Volume
- 72
- Issue
- 845
- Pages
- 164-167
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- PMC
- PMC2398397
- OpenAlex
- W2016253973
- Cited by
- 88
- References
- 34
- Citations by year
- 2026: 3 · 2025: 4 · 2023: 4 · 2022: 5 · 2021: 12 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Postgraduate Medical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- Parkinson's disease, intestinal permeability, weight loss, malabsorption, small intestinal bacterial overgrowth, brush border membrane, elderly patients
- MeSH terms
- Aged, Aged, 80 and over, Breath Tests, Female, Gastrointestinal Transit, Humans, Intestinal Absorption, Intestine, Small, Lactulose, Male, Mannitol, Parkinson Disease, Permeability, Case-Control Studies
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