Non-motor symptoms and the quality of life in multiple system atrophy with different subtypes
Abstract
Background The differences in non-motor symptoms (NMS) and quality of life (QOL) between MSA patients with different subtypes remain unknown, so do the determinants of poor QOL in both subtypes.Methods A total of 172 MSA patients were enrolled in the study. NMS of patients with MSA were assessed using the non-motor symptoms scale (NMSS) and Parkinson's Disease Questionnaire-39 item version (PDQ-39) was used to evaluate the QOL of patients with MSA.Results The most prevalent NMS domain was urinary (91.3%) in both subtypes. The mood/apathy domain was more severe in MSA-P than MSA-C patients (P < 0.05). Drooling, constipation, and pain symptoms were more prevalent and severe in the MSA-P patients compared to the MSA-C patients (P < 0.05). We found that the MSA-C patients had a higher score of mobility than the MSA-P patients (P = 0.002); However, the MSA-P patients had a higher score of bodily discomfort than the MSA-C patients (P = 0.036). There were close correlations between NMS and PDQ-39 in both subtypes. Disease severity, cardiovascular symptoms, sleep/fatigue symptoms and gastrointestinal symptoms were determinants of poor QOL in MSA-P patients. While in MSA-C patients, longer disease duration, disease severity and mood/apathy symptoms were determinants of poor QOL.Conclusion NMS are more severe and prevalent in MSA-P patients, especially for mood/apathy and gastrointestinal symptoms. There is a close relationship between NMS and QOL in both MSA subtypes. Disease severity, longer disease duration and severe NMS are determinants of poor QOL in MSA.
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Patients with PSP showed a higher rate of cognitive, behavioral, and urinary dysfunctions, while those with MSA had higher prevalence of urinary dysfunction, sleep/fatigue symptoms, and mood disorders than patients with PD.
“Patients with PSP showed a higher rate of cognitive, behavioral, and urinary dysfunctions, while those with MSA had higher prevalence of urinary dysfunction, sleep/fatigue symptoms, and mood disorders than patients with PD [18, 19].”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [18]
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- Authors
- Zhang, L., Cao, B., Ou, R., Wei, Q.-Q., Zhao, B., Yang, J., Wu, Y., & Shang, H.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Shang, HuiFang
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 35
- Pages
- 63-68
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2561442395
- Cited by
- 59
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 10 · 2022: 11 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 2
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Fund of China (81571247, 81371394)
- Sichuan University (2016SCU11017)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- multiple system atrophy, MSA-P
- MeSH terms
- Aged, Cross-Sectional Studies, Female, Gastrointestinal Diseases, Humans, Male, Middle Aged, Quality of Life, Multiple System Atrophy, Mood Disorders
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