Cited by 349Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNeurological diseases and metabolism

Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy

Trojanowski, J. Q., Revesz, T., the Neuropathology Working Group on MSA·2007·Neuropathology and Applied Neurobiology

Abstract

This report summarizes the recommendations of the multiple system atrophy (MSA) Working Group on Diagnostic Neuropathology Criteria for MSA that was part of an international MSA Workshop held on 26 and 27 April 2007 in Boston, MA. The workshop was supported by a grant from the National Institute of Neurological Disorders and Stroke that was intended to convene a group of international experts to revise and update criteria for the clinical and neuropathological diagnosis of MSA. The MSA Workshop recognized the glial cytoplasmic inclusions (GCIs) composed of filamentous alpha‐synuclein as a defining morphological feature of MSA, and it recommends that widespread GCIs should be a criterion for the definite neuropathological diagnosis of MSA. The deliberations and recommendations of the Working Group on Diagnostic Neuropathology Criteria for MSA are summarized in this report.

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Crossref · 10.1111/j.1365-2990.2007.00907.x

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Authors
Trojanowski, J. Q., Revesz, T., & the Neuropathology Working Group on MSA
Affiliations
  • University of Pennsylvania (US)
  • Mayo Clinic (US)
Corresponding author
Trojanowski, J. Q.
Venue
Neuropathology and Applied Neurobiology
Publisher
Wiley
Published
2007-11-06
Volume
33
Issue
6
Pages
615-620
ISSN
  • 0305-1846 (ISSN-L)
  • 1365-2990
OpenAlex
W1969040413
Cited by
349
References
27
Citations by year
2026: 11 · 2025: 23 · 2024: 25 · 2023: 25 · 2022: 36 · 2021: 31 · 2020: 24 · 2019: 17 · 2018: 18 · 2017: 16 · 2016: 13 · 2015: 21 · 2014: 16 · 2013: 15 · 2012: 15
FWCI
6.23
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropathology and Applied Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Parkinson's UK (G-4062)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
multiple system atrophy, neuropathological diagnosis, diagnostic criteria, glial cytoplasmic inclusions, alpha-synuclein, postmortem diagnosis, synucleinopathies
MeSH terms
Autopsy, Brain, Humans, Multiple System Atrophy

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