Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy
Abstract
This report summarizes the recommendations of the multiple system atrophy (MSA) Working Group on Diagnostic Neuropathology Criteria for MSA that was part of an international MSA Workshop held on 26 and 27 April 2007 in Boston, MA. The workshop was supported by a grant from the National Institute of Neurological Disorders and Stroke that was intended to convene a group of international experts to revise and update criteria for the clinical and neuropathological diagnosis of MSA. The MSA Workshop recognized the glial cytoplasmic inclusions (GCIs) composed of filamentous alpha‐synuclein as a defining morphological feature of MSA, and it recommends that widespread GCIs should be a criterion for the definite neuropathological diagnosis of MSA. The deliberations and recommendations of the Working Group on Diagnostic Neuropathology Criteria for MSA are summarized in this report.
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A significant constituent of GCI is insoluble α-syn.
“A significant constituent of GCI is insoluble α-syn.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [289]
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- Authors
- Trojanowski, J. Q., Revesz, T., & the Neuropathology Working Group on MSA
- Affiliations
- University of Pennsylvania (US)
- Mayo Clinic (US)
- Corresponding author
- Trojanowski, J. Q.
- ORCID
- Trojanowski, J. Q.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2007-11-06
- Volume
- 33
- Issue
- 6
- Pages
- 615-620
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1969040413
- Cited by
- 349
- References
- 27
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 25 · 2023: 25 · 2022: 36 · 2021: 31 · 2020: 24 · 2019: 17 · 2018: 18 · 2017: 16 · 2016: 13 · 2015: 21 · 2014: 16 · 2013: 15 · 2012: 15
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Parkinson's UK (G-4062)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- multiple system atrophy, neuropathological diagnosis, diagnostic criteria, glial cytoplasmic inclusions, alpha-synuclein, postmortem diagnosis, synucleinopathies
- MeSH terms
- Autopsy, Brain, Humans, Multiple System Atrophy
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