Helicobacter pylori infection is associated with an increased risk of Parkinson's disease: A population-based retrospective cohort study
Abstract
Background Several studies have evaluated the association of Parkinson's disease with Helicobacter pylori (HP) infection, although no cohort studies have evaluated this association among the general population. Objective This study aimed to investigate the risk of Parkinson's disease after HP infection in the general Taiwanese population. Methods This study of Taiwanese health insurance data (2000-2012) evaluated 9105 cases of HP infection and 9105 controls matched with propensity scoring. Univariate and multivariate Cox proportional hazards regression models were used to assess the risk of subsequent Parkinson's disease. Results We observed 64 cases of Parkinson's disease in the HP infection group (1.7/1000 person-years), and 25 cases in the control group (0.7/1000 person-years). Overall, there was a significantly higher risk of Parkinson's disease in the HP infection group (adjusted hazard ratio [aHR]: 2.29, 95% confidence interval [CI]: 1.44-3.66). HP infection was significantly associated with an increased risk of Parkinson's disease among individuals who were ≥60 years old (aHR: 2.53, 95% CI: 1.47-4.35), but not among those <60 years old (aHR: 1.86, 95% CI: 0.69-4.98). Furthermore, HP infection was associated with an increased risk of Parkinson's disease among both men (aHR: 2.14, 95% CI: 1.15-3.96) and women (aHR: 2.84, 95% CI: 1.37-5.89). Nonetheless, eradication therapy was not significantly associated with the risk of Parkinson's disease (aHR: 1.07, 95% CI: 0.63-1.82). Conclusion Although HP infection was associated with an increased risk of Parkinson's disease, eradication therapy did not ameliorate this association. Further research is needed to explore the underlying biological mechanisms.
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H. pylori infection is associated with PD risk.
“In a similar vein, H. pylori infection, associated with PD risk [110, 111], is thought to contribute to motor dysfunction at late stages by reducing levodopa bioavailability, and at early stages through induction of local and systemic inflammation.”
From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [111]
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Small intestinal bacterial overgrowth in Parkinson's disease
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Zhao, Z., Ning, J., Bao, X.-Q., Shang, M., Ma, J., Li, G., & Zhang, D. (2021) · Microbiome · doi:10.1186/s40168-021-01107-9 · Cited by 616 · see citing works
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The gut–brain axis in early Parkinson’s disease: from prodrome to prevention
Oliver, P. J., Civitelli, L., & Hu, M. T. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13138-5 · Cited by 42 · see citing works
“In a similar vein, H. pylori infection, associated with PD risk [110, 111], is thought to contribute to motor dysfunction at late stages by reducing levodopa bioavailability, and at early stages through induction of local and systemic inflammation.”
Liu, X., Shen, L., Wan, M., Xie, H., & Wang, Z. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02428-1 · Cited by 33 · see citing works
- Authors
- Huang, H.-K., Wang, J.-H., Lei, W.-Y., Chen, C.-L., Chang, C.-Y., & Liou, L.-S.
- Affiliations
- Tzu Chi Foundation (TW)
- Tzu Chi University (TW)
- Tri-Service General Hospital (TW)
- Corresponding author
- Chang, Chih-Ya
- Liou, Li-Syue
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 47
- Pages
- 26-31
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2769248573
- Cited by
- 106
- References
- 2
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 18 · 2023: 11 · 2022: 10 · 2021: 22 · 2020: 15 · 2019: 9 · 2018: 7
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Helicobacter pylori infection, Parkinson's disease
- MeSH terms
- Adult, Aged, Anti-Bacterial Agents, Female, Humans, Male, Middle Aged, Parkinson Disease, Risk Factors, Taiwan, Cohort Studies, Helicobacter pylori, Helicobacter Infections, Outcome Assessment, Health Care, Community Health Planning, Disease Eradication
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