Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma
Abstract
Approximately 360 million people worldwide are chronically infected with hepatitis B virus (HBV) and are at high risk of developing hepatocellular carcinoma (HCC). Chronic HBV infection is the most prevalent cause of this tumour, accounting for 55% of global cases, and 89% of those in endemic regions for HBV infection. Relative risks for developing HCC in the presence of chronic HBV infection may be as high as 49 in case-control studies, and 98 in cohort studies. HCC is the sixth most common cancer in the world today, with approximately 630,000 new cases occurring each year. It ranks third in annual cancer mortality rates. Approximately 80% of HCCs occur in developing countries where HBV infection is endemic, with the highest incidences being in the Asia-Pacific region, and sub-Saharan Africa. In the chronic carriers of the virus who are at greatest risk of developing HCC, the infection is acquired at birth or in the early months or years of life, either perinatally or horizontally, and frequently becomes chronic. The risks are greater in males, and older individuals, and are increased by co-exposure to aflatoxin B(1), the presence of cirrhosis, obesity, or diabetes mellitus, and possibly co-infection with hepatitis C virus. Viral factors that influence the risk of HCC are high viral load, the presence of certain mutations, and genotypes. Although the incidence of chronic HBV infection is beginning to decrease as a result of the universal infant immunization programme, HBV-induced HCC incidence is projected to increase for at least another two decades.
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Perinatally acquired hepatitis B is the leading cause of adult liver cirrhosis in China.
“With 93 million hepatitis B carriers, perinatally acquired hepatitis B is the leading cause of adult liver cirrhosis in China [42,56,57].”
From Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis (2014) · cites this paper as [56]
China has 93 million hepatitis B carriers.
“With 93 million hepatitis B carriers, perinatally acquired hepatitis B is the leading cause of adult liver cirrhosis in China [42,56,57].”
From Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis (2014) · cites this paper as [56]
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- Authors
- Kew, M. C.
- Affiliations
- University of Cape Town (ZA)
- Corresponding author
- Kew, M.C.
- Venue
- Pathologie Biologie
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 58
- Issue
- 4
- Pages
- 273-277
- ISSN
- 0369-8114 (ISSN-L)
- OpenAlex
- W1995958786
- Cited by
- 275
- References
- 63
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 11 · 2021: 16 · 2020: 13 · 2019: 26 · 2018: 12 · 2017: 21 · 2016: 22 · 2015: 28 · 2014: 36 · 2013: 27 · 2012: 25
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pathologie Biologie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Keywords
- chronic hepatitis B, hepatocellular carcinoma, HBV genotypes, HBV mutations, aflatoxin B1, liver cirrhosis, hepatitis C coinfection, cancer incidence and mortality, risk factors, developing countries
- MeSH terms
- Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Male, Risk, Sex Factors, Aflatoxin B1, Hepatitis B Vaccines, Endemic Diseases, Hepatitis B, Chronic
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