Influence of anisotropic conduction properties in the propagation of the cardiac action potential

Valderrábano, Miguel

doi:10.1016/j.pbiomolbio.2007.03.014

Cited by 125Cardiac electrophysiology and arrhythmiasConnexins and lens biologyCardiac Arrhythmias and Treatments

Influence of anisotropic conduction properties in the propagation of the cardiac action potential

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Valderrábano, Miguel·2007·Progress in Biophysics and Molecular Biology

DOI 10.1016/j.pbiomolbio.2007.03.014PMC PMC1995420

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Abstract

Anisotropy, the property of being directionally dependent, is ubiquitous in nature. Propagation of the electrical impulse in cardiac tissue is anisotropic, a property that is determined by molecular, cellular, and histological determinants. The properties and spatial arrangement of connexin molecules, the cell size and geometry, and the fiber orientation and arrangement are examples of structural determinants of anisotropy. Anisotropy is not a static property but is subject to dynamic functional regulation, mediated by modulation of gap junctional conductance. Tissue repolarization is also anisotropic. The relevance of anisotropy extends beyond normal propagation and has important implications in pathological states, as a potential substrate for abnormal rhythms and reentry.

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In healthy tissues, action potentials propagate faster in the direction of cell alignment, with myocytes showing slower conduction velocities in the transverse direction.
“In healthy tissues, action potentials propagate faster in the direction of cell alignment, with myocytes showing slower conduction velocities (CVs) in the transverse direction (33).”
From Recreating the heart's helical structure-function relationship with focused rotary jet spinning (2022) · cites this paper as [33]

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Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes
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Electroconductive Melt Electrowritten Patches Matching the Mechanical Anisotropy of Human Myocardium
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Anisotropic conductive reduced graphene oxide/silk matrices promote post-infarction myocardial function by restoring electrical integrity
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Sympathetic modulation of electrical activation in normal and infarcted myocardium: implications for arrhythmogenesis
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Galectin-3 in Atrial Fibrillation: Mechanisms and Therapeutic Implications
Clémenty, N., Piver, É., Bisson, A., André, C., Bernard, A., Pierre, B., Fauchier, L., & Babuty, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040976 · Cited by 65 · see citing works
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Polarization-Dependent Atomic Force Microscopy–Infrared Spectroscopy (AFM-IR): Infrared Nanopolarimetric Analysis of Structure and Anisotropy of Thin Films and Surfaces
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Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Ripplinger, C. M., Glukhov, A. V., Kay, M. W., Boukens, B. J., Chiamvimonvat, N., Delisle, B. P., Fabritz, L., Hund, T. J., Knollmann, B. C., Li, N., et al. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00439.2022 · Cited by 55 · see citing works
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Dynamic and Programmable Cellular-Scale Granules Enable Tissue-like Materials
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Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome
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Bimodal biophotonic imaging of the structure-function relationship in cardiac tissue
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Regulation of the Microenvironment for Cardiac Tissue Engineering
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Advances in 3D Bioprinted Cardiac Tissue Using Stem Cell-Derived Cardiomyocytes
Bliley, J. M., Stang, M. A., Behre, A., & Feinberg, A. W. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae014 · Cited by 38 · see citing works
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Mapping Data Predictors of a Left Ventricular Outflow Tract Origin of Idiopathic Ventricular Tachycardia With V 3 Transition and Septal Earliest Activation
Herczku, C., Berruezo, A., Andreu, D., Fernández‐Armenta, J., Mont, L., Borràs, R., Arbelo, E., Tolosana, J. M., Trucco, E., Ríos, J., et al. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.969592 · Cited by 30 · see citing works
Patient Specific Simulation of Body Surface ECG using the Finite Element Method
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Biomechanical assessment of remote and postinfarction scar remodeling following myocardial infarction
Rusu, M., Hilse, K., Schuh, A., Märtin, L., Slabu, I., Stoppe, C., & Liehn, E. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-53351-7 · Cited by 30 · see citing works
Ventricular myocardium development and the role of connexins in the human fetal heart
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Stem Cell Therapy of Myocardial Infarction: A Promising Opportunity in Bioengineering
Jiang, B., Yan, L., Shamul, J. G., Hakun, M., & He, X. (2020) · Advanced Therapeutics · doi:10.1002/adtp.201900182 · Cited by 27 · see citing works
Integrated Manufacturing of Suspended and Aligned Nanofibrous Scaffold for Structural Maturation and Synchronous Contraction of HiPSC-Derived Cardiomyocytes
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High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones
Zhu, C., Rajendran, P. S., Hanna, P., Efimov, I. R., Salama, G., Fowlkes, C. C., & Shivkumar, K. (2022) · JCI Insight · doi:10.1172/jci.insight.153913 · Cited by 26 · see citing works
Remuscularizing Failing Hearts with Tissue Engineered Myocardium
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Layer-By-Layer Fabrication of Large and Thick Human Cardiac Muscle Patch Constructs With Superior Electrophysiological Properties
Pretorius, D., Kahn-Krell, A. M., Lou, X., Fast, V. G., Berry, J. L., Kamp, T. J., & Zhang, J. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.670504 · Cited by 21 · see citing works
Duración y dispersión del QRS para predecir arritmias ventriculares en las fases iniciales del infarto agudo de miocardio
Chávez-González, E., Jiménez, A. E. R., & Moreno-Martínez, F. L. (2017) · Medicina Intensiva · doi:10.1016/j.medin.2016.09.008 · Cited by 21 · see citing works
Engineering an in vitro organotypic model for studying cardiac hypertrophy
Jain, A., Hasan, J. S., Desingu, P. A., Sundaresan, N. R., & Chatterjee, K. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.02.036 · Cited by 20 · see citing works
Connexin43, A Promising Target to Reduce Cardiac Arrhythmia Burden in Pulmonary Arterial Hypertension
Sýkora, M., Bačová, B. S., Andelová, K. O., Beňová, T. E., Martišková, A., Kurahara, L. H., Hirano, K., & Tribulová, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063275 · Cited by 20 · see citing works
Biomimetic Model of Contractile Cardiac Tissue with Endothelial Networks Stabilized by Adipose-Derived Stromal/Stem Cells
Morrissette-McAlmon, J. B. F., Ginn, B. P., Somers, S. M., Fukunishi, T., Thanitcul, C., Rindone, A. N., Hibino, N., Tung, L., Mao, H., & Grayson, W. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-65064-3 · Cited by 20 · see citing works
Progress of Conductivity and Conduction Velocity Measured in Human and Animal Hearts
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Sbk2, a Newly Discovered Atrium-Enriched Regulator of Sarcomere Integrity
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Extracellular macrostructure anisotropy improves cardiac tissue-like construct function and phenotypic cellular maturation
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Simulation of Cardiac Arrhythmias Using a 2D Heterogeneous Whole Heart Model
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Characterizing Functional Stem Cell–Cardiomyocyte Interactions
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Examination of the Effects of Conduction Slowing on the Upstroke of Optically Recorded Action Potentials
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Fibrosis and Ventricular Arrhythmogenesis
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Gap junction channels: From protein genes to diseases
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Inadvertent atrial dissociation following catheter ablation: A demonstration of cardiac anisotropy and functional block
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Hypertension Induces Pro-arrhythmic Cardiac Connexome Disorders: Protective Effects of Treatment
Sýkora, M., Andelová, K. O., Bačová, B. S., Beňová, T. E., Martišková, A., Knezl, V., & Tribulová, N. (2023) · Biomolecules · doi:10.3390/biom13020330 · Cited by 11 · see citing works
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Authors: Valderrábano, M.
Affiliations: Houston Methodist (US)
Corresponding author: Valderrábano, Miguel
ORCID: Valderrábano, Miguel
Venue: Progress in Biophysics and Molecular Biology
Publisher: Elsevier BV
Published: 2007-05
Volume: 94
Issue: 1-2
Pages: 144-168
ISSN: 0079-6107 (ISSN-L)
DOI: 10.1016/j.pbiomolbio.2007.03.014
PMC: PMC1995420
OpenAlex: W2015162683
Cited by: 125
References: 110
Citations by year: 2026: 2 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 11 · 2021: 10 · 2020: 17 · 2019: 10 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 3
FWCI: 0.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5004 d)
Locations: Progress in Biophysics and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r21hl085215-02)
National Heart, Lung, and Blood Institute (R21-HL085215)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: cardiac anisotropy, cardiac action potential propagation, gap junction conductance, connexins, fiber orientation, reentry, cardiac arrhythmias, cardiac tissue electrophysiology
MeSH terms: Action Potentials, Animals, Computer Simulation, Electric Conductivity, Heart Conduction System, Humans, Models, Cardiovascular, Cardiomyopathies, Anisotropy, Connexins, Myocytes, Cardiac

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Influence of anisotropic conduction properties in the propagation of the cardiac action potential

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