Letter to the Editor - Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report
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Abnormal plasma levels of angiotensin-II and angiotensin-(1-7) have been reported in COVID-19 patients.
“Accordingly, abnormal plasma levels of Ang-II and angiotensin-(1–7) have been reported in COVID-19 patients.15, 16, 17”
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445 · see citing works
Liu, Y., Yang, Y., Zhang, C., Huang, F., Wang, F., Yuan, J., Wang, Z., Li, J., Li, J., Feng, C., et al. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1643-8 · Cited by 2,037 · see citing works
COVID-19, ACE2, and the cardiovascular consequences
South, A. M., Diz, D. I., & Chappell, M. C. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00217.2020 · Cited by 779 · see citing works
Clinical Characteristics of Covid-19 in China
Chen, A. T. C., Coura-Filho, G. B., & Rehder, M. H. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2005203 · Cited by 475 · see citing works
Sanchis‐Gomar, F., Lavie, C. J., Pérez-Quilis, C., Henry, B. M., & Lippi, G. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.03.026 · Cited by 167 · see citing works
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COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
Rysz, S., Al-Saadi, J., Sjöström, A., Farm, M., Campoccia Jalde, F., Plattén, M., Eriksson, H., Klein, M., Vargas-Paris, R., Nyrén, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22713-z · Cited by 111 · see citing works
Lobo, S. M., Plantefève, G., Nair, G., Joaquim Cavalcante, A., Franzin de Moraes, N., Nunes, E., Barnum, O., Berdun Stadnik, C. M., Lima, M. P., Lins, M., et al. (2024) · eClinicalMedicine · doi:10.1016/j.eclinm.2023.102383 · Cited by 27 · see citing works
- Authors
- Henry, B. M., Benoit, S., Lippi, G., & Benoit, J.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- University of Verona (IT)
- University of Cincinnati (US)
- Corresponding author
- Henry, Brandon Michael
- Venue
- Progress in Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 63
- Issue
- 5
- Pages
- 702-703
- ISSN
- 0033-0620 (ISSN-L)
- PMC
- PMC7348599
- OpenAlex
- W3040816265
- Cited by
- 49
- References
- 5
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 20 · 2020: 5
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Cardiovascular Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Cincinnati College of Medicine
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, angiotensin II, aldosterone, plasma hormone levels, renin-angiotensin system, intensive care unit admission, comorbidities
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aldosterone, Angiotensin II, Humans, Pneumonia, Viral, Renin-Angiotensin System, Coronavirus, Coronavirus Infections, Viral Load, Lung Injury, Pandemics
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